PREPARATION AND CHARACTERIZATION OF CURCUMIN NANOPARTICLES LOADED THERMOSENSITIVE GELATIN - PLURONIC F127 HYDROGEL FOR WOUND HEALING APPLICATION

Trinh T. Nguyen, Q. Tran, L. Nguyen, T. T. Nguyen
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Abstract

Curcumin, a natural phenolic compound, is extracted from turmeric exhibiting several biomedical activities. Unfortunately, less aqueous solubility causesl  drawback in medicinal application. This study introduces a method in order to produce a biomaterial containing high content of curcumin nanoparticles, which can overcome curcumin’s poor dissolution and wound healing. This method uses a thermo-reversible pluronic F127-grafted gelatin (GP) which play the role as surfactant to disperse and protect nanocurcumin from aggregation. The synthetic GP copolymer was identified via 1H NMR. Thermal transition behavior was identified under test tube inversion and differential scanning colorimetry (DSC). The synthesized curcumin size was characterized by Transmission Electron  Microscopy (TEM) and Dynamic Light Scattering (DLS), which indicated that the size of nanocurcumin significantly varied ranging from 7 to 285 nm according to the amount of feeded curcurmin. The nanocurcumin-dispersed GP copolymer solution forms the nanocomposite hydrogel when warmed up to 36.27 °C. Release profile indicated the sustainable release control of nanocurcumin  in the thermogel system. These results showed potential application of the biomaterial in tissue regeneration.
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姜黄素纳米颗粒负载热敏明胶- pluronic f127伤口愈合水凝胶的制备与表征
姜黄素是从姜黄中提取的一种天然酚类化合物,具有多种生物医学活性。不幸的是,较低的水溶性在医药应用中造成了缺点。本研究介绍了一种制备高含量姜黄素纳米颗粒生物材料的方法,该材料可以克服姜黄素溶解性差和伤口愈合的问题。该方法采用热可逆pluronic f127接枝明胶(GP)作为表面活性剂分散和保护纳米姜黄素的聚集。合成的GP共聚物经1H NMR鉴定。用试管反演和差示扫描比色法(DSC)研究了其热转变行为。通过透射电镜(TEM)和动态光散射(DLS)对合成的姜黄素粒径进行了表征,结果表明,随着姜黄素投加量的不同,合成的姜黄素粒径在7 ~ 285 nm之间变化显著。将纳米姜黄素分散GP共聚物溶液加热至36.27℃,形成纳米复合水凝胶。释放曲线表明纳米姜黄素在热凝胶体系中的可持续释放控制。这些结果显示了生物材料在组织再生中的潜在应用。
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