{"title":"Novel unsymmetric diimines: Synthesis and biological evaluation against pathogenic microorganisms","authors":"D. Nartop, H. Öğütcü","doi":"10.26655/jmchemsci.2020.3.3","DOIUrl":null,"url":null,"abstract":"In this research study, three new unsymmetric diimines (3a-3c) were prepared using a two-step process. The synthesized unsymmetric tetradentate diimines were elucidated by FT-IR, 1H-NMR, LC-MS, elemental analysis techniques. The antimicrobial and the antifungal properties of newly synthesized unsymmetrical diimines (3a-3c) and previously reported by one of us unsymmetrical diimines (4a-4c) were evaluated against L. monocytogenes 4b, B. cereus sp., S. typhi H, Br. abortus, S. epidermis sp., M. Luteus sp., E. coli, P. putida sp. Sh. dys. typ. 7 ve C. albicans. 3b, 3c, 4a and 4c are showed the highest antimicrobial activity against B.cereus sp. 3a and 4b are exhibited the highest activity against S.epidermis sp. and Br. abortus, respectively. In addition, all unsymmetrical diimines are showed high antifungal activity against C. albicans.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medicinal and Chemical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26655/jmchemsci.2020.3.3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
In this research study, three new unsymmetric diimines (3a-3c) were prepared using a two-step process. The synthesized unsymmetric tetradentate diimines were elucidated by FT-IR, 1H-NMR, LC-MS, elemental analysis techniques. The antimicrobial and the antifungal properties of newly synthesized unsymmetrical diimines (3a-3c) and previously reported by one of us unsymmetrical diimines (4a-4c) were evaluated against L. monocytogenes 4b, B. cereus sp., S. typhi H, Br. abortus, S. epidermis sp., M. Luteus sp., E. coli, P. putida sp. Sh. dys. typ. 7 ve C. albicans. 3b, 3c, 4a and 4c are showed the highest antimicrobial activity against B.cereus sp. 3a and 4b are exhibited the highest activity against S.epidermis sp. and Br. abortus, respectively. In addition, all unsymmetrical diimines are showed high antifungal activity against C. albicans.
本研究采用两步法合成了三种新的不对称二亚胺(3a-3c)。通过FT-IR、1H-NMR、LC-MS、元素分析等手段对合成的非对称四齿二亚胺进行了表征。对新合成的不对称二亚胺(3a-3c)和已有报道的不对称二亚胺(4a-4c)对单核增生L. L. 4b、蜡样芽孢杆菌、斑疹伤寒S. H、Br。流产杆菌、表皮葡萄球菌、黄体芽孢杆菌、大肠杆菌、恶臭杆菌等。typ。7 .白色念珠菌。其中3b、3c、4a和4c对蜡样芽孢杆菌的抑菌活性最高，3a和4b对表皮芽孢杆菌和Br的抑菌活性最高。分别流产。此外，所有非对称二亚胺对白色念珠菌均表现出较高的抗真菌活性。
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
