Women's most typical complaints in the early postpartum period are pain and exhaustion. Pain can make it difficult for a mother to care for herself and her child. Untreated pain is linked to an increased risk of opiate usage, postpartum depression, and the development of chronic pain. Postpartum pain management includes both nonpharmacologic and pharmacologic therapy. This study focused on the features of the course of labour and the postpartum period in women with uterine fibroids in preterm labour. A retrospective analysis of 50 birth histories of women with uterine fibroids who delivered prematurely was carried out. During gestation, most pregnant women have a threat of spontaneous abortion and premature birth. In childbirth, most pregnant women experienced complications such as weakness of labour, cervical dystocia, fetal hypoxia, which often led to the need for an emergency caesarean surgery. More than half of pregnant women with uterine fibroids in the successive and early postpartum period experience bleeding due to uterine hypotension. The combination of uterine fibroids with preterm labour is a particular problem, as it often leads to complications in childbirth and the early postpartum period. This group of patients requires careful pre-gravid preparation, as well as special attention of the antenatal clinic doctor with personalized gynecological and obstetric tactics.
{"title":"Features of Delivery and Course of Postpartum Period in Women with Uterine Fibroids during Premature Birth","authors":"Ivleva Natalya Aleksandrovna, Tyurina Natalya Aleksandrovna, Kidyaeva Irina Aleksandrovna, Suvanov Bakhtiyar Sabitkhanovich, Volgin Yaroslav Yurievich","doi":"10.26655/jmchemsci.2022.1.4","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.1.4","url":null,"abstract":"Women's most typical complaints in the early postpartum period are pain and exhaustion. Pain can make it difficult for a mother to care for herself and her child. Untreated pain is linked to an increased risk of opiate usage, postpartum depression, and the development of chronic pain. Postpartum pain management includes both nonpharmacologic and pharmacologic therapy. This study focused on the features of the course of labour and the postpartum period in women with uterine fibroids in preterm labour. A retrospective analysis of 50 birth histories of women with uterine fibroids who delivered prematurely was carried out. During gestation, most pregnant women have a threat of spontaneous abortion and premature birth. In childbirth, most pregnant women experienced complications such as weakness of labour, cervical dystocia, fetal hypoxia, which often led to the need for an emergency caesarean surgery. More than half of pregnant women with uterine fibroids in the successive and early postpartum period experience bleeding due to uterine hypotension. The combination of uterine fibroids with preterm labour is a particular problem, as it often leads to complications in childbirth and the early postpartum period. This group of patients requires careful pre-gravid preparation, as well as special attention of the antenatal clinic doctor with personalized gynecological and obstetric tactics.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89442737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.26655/jmchemsci.2022.1.15
O. A. Ghareeb
Gold nanoparticles (GNPs) represent the most important applications of nanotechnology in fields of medicine. The study aimed at clarifying their toxic effect, especially upon biochemical parameters related to liver and kidney functions of lab animals. Twenty-four healthy rats were distributed on 4 groups, each containing 6 rats. Control group included rats without any treatment, while GNPs group of mice were under intoxication with gold nanoparticles at a dosage of 50 μl/day for 7 days. As for the GNPs + BS group, intoxicated rats with GNPs were given oil of black seed at a dosage of 10 ml / kg. Finally, BS group included rats were under treatment of 1 ml/ kg of black seed oil. Serum levels of hepato-renal parameters including alanine amino transferase, aspartate amino transferase, alkaline phosphatase, blood urea, creatinine, and uric acid, were measured to detect impaired liver and kidneys functions. Rats treated with GNPs indicated a substantial (P < 0.05) increase in all these biomarkers levels contrasted to the group of control. Then, co-administration of black seed oil together with GNPs had a significant effect on reducing hepatorenal functions disorders. Thus, from these results, it can be concluded that the black seed oil has shown a defensive effect against the disturbances caused by GNPs in the liver and kidney functions of rats.
{"title":"Hepato-Renal Dysfunctions Induced by Gold Nanoparticles and Preservative Efficacy of Black Seed Oil","authors":"O. A. Ghareeb","doi":"10.26655/jmchemsci.2022.1.15","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.1.15","url":null,"abstract":"Gold nanoparticles (GNPs) represent the most important applications of nanotechnology in fields of medicine. The study aimed at clarifying their toxic effect, especially upon biochemical parameters related to liver and kidney functions of lab animals. Twenty-four healthy rats were distributed on 4 groups, each containing 6 rats. Control group included rats without any treatment, while GNPs group of mice were under intoxication with gold nanoparticles at a dosage of 50 μl/day for 7 days. As for the GNPs + BS group, intoxicated rats with GNPs were given oil of black seed at a dosage of 10 ml / kg. Finally, BS group included rats were under treatment of 1 ml/ kg of black seed oil. Serum levels of hepato-renal parameters including alanine amino transferase, aspartate amino transferase, alkaline phosphatase, blood urea, creatinine, and uric acid, were measured to detect impaired liver and kidneys functions. Rats treated with GNPs indicated a substantial (P < 0.05) increase in all these biomarkers levels contrasted to the group of control. Then, co-administration of black seed oil together with GNPs had a significant effect on reducing hepatorenal functions disorders. Thus, from these results, it can be concluded that the black seed oil has shown a defensive effect against the disturbances caused by GNPs in the liver and kidney functions of rats.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83260043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-16DOI: 10.26655/jmchemsci.2022.2.8
Hamid Mirjalili, Hadis Amani, Afsaneh Ismaili, Maryam Milani Fard, A. Abdolrazaghnejad
This study is a conceptual review. Various protocols have been proposed for non-communicable diseases worldwide. The importance of this large group of diseases has prompted the World Health Organization (WHO) to plan effectively to set targets to reduce mortality from these diseases by one-third by 2030 in the Sustainable Development Plan. In asthma, corticosteroids are still recognized as the most potent anti-asthma drugs, and there is still no drug with the same effect, and biological agents (drugs such as amalizumab) significantly improve the management of severe asthma. Regarding diabetes, the recommendations of the WHO were reviewed, and the first recommendation is that if metformin, which is recommended as the first oral antidiabetic drug in all guidelines, cannot control hyperglycemia, sulfonylurea should be prescribed to patients with type 2 diabetes. Non-communicable diseases in Iran cause 45% of the disease burden in men and 33% of the disease burden in women, of the total causes of the disease burden in both sexes (6-10). Obesity and overweight, arterial hypertension, inadequate physical activity and addiction are 86% of the risk factors for diseases and 11% of all diseases. These risk factors have caused 6.1 million years of adapted life expectancy in Iran.
{"title":"Evaluation of Drug Therapy in Non-Communicable Diseases; a Review Study","authors":"Hamid Mirjalili, Hadis Amani, Afsaneh Ismaili, Maryam Milani Fard, A. Abdolrazaghnejad","doi":"10.26655/jmchemsci.2022.2.8","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.2.8","url":null,"abstract":"This study is a conceptual review. Various protocols have been proposed for non-communicable diseases worldwide. The importance of this large group of diseases has prompted the World Health Organization (WHO) to plan effectively to set targets to reduce mortality from these diseases by one-third by 2030 in the Sustainable Development Plan. In asthma, corticosteroids are still recognized as the most potent anti-asthma drugs, and there is still no drug with the same effect, and biological agents (drugs such as amalizumab) significantly improve the management of severe asthma. Regarding diabetes, the recommendations of the WHO were reviewed, and the first recommendation is that if metformin, which is recommended as the first oral antidiabetic drug in all guidelines, cannot control hyperglycemia, sulfonylurea should be prescribed to patients with type 2 diabetes. Non-communicable diseases in Iran cause 45% of the disease burden in men and 33% of the disease burden in women, of the total causes of the disease burden in both sexes (6-10). Obesity and overweight, arterial hypertension, inadequate physical activity and addiction are 86% of the risk factors for diseases and 11% of all diseases. These risk factors have caused 6.1 million years of adapted life expectancy in Iran.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85217833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-13DOI: 10.26655/jmchemsci.2022.2.6
Morita Sari, Syifa Shafira
Antibiotics are chemicals that kill or stop the growth of microscopic organisms or microbes, such as bacteria, fungi, or protozoa. Therefore, antibiotics can be used to treat diseases caused by germs in the body. The objective of the research was to know the description and pattern of antibiotic prescription at Dr. Moewardi Municipality Hospital Dental Ward, Surakarta. This study was based on the observational description with a cross-sectional study design. The samples taken for observation were 321 patients with medical records from September-December 2018. We applied secondary retrospective data and Defined Daily Doses (DDD)/Anatomical Therapeutic Chemical (ATC) from World Health Organization (WHO) Constanta. The data was then rated for its accuracy by tracing using Algorithm Gyssens. The results showed 71.96% of the patients received treatment and drug prescriptions, of which 36.45% were antibiotics. Amoxicillin was the most widely used antibiotic, followed by Clindamycin and Cefixime. The DDD/ATC ratio was 1.639982. The results from observation and identification with Gyssens category revealed that the categories 0, IIA, IIIB, IIIA, IVB, and V accounted for 75.35%, 2.82%, 8.45%, 7.75%, 4.93%, and 0.7%, respectively, of the consumed antibiotics. Accordingly, there is a rational prescription at Dr. Moewardi Municipality Hospital Dental Ward, Surakarta, but it still needs improvement.
抗生素是一种化学物质，可以杀死或阻止微生物或微生物的生长，如细菌、真菌或原生动物。因此，抗生素可以用来治疗由体内细菌引起的疾病。研究的目的是了解苏拉arta Dr. Moewardi市立医院牙科病房抗生素处方的描述和模式。本研究以横断面研究设计的观察性描述为基础。观察样本为2018年9 - 12月有病历的321例患者。我们采用了来自世界卫生组织(WHO) Constanta的二级回顾性数据和定义日剂量(DDD)/解剖治疗化学(ATC)。然后使用算法Gyssens对数据进行跟踪，以评估其准确性。结果显示，71.96%的患者接受了治疗和药物处方，其中抗生素占36.45%。阿莫西林是使用最广泛的抗生素，其次是克林霉素和头孢克肟。DDD/ATC比值为1.639982。Gyssens分类观察鉴定结果显示，0、IIA、IIIB、IIIA、IVB和V类抗菌药物用量分别占总用量的75.35%、2.82%、8.45%、7.75%、4.93%和0.7%。因此，泗水市Moewardi医生市立医院牙科病房有合理的处方，但仍需改进。
{"title":"A Review of Antibiotic Consumptions at Moewardi Municipality Hospital Dental Ward Surakarta, Indonesia Using Algorithm Gyssens","authors":"Morita Sari, Syifa Shafira","doi":"10.26655/jmchemsci.2022.2.6","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.2.6","url":null,"abstract":"Antibiotics are chemicals that kill or stop the growth of microscopic organisms or microbes, such as bacteria, fungi, or protozoa. Therefore, antibiotics can be used to treat diseases caused by germs in the body. The objective of the research was to know the description and pattern of antibiotic prescription at Dr. Moewardi Municipality Hospital Dental Ward, Surakarta. This study was based on the observational description with a cross-sectional study design. The samples taken for observation were 321 patients with medical records from September-December 2018. We applied secondary retrospective data and Defined Daily Doses (DDD)/Anatomical Therapeutic Chemical (ATC) from World Health Organization (WHO) Constanta. The data was then rated for its accuracy by tracing using Algorithm Gyssens. The results showed 71.96% of the patients received treatment and drug prescriptions, of which 36.45% were antibiotics. Amoxicillin was the most widely used antibiotic, followed by Clindamycin and Cefixime. The DDD/ATC ratio was 1.639982. The results from observation and identification with Gyssens category revealed that the categories 0, IIA, IIIB, IIIA, IVB, and V accounted for 75.35%, 2.82%, 8.45%, 7.75%, 4.93%, and 0.7%, respectively, of the consumed antibiotics. Accordingly, there is a rational prescription at Dr. Moewardi Municipality Hospital Dental Ward, Surakarta, but it still needs improvement.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86050620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-13DOI: 10.26655/jmchemsci.2022.2.5
M. Ziaei, Mahjoubeh Keykha, F. Kazemi, A. Abdolrazaghnejad
Sedation is one of the most important criteria for eliciting the cooperation of young patients. The purpose of this study was to compare the sedative effect of oral administration of ketamine and midazolam in children admitted to an emergency department in Zahedan. In this double-blind clinical trial, children were placed in grades one and two according to the ASA status classification system. Then, they were randomized into two groups of 50 individuals each. One group received 0.5mg/kg midazolam and the other received 5 mg/kg ketamine. The medication was administered orally in both groups. The scores of children’s sedation and separation from their parents were recorded, and the obtained data were analyzed in SPSS using Chi-square test and independent t-test. The mean heart rate of patients before the intervention in the two groups had a slight difference, which was not statistically significant (P = 0.159). But after the intervention, this mean was significantly different in the two groups (P = 0.018). The mean scores of sedations and separation from the parent were not significantly different at 10, 20, and 30 minutes after medication in the two groups before and after the intervention. The mean length of hospitalization after sedation in the two groups differed significantly (p = 0.007) in the ketamine group (28.62 minutes) and the midazolam group (34.04 minutes). In the ketamine group, the mean heart rate decreased less after the intervention and the length of hospital stay was shorter compared with the midazolam group. Also, the percentage of children who showed earlier onset of sedation (20 minutes after taking the drug) was higher [in the ketamine group]. Therefore, ketamine seems more desirable for treatment and radiographic procedures in the emergency department.
{"title":"Comparing the Sedative Effect of Oral Midazolam versus Oral Ketamine on Children Aged 1-7 Years in Need of Radiologic Procedures","authors":"M. Ziaei, Mahjoubeh Keykha, F. Kazemi, A. Abdolrazaghnejad","doi":"10.26655/jmchemsci.2022.2.5","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.2.5","url":null,"abstract":"Sedation is one of the most important criteria for eliciting the cooperation of young patients. The purpose of this study was to compare the sedative effect of oral administration of ketamine and midazolam in children admitted to an emergency department in Zahedan. In this double-blind clinical trial, children were placed in grades one and two according to the ASA status classification system. Then, they were randomized into two groups of 50 individuals each. One group received 0.5mg/kg midazolam and the other received 5 mg/kg ketamine. The medication was administered orally in both groups. The scores of children’s sedation and separation from their parents were recorded, and the obtained data were analyzed in SPSS using Chi-square test and independent t-test. The mean heart rate of patients before the intervention in the two groups had a slight difference, which was not statistically significant (P = 0.159). But after the intervention, this mean was significantly different in the two groups (P = 0.018). The mean scores of sedations and separation from the parent were not significantly different at 10, 20, and 30 minutes after medication in the two groups before and after the intervention. The mean length of hospitalization after sedation in the two groups differed significantly (p = 0.007) in the ketamine group (28.62 minutes) and the midazolam group (34.04 minutes). In the ketamine group, the mean heart rate decreased less after the intervention and the length of hospital stay was shorter compared with the midazolam group. Also, the percentage of children who showed earlier onset of sedation (20 minutes after taking the drug) was higher [in the ketamine group]. Therefore, ketamine seems more desirable for treatment and radiographic procedures in the emergency department.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89934514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-13DOI: 10.26655/jmchemsci.2022.2.7
Jonny Army, Laurencia Violetta
The Corona-19 virus disease (Covid-19) continues to cause an increasing number of deaths, mainly due to acute respiratory disorders. The high pandemic mortality and morbidity prompted clinicians to seek suitable adjunctive therapeutic methods to eliminate high cytokine levels effectively. This study aimed to review the combined plasma filtration adsorption (CPFA) technology and its potential efficacy in treating critically ill Covid-19. CPFA combines plasma separation, adsorption, and hemofiltration techniques that meet the need to remove substances such as cytokines. Findings from the report suggest an immune dysregulation known as cytokine storm syndrome plays a role in severe and critically ill Covid-19 patients. Extracorporeal blood purification targets cytokine elimination and is preferred as a bridging strategy to improve survival. Combined adsorption plasma filtration (CPFA) can remove various substances, including cytokines, without depleting physiologically essential proteins. CPFA can be considered and assessed in clinical trials to treat critically ill Covid-19 patients. Paired Plasma Filtration Adsorption (PPFA) can be viewed as a potentially effective therapy in treating Covid-19 patients in critical condition.
{"title":"Coupled Plasma Filtration Adsorption as a Potential Therapy for Critically III Covid-19 Patients","authors":"Jonny Army, Laurencia Violetta","doi":"10.26655/jmchemsci.2022.2.7","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.2.7","url":null,"abstract":"The Corona-19 virus disease (Covid-19) continues to cause an increasing number of deaths, mainly due to acute respiratory disorders. The high pandemic mortality and morbidity prompted clinicians to seek suitable adjunctive therapeutic methods to eliminate high cytokine levels effectively. This study aimed to review the combined plasma filtration adsorption (CPFA) technology and its potential efficacy in treating critically ill Covid-19. CPFA combines plasma separation, adsorption, and hemofiltration techniques that meet the need to remove substances such as cytokines. Findings from the report suggest an immune dysregulation known as cytokine storm syndrome plays a role in severe and critically ill Covid-19 patients. Extracorporeal blood purification targets cytokine elimination and is preferred as a bridging strategy to improve survival. Combined adsorption plasma filtration (CPFA) can remove various substances, including cytokines, without depleting physiologically essential proteins. CPFA can be considered and assessed in clinical trials to treat critically ill Covid-19 patients. Paired Plasma Filtration Adsorption (PPFA) can be viewed as a potentially effective therapy in treating Covid-19 patients in critical condition.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77870209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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