B. Okuyan, F. Izzettin, Özlem Bingöl-Ozakpinar, P. Turan, Z. Ozdemir, M. Sancar, Z. Cirakli, P. Clark, F. Ercan
{"title":"The effects of Ginkgo biloba on nephrotoxicity induced by cisplatin-based chemotherapy protocols in rats","authors":"B. Okuyan, F. Izzettin, Özlem Bingöl-Ozakpinar, P. Turan, Z. Ozdemir, M. Sancar, Z. Cirakli, P. Clark, F. Ercan","doi":"10.18478/IUFSJB.02974","DOIUrl":null,"url":null,"abstract":"The study was aimed at investigating the possible renoprotective effects of Ginkgo biloba on nephrotoxicity \ninduced by cisplatin w/wo other antineoplastic agents (etoposide and gemcitabine) in rats. The \nanimals were randomly divided into eight groups each consisting of six rats. Serum blood urea nitrogen \n(BUN) and creatinine values at baseline and after drug administration, kidney malondialdehyde (MDA), \nglutathione (GSH) levels, and myeloperoxidase activity (MPO) were measured, and a histopathologic \nexamination of kidney tissues was carried out. Ginkgo biloba extract significantly decreased the serum \ncreatinine and kidney MDA levels, which had increased as a result of cisplatin administration and also \nimproved the depletion of kidney GSH levels in cisplatin administered rats (p<0.05). These results were \nconfirmed by histopathologic observations of the kidney tissues. According to the results of the present \nstudy, the potential interactions between the renoprotective agents and the cisplatin-based chemotherapeutic \nregimens must be considered. \nKeywords: Cisplatin- induced nephrotoxicity, Etoposide, Gemcitabine, Ginkgo biloba,","PeriodicalId":14521,"journal":{"name":"IUFS Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2012-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IUFS Journal of Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18478/IUFSJB.02974","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
The study was aimed at investigating the possible renoprotective effects of Ginkgo biloba on nephrotoxicity
induced by cisplatin w/wo other antineoplastic agents (etoposide and gemcitabine) in rats. The
animals were randomly divided into eight groups each consisting of six rats. Serum blood urea nitrogen
(BUN) and creatinine values at baseline and after drug administration, kidney malondialdehyde (MDA),
glutathione (GSH) levels, and myeloperoxidase activity (MPO) were measured, and a histopathologic
examination of kidney tissues was carried out. Ginkgo biloba extract significantly decreased the serum
creatinine and kidney MDA levels, which had increased as a result of cisplatin administration and also
improved the depletion of kidney GSH levels in cisplatin administered rats (p<0.05). These results were
confirmed by histopathologic observations of the kidney tissues. According to the results of the present
study, the potential interactions between the renoprotective agents and the cisplatin-based chemotherapeutic
regimens must be considered.
Keywords: Cisplatin- induced nephrotoxicity, Etoposide, Gemcitabine, Ginkgo biloba,