A Review on the Application of In Vitro and In Vivo Models of Cancerous Tumors for the Study of the Hyperthermia Effect

Zahra Zahedi-Tabar, S. Bagheri‐Khoulenjani, S. Amanpour, H. Mirzadeh
{"title":"A Review on the Application of In Vitro and In Vivo Models of Cancerous Tumors for the Study of the Hyperthermia Effect","authors":"Zahra Zahedi-Tabar, S. Bagheri‐Khoulenjani, S. Amanpour, H. Mirzadeh","doi":"10.18502/BCCR.V11I1.1653","DOIUrl":null,"url":null,"abstract":"Hyperthermia is a novel method for cancer therapy. To have the best control when heating tissues in hyperthermia, the use of magnetic nanoparticles is suggested. The local control of heat is very important in this technique, to prevent the damage of healthy tissues around the tumor, and therefore it is necessary to measure changes in temperature to determine the optimum conditions in which hyperthermia can create the desired results. The type and concentration of nanoparticles and nanoparticle distribution within the cancerous tissue are key factors affecting temperature distribution throughout the hyperthermia process. One of the main factors influencing nanoparticle distribution is the characteristics of the diffusion media, such as chemical composition, morphological and mechanical features, all of which affect the diffusion of nanoparticles at the cancer site. In this review, the most common in vitro and in vivo media and their influence on the results of hyperthermia are discussed. We also mention in silico as a computational model. Buffer solutions, cell cultures, microfluids, dead tissues and animal models are some of the in vitro media that are discussed in this review paper. In addition, some of the animal models used for hyperthermia will be mentioned.","PeriodicalId":8706,"journal":{"name":"Basic & Clinical Cancer Research","volume":"33 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Basic & Clinical Cancer Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/BCCR.V11I1.1653","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5

Abstract

Hyperthermia is a novel method for cancer therapy. To have the best control when heating tissues in hyperthermia, the use of magnetic nanoparticles is suggested. The local control of heat is very important in this technique, to prevent the damage of healthy tissues around the tumor, and therefore it is necessary to measure changes in temperature to determine the optimum conditions in which hyperthermia can create the desired results. The type and concentration of nanoparticles and nanoparticle distribution within the cancerous tissue are key factors affecting temperature distribution throughout the hyperthermia process. One of the main factors influencing nanoparticle distribution is the characteristics of the diffusion media, such as chemical composition, morphological and mechanical features, all of which affect the diffusion of nanoparticles at the cancer site. In this review, the most common in vitro and in vivo media and their influence on the results of hyperthermia are discussed. We also mention in silico as a computational model. Buffer solutions, cell cultures, microfluids, dead tissues and animal models are some of the in vitro media that are discussed in this review paper. In addition, some of the animal models used for hyperthermia will be mentioned.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
体外和体内肿瘤模型在热疗效应研究中的应用综述
热疗是一种治疗癌症的新方法。为了在热疗中加热组织时获得最佳控制,建议使用磁性纳米颗粒。局部热控制在该技术中非常重要,以防止肿瘤周围健康组织的损伤,因此有必要测量温度的变化,以确定热疗可以产生预期结果的最佳条件。在整个热疗过程中,纳米颗粒的类型和浓度以及纳米颗粒在癌组织内的分布是影响温度分布的关键因素。影响纳米颗粒分布的主要因素之一是扩散介质的特性,如化学成分、形态和力学特征,这些都影响纳米颗粒在肿瘤部位的扩散。本文综述了最常见的体外和体内介质及其对热疗结果的影响。我们也提到了计算机模型。缓冲液、细胞培养物、微液、死亡组织和动物模型是本文讨论的一些体外培养基。此外,还将提到一些用于热疗的动物模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
16
审稿时长
12 weeks
期刊最新文献
The Effect of Ursodeoxycholic acid and N-acetyl cysteine on Lymphoblast Viability Cross-Reacting Material 197, a Specific Inhibitor of HB-EGF, and Its Anticancer Effects Chronic Myeloid Leukemia in a Young Man with Unusual Presentation of Weight Loss, Bone Pain, and Abdominal Pain Effects of Gold Nanoparticles on Proton Therapy for Breast Cancer Cancer has an Independent Association with Death in Hospitalized Patients with COVID-19: A Single-center Study in Iran
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1