Niloufar Mohamadian, Mehdi Seyedmoradi, B. Izadi, F. Amirian, M. Ramezani
{"title":"Chronic Myeloid Leukemia in a Young Man with Unusual Presentation of Weight Loss, Bone Pain, and Abdominal Pain","authors":"Niloufar Mohamadian, Mehdi Seyedmoradi, B. Izadi, F. Amirian, M. Ramezani","doi":"10.18502/bccr.v13i1.8833","DOIUrl":null,"url":null,"abstract":"Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm and one of the main subtypes of leukemia that mainly affects adults. The incidence of CML increases slowly with age until the middle of the fourth decade, and then it rises rapidly. Anemia, splenomegaly, and constitutional symptoms are the most common signs and symptoms at presentation. Here we report a 27-year-old man with bone pain and generalized abdominal pain. He also had weight loss because of anorexia and easy satiety. The qualitative probe-based real-time PCR (qRT-PCR) result was positive for BCR-ABL1 (t9:22) P210 mutation. The patient was treated with Imatinib, the standard first-line treatment for CML, and showed clinical improvement. His pain also decreased, and he was discharged in good condition.","PeriodicalId":8706,"journal":{"name":"Basic & Clinical Cancer Research","volume":"97 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Basic & Clinical Cancer Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/bccr.v13i1.8833","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm and one of the main subtypes of leukemia that mainly affects adults. The incidence of CML increases slowly with age until the middle of the fourth decade, and then it rises rapidly. Anemia, splenomegaly, and constitutional symptoms are the most common signs and symptoms at presentation. Here we report a 27-year-old man with bone pain and generalized abdominal pain. He also had weight loss because of anorexia and easy satiety. The qualitative probe-based real-time PCR (qRT-PCR) result was positive for BCR-ABL1 (t9:22) P210 mutation. The patient was treated with Imatinib, the standard first-line treatment for CML, and showed clinical improvement. His pain also decreased, and he was discharged in good condition.
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