Finite-Element Modelling of the Acoustic Input Admittance of the Newborn Ear Canal and Middle Ear.

IF 3 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Archives of biochemistry and biophysics Pub Date : 2017-02-01 Epub Date: 2016-10-07 DOI:10.1007/s10162-016-0587-3
Hamid Motallebzadeh, Nima Maftoon, Jacob Pitaro, W Robert J Funnell, Sam J Daniel
{"title":"Finite-Element Modelling of the Acoustic Input Admittance of the Newborn Ear Canal and Middle Ear.","authors":"Hamid Motallebzadeh, Nima Maftoon, Jacob Pitaro, W Robert J Funnell, Sam J Daniel","doi":"10.1007/s10162-016-0587-3","DOIUrl":null,"url":null,"abstract":"<p><p>Admittance measurement is a promising tool for evaluating the status of the middle ear in newborns. However, the newborn ear is anatomically very different from the adult one, and the acoustic input admittance is different than in adults. To aid in understanding the differences, a finite-element model of the newborn ear canal and middle ear was developed and its behaviour was studied for frequencies up to 2000 Hz. Material properties were taken from previous measurements and estimates. The simulation results were within the range of clinical admittance measurements made in newborns. Sensitivity analyses of the material properties show that in the canal model, the maximum admittance and the frequency at which that maximum admittance occurs are affected mainly by the stiffness parameter; in the middle-ear model, the damping is as important as the stiffness in influencing the maximum admittance magnitude but its effect on the corresponding frequency is negligible. Scaling up the geometries increases the admittance magnitude and shifts the resonances to lower frequencies. The results suggest that admittance measurements can provide more information about the condition of the middle ear when made at multiple frequencies around its resonance.</p>","PeriodicalId":8174,"journal":{"name":"Archives of biochemistry and biophysics","volume":"383 2 1","pages":"25-48"},"PeriodicalIF":3.0000,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243259/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of biochemistry and biophysics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s10162-016-0587-3","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/10/7 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Admittance measurement is a promising tool for evaluating the status of the middle ear in newborns. However, the newborn ear is anatomically very different from the adult one, and the acoustic input admittance is different than in adults. To aid in understanding the differences, a finite-element model of the newborn ear canal and middle ear was developed and its behaviour was studied for frequencies up to 2000 Hz. Material properties were taken from previous measurements and estimates. The simulation results were within the range of clinical admittance measurements made in newborns. Sensitivity analyses of the material properties show that in the canal model, the maximum admittance and the frequency at which that maximum admittance occurs are affected mainly by the stiffness parameter; in the middle-ear model, the damping is as important as the stiffness in influencing the maximum admittance magnitude but its effect on the corresponding frequency is negligible. Scaling up the geometries increases the admittance magnitude and shifts the resonances to lower frequencies. The results suggest that admittance measurements can provide more information about the condition of the middle ear when made at multiple frequencies around its resonance.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
新生儿耳道和中耳声输入导纳的有限元建模
导纳测量是评估新生儿中耳状况的一种很有前途的工具。然而,新生儿耳朵在解剖学上与成人耳朵有很大不同,声输入导纳也与成人不同。为了帮助理解这些差异,我们开发了新生儿耳道和中耳的有限元模型,并研究了其在最高 2000 Hz 频率下的行为。材料特性来自以前的测量和估计。模拟结果在新生儿临床导纳测量的范围之内。材料特性的敏感性分析表明,在耳道模型中,最大导纳和出现最大导纳的频率主要受刚度参数的影响;在中耳模型中,阻尼与刚度一样重要,都会影响最大导纳的大小,但对相应频率的影响可以忽略不计。放大几何尺寸会增加导纳幅度,并将共振移至较低频率。结果表明,在中耳共振附近的多个频率上进行导纳测量,可以提供更多有关中耳状况的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Archives of biochemistry and biophysics
Archives of biochemistry and biophysics 生物-生化与分子生物学
CiteScore
7.40
自引率
0.00%
发文量
245
审稿时长
26 days
期刊介绍: Archives of Biochemistry and Biophysics publishes quality original articles and reviews in the developing areas of biochemistry and biophysics. Research Areas Include: • Enzyme and protein structure, function, regulation. Folding, turnover, and post-translational processing • Biological oxidations, free radical reactions, redox signaling, oxygenases, P450 reactions • Signal transduction, receptors, membrane transport, intracellular signals. Cellular and integrated metabolism.
期刊最新文献
Identification of an N-methylpyrazole derivative as a selective inhibitor of breast cancer resistance protein (BCRP/ABCG2) Echinoderm collagen as a neuromodulatory antioxidant: biochemical characterization and molecular interaction with NMDA receptor Unlocking ferroptosis: A novel link between triple-negative breast cancer and immune regulation Discovery and functional validation of a gut microbiota-metabolite-miRNA axis in diabetic encephalopathy BHMT Prevents renal ischemia/reperfusion injury via suppressing ROS-induced apoptosis by targeting NOX4.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1