Modulating muscle activity using GABA inhibitors

Abstract

Introduction: Overuse of muscles, stress and dehydration are some of the reasons for muscle spasms. Muscle cramps often resolve on their own but in some cases medical intervention is required. Aim: The aim of this article is to study the modulating muscle activity using GABA inhibitors. Materials and Methods: Treatment plans for bruxism include different ways for modulating muscle activity, which should be studied. Results: A spasm is an involuntary, unexpected contraction of one or more muscles. Muscle spasms can happen in any muscle of the human body. The most common reasons for the occurrence of spasms are overuse of a muscle, dehydration or stress. Discussion: Gamma-aminobutyric acid (GABA) serves as the main inhibitory neurotransmitter in the developed, mature central nervous system of mammals. GABA A receptors are ligand-activated chloride chan-nels. GABA receptors are the main focus of this study because of their wide spread throughout the mam-malian nervous system. In a recent study from 2017, Gervasi, Sisti and team from Baltimore discovered that the regular application of thiocolchicoside-based foam topically on m. rectus et biceps femoris reduced the risk of muscle cramps, muscle pain and improved the overall performance of the athletes in the study group. Conclusion: This discovery, along with the known properties of thiocolchicoside and its structure, present an interesting perspective when considering new ways to treat muscle spasms. Dermal patches ensure the gradual release of a substance in a certain area through the skin. The idea is to develop a dermal patch for application on m. masseter et temporalis when treating patients with bruxism.