Comparative and Interactive Studies of Aqueous Leaf Extracts of Ocimum gratissimum Linn. (Lamiaeceae),Vitamins C and E on the Basal Serum Phosphatase Levels of Male Guinea Pigs

West African journal of pharmacology and drug research Pub Date : 2010-09-06 DOI:10.4314/WAJPDR.V24I1.59051

J. Aprioku, A. Obianime

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引用次数: 10

Abstract

The present study was designed to investigate the comparative effects of aqueous leaf extract of Ocimum gratissimum Linn. (Lamiaceae), vitamin C and vitamin E on the basal serum phosphatases- alkaline phosphatase (ALP), total acid phosphatase (ACPT) and prostatic acid phosphatase (ACPP) of the male guinea-pig. Also investigated were the interactive effects of these agents on the biochemical parameters. Adult male guinea-pigs were divided into nineteen groups of five animals each and orally administered with different doses of O. gratissimum (11-352 mg/kg), vitamin C (1.25-80 mg/kg), vitamin E (75-2400mg/kg) and the last group (control) was given distilled water. Animals were sacrificed after 4h and blood samples collected and analyzed for ALP, ACPT, and ACPP. In another set of animals, O. gratissimum was administered 1h before obtaining the dose-responses of vitamins C and E and vice versa. O. gratissimum (11-352mg/kg), vitamin C (1.25-80mg/kg) and vitamin E (75-2400mg/kg) caused significant (p Keywords: Ocimum gratissimum , basal phosphatase, vitamin C and vitamin E.

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竹叶水提物的比较及相互作用研究。维生素C和E对雄性豚鼠基础血清磷酸酶水平的影响

本研究旨在研究山茱萸叶水提物的比较作用。维生素C和维生素E对雄性豚鼠基础血清磷酸酶碱性磷酸酶(ALP)、总酸性磷酸酶(ACPT)和前列腺酸性磷酸酶(ACPP)的影响。还研究了这些药剂对生化参数的相互作用。将成年雄性豚鼠分为19组，每组5只，分别口服不同剂量的黄貂草(11 ~ 352 mg/kg)、维生素C (1.25 ~ 80 mg/kg)、维生素E (75 ~ 2400mg/kg)，最后一组(对照组)给予蒸馏水。4h后处死动物，采集血样分析ALP、ACPT和ACPP。在另一组动物中，在获得维生素C和E的剂量反应前1小时给药，反之亦然。关键词:茴香(11 ~ 352mg/kg)、维生素C (1.25 ~ 80mg/kg)和维生素E (75 ~ 2400mg/kg)对(p)有显著影响。

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West African journal of pharmacology and drug research

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