A Review on Various Analytical Methodologies of Naproxen

Abstract

Naproxen is a Nonsteroidal Anti-Inflammatory Drug (NSAID). It is mostly used to treat pain or inflammation caused by conditions such as arthritis, gout, tendinitis or menstrual cramps. Naproxen is available in isolated dose with various similar anti-inflammatory drugs, i.e.; esomeprazole, pantoprazole, paracetamol, ranitidine, sumatriptan and ibuprofen. This survey evaluates various methods for the analysis of Naproxen in bulk drugs and formulated products. Analytical procedures are critical for determining compositions, they allow as to obtain both qualitative and quantitative results utilizing by the advanced analytical tools. This include HPLC, HPTLC, UV- spectrophotometry, capillary electrophoresis, and electrochemical meth-ods. The UV-spectrophotometry method is applied for the investigation of Naproxen in biologi-cal media, bulk samples and in various dosage formulations. The HPLC technique of Naproxen alone and the combination, including parameters such as matrix, stationary phase, mobile phase, wavelength detection, etc. HPTLC method parameters such as stationary phase, mobile combi-nation phase, RF value, etc. To maintain high commercial product quality standards and to ad-here to regulatory requirements, analytical technique development is necessary. Drug concen-trations are measured using bioanalytical techniques. Development and validation of bioanalyt-ical method is important to understand the pharmacokinetics of any drug and/or its metabolites.