Iron-Deficiency Anemias Worsen Some Cardiovascular Diseases: The Role of Intravenous Ferric Carboxymaltose

C. F
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Abstract

Background: Anemia induced by iron deficiency is a frequent co-morbidity of cardiovascular disease and is called as sideropenic anaemia. This is caused by low iron serum levels, with reduction of the hemoglobin value. Methods: Iron-deficiency reduces the oxygen carry throughout the body. The reduction of oxygen supply to the cardiac and pulmonary systems can point out some clinical symptoms, such as precordial angor, dyspnea, tachycardia and edema at lower limbs. It also induces an increase of some hemodynamic data, such as pulmonary and capillary pressures and worsens the prognosis of patients subjected to cardiac surgery. Results: Several data confirm that iron deficiency exerts detrimental effects in patients with coronary artery disease, heart failure, pulmonary hypertension and in those undergoing cardiac surgery. Conclusions: Iron deficiency further worsen the outcome and the complications of some cardiovascular disease. In addition, the manner and the advantages of i.v. iron administration (ferric carboxymaltose especially) were displayed. This administration may be requested in some conditions of cardiovascular disease and in the coexistence of these with kidney failure.
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缺铁性贫血加重一些心血管疾病:静脉注射羧麦芽糖铁的作用
背景:缺铁引起的贫血是心血管疾病的常见合并症,被称为铁缺乏性贫血。这是由于低铁血清水平,降低血红蛋白值。方法:缺铁会减少全身的氧气携带。心、肺系统供氧减少,可提示心前心绞痛、呼吸困难、心动过速、下肢水肿等临床症状。它还会引起一些血流动力学数据的增加,如肺动脉和毛细血管压力,并使心脏手术患者的预后恶化。结果:一些数据证实,铁缺乏对冠状动脉疾病、心力衰竭、肺动脉高压患者和接受心脏手术的患者有不利影响。结论:缺铁可使某些心血管疾病的预后和并发症进一步恶化。此外,还介绍了体外给铁(特别是羧基麦芽糖铁)的方法和优点。在某些心血管疾病和这些疾病与肾衰竭共存的情况下,可能需要这种给药。
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