Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status

Abstract

Objective: In order to discuss the correlation between thyroid function stratification and autoantibody titer in HT patients under different iodine nutritional status. Methods: The serum TH, antibody and urinary iodine levels were measured by the electrochemical immune-luminescent apparatus and iodine-catalyzed arsenic-cerium method in 100 HT patients (HT-A, HT-B, HT-C) with different thyroid functions and 60 healthy subjects. Results: The urinary iodine level of HT patients from HT-A increased in turn along with the progression of the disease, while the levels of FT3, FT4, TT3, TT4 decreased gradually and the levels of TSH and thyroid autoantibodies increased gradually. The urinary iodine level of HT-C group was negatively correlated with the serum FT3, FT4, TT3 and TT4 (P<0.05), while the urinary iodine level of HT-B group was negatively correlated with the serum FT3 and TT4 (P<0.05), and positively correlated with TSH (P<0.05). Along with the progression of HT disease, the levels of serum TPOAb and TGAb increased successively, and there were significant differences among each group (P<0.01). The serum TSH level of high TPOAb group and high TgAb group were respectively higher than those of low TPOAb group, low TgAb group and the control group, the levels of FT3 and FT4 were respectively lower than the low TPOAb group and low TGAb group, but there were no statistically significant on the differences between the FT3 of low TgAb and the levels of T3 and T4 of the control group, high TPOAb group, high TGAb group, low TPOAb group and low TGAb group. Conclusions: Under different iodine nutritional status, if the TH and autoantibody levels of HT patients with different thyroid functions changed correspondingly, it could indicate that the iodine nutritional status is involved in the occurrence and development process of HT of different thyroid functions and antibody levels, and plays an important role in it.