Quantitative assessment of specific serum IgGs may verify source of environmental exposure in extrinsic allergic alveolitis (EAA)

M. Sterclova, V. Kremláčková, Veronika Mottlová, Magdalena Brůžová, P. Sojka, M. Vašáková
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引用次数: 1

Abstract

Abstract Abstract:  Assessment of humoral response to inhalation antigens is currently the most frequently used method to confirm exposure. It may be useful in extrinsic allergic alveolitis (EAA) patients, especially in cases that are unaware of the source of exposure. However, commercially available test may not include relevant antigens, which may lead to false negativity of the test. We proposed that testing patient serological responses to antigens from respectively environments might be useful in showing the relevance of these exposures. Ten patients diagnosed with EAA were included in the case-control study. Samples from potentially harmful environments were collected, and antigenic extracts were prepared and used for enzyme-linked immunosorbent assays (ELISA) to investigate serological responses to suspected antigens. Plasma samples of unexposed volunteers were used as controls. The results were interpreted in the context of other clinical findings when known (e.g., radiologic patterns, bronchoalveolar lavage fluid findings, histology results) and patient history. We suggest that environmental sampling may provide more information than previous history assessment and commercially available specific IgGs tests and helps to either reveal hidden exposures or find relevant exposure in cases with multiple potential sources. The results of these tests must be interpreted carefully in the context of other clinical data.
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定量评估特异性血清igg可验证外源性变应性肺泡炎(EAA)的环境暴露源。
摘要摘要:评估吸入抗原的体液反应是目前确认暴露最常用的方法。它可能对外源性过敏性肺泡炎(EAA)患者有用,特别是在不知道暴露源的情况下。然而,市售的测试可能不包括相关抗原,这可能导致测试的假阴性。我们提出,测试患者对抗原的血清学反应从不同的环境可能是有用的,以显示这些暴露的相关性。10例诊断为EAA的患者纳入病例对照研究。从可能有害的环境中收集样本,制备抗原提取物并用于酶联免疫吸附试验(ELISA),以调查对可疑抗原的血清学反应。未暴露志愿者的血浆样本作为对照。结果应结合已知的其他临床表现(如放射学表现、支气管肺泡灌洗液表现、组织学结果)和患者病史进行解释。我们认为,环境采样可能比以往的病史评估和商业上可获得的特定igg测试提供更多的信息,并有助于揭示隐藏的暴露或在有多个潜在来源的情况下找到相关的暴露。这些试验的结果必须在其他临床数据的背景下仔细解释。
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