A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines

Çağla Begüm Apaydın, Z. Cesur
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引用次数: 8

Abstract

DOI : 10.26650/IstanbulJPharm.2019.19002 This report is about an unexpected formation of N,N’-bis(substituted phenoxyacetyl) hydrazine derivatives. The reaction between N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide with sulfanyl acids to obtain 4-thiazolidinones s,  gave an unexpected product, N,N’-bis(phenoxyacetyl)hydrazine, with high purity instead of the expected cyclocondensation product.  When repeating the reaction with p-toluenesulfonic acid under the same conditions, the reaction resulted in the same compound. This indicates that two molecules of N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide were involved in the reaction. The reaction can be applied as a different and new procedure for the synthesis of several N,N’-bis(substituted phenoxyacetyl)hydrazine derivatives.  Cite this article as: Apaydin CB, Cesur Z (2019). A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines. Istanbul J Pharm 49 (2): 61-63.
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合成N,N ' -双(苯氧乙酰基)肼的新方法
这份报告是关于N,N ' -双(取代苯氧乙酰基)肼衍生物的意外形成。N′-(4-乙基环己基)苯氧乙酰肼与磺胺酸反应得到4-噻唑烷酮,得到了意想不到的产物N,N′-双(苯氧乙酰基)肼,取代了预期的高纯度环缩合产物。在相同条件下与对甲苯磺酸重复反应,得到相同的化合物。这表明两分子N ' -(4-乙基环己基)苯氧乙酰肼参与了反应。该反应可作为合成N,N ' -双(取代苯氧乙酰基)肼衍生物的新方法。本文引自:刘建军,刘建军(2019)。合成N,N ' -双(苯氧乙酰基)肼的新方法。中华医学杂志,49(2):61-63。
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