Pub Date : 2023-12-28DOI: 10.26650/istanbuljpharm.2023.1181298
S. Isik, A. G. Usman, S. Abba
{"title":"A chemometrics-based approach for the determination of thymoquinone from Nigella sativa L. (Black Cumin) seeds of different geographical regions using the HPLC technique","authors":"S. Isik, A. G. Usman, S. Abba","doi":"10.26650/istanbuljpharm.2023.1181298","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2023.1181298","url":null,"abstract":"","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.26650/istanbuljpharm.2023.1229554
Selin Engür Öztürk
{"title":"Pro-inflammatory ‘M1 macrophage’ vs anti-inflammatory ‘Hydrocortisone’ a new approach to wound healing in HaCaT cells","authors":"Selin Engür Öztürk","doi":"10.26650/istanbuljpharm.2023.1229554","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2023.1229554","url":null,"abstract":"","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.26650/istanbuljpharm.2023.1068742
U. Magaji, Özlem Saçan, R. Yanardağ
{"title":"Inhibitory potentials of Moringa oleifera on activities of neuraminidase, xanthine oxidase and adenosine deaminase","authors":"U. Magaji, Özlem Saçan, R. Yanardağ","doi":"10.26650/istanbuljpharm.2023.1068742","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2023.1068742","url":null,"abstract":"","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.26650/istanbuljpharm.2023.1167417
Didem Yilmaz Oral, Alev Önder, Serap Gür
{"title":"Ameliorative effect of cranberry on erectile function in diabetic rats","authors":"Didem Yilmaz Oral, Alev Önder, Serap Gür","doi":"10.26650/istanbuljpharm.2023.1167417","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2023.1167417","url":null,"abstract":"","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.26650/istanbuljpharm.2023.1197571
Hüseyin Portakal
{"title":"Virtual drug screening for p65/rela subunit of nf-κb: Promising repurposable drugs in the treatment of stress-based diseases","authors":"Hüseyin Portakal","doi":"10.26650/istanbuljpharm.2023.1197571","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2023.1197571","url":null,"abstract":"","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.26650/istanbuljpharm.2023.1363930
Hasan Şahin, İçim Gökkaya, Nurdan Yazici Bektaş
{"title":"Attitudes and perceptions of pharmacy students toward pharmacognosy and related competencies of the national core education program in Türkiye","authors":"Hasan Şahin, İçim Gökkaya, Nurdan Yazici Bektaş","doi":"10.26650/istanbuljpharm.2023.1363930","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2023.1363930","url":null,"abstract":"","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.26650/istanbuljpharm.2023.1277041
Esra Aysel, Türkan Yurdun
{"title":"Analysis of selected steroid hormones in sea of Marmara sediment samples by LC-ESI/MS-MS","authors":"Esra Aysel, Türkan Yurdun","doi":"10.26650/istanbuljpharm.2023.1277041","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2023.1277041","url":null,"abstract":"","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.26650/istanbuljpharm.2023.1268289
Deniz Ulukuș, O. Tugay
{"title":"Taxonomic significance of anatomy and achene micromorphology of selected Cousinia Cass. species (Asteraceae)","authors":"Deniz Ulukuș, O. Tugay","doi":"10.26650/istanbuljpharm.2023.1268289","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2023.1268289","url":null,"abstract":"","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-28DOI: 10.26650/istanbuljpharm.2023.1269175
Hüseyin İstanbullu, Ezgi Turunc, Sami Hamdoun, Merve Saylam, H. Koyu, Tijen Kaya Temiz
{"title":"The investigation of drug repurposing for HDAC1 inhibitory effects by in silico and in vitro methods","authors":"Hüseyin İstanbullu, Ezgi Turunc, Sami Hamdoun, Merve Saylam, H. Koyu, Tijen Kaya Temiz","doi":"10.26650/istanbuljpharm.2023.1269175","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2023.1269175","url":null,"abstract":"","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139218954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01DOI: 10.26650/istanbuljpharm.2019.19035
M. E. Okur, N. Karakaş, A. Karadaǧ, Damla Uludağ, D. Polat
DOI : 10.26650/IstanbulJPharm.2019.19035 Opuntia ficus-indica fruits are claimed to possess several health-beneficial properties. This study was carried out to determine the phytochemicals as well as to compare antioxidant activity and cell viability of the methanol extract of OFI-fruits. Antioxidant activity was evaluated by various in vitro tests such as DPPH, ABTS. Furthermore LC-MS and HPLC analysis were performed. The activity of the OFI-fruit extract on viability of U87-MG (glioblastoma multiform), HT-29 (colon cancer) and human primary fibroblast cells has been investigated by determining viable cells on a luciferase based system (Cell TiterGlo; Promega;USA). The results showed that OFI-fruits were source of antioxidant compounds. Moreover, the extract was found to have rich phenolic-flavonoid contents. Quercetin was found in the extract according to LC-MS and HPLC studies. The remarkable increased cell death in the HT-29 and U87 cell lines was detected in a concentration-dependent manner (1-10mg/ml). Among these cell lines, HT-29 responded to OFI-fruit treatment more sensitively to even the lowest dose (1mg/ml). The results of this study showed the OFI-fruit has significant antioxidant capacity and leads to strong cytotoxic activity on various cancer cells. Therefore, it can be suggested that OFI-fruits may have chemo-preventive potential and can be studied further to clarify cytotoxic abilities. You may cite this article as : Okur ME, Karakas N, Karadag AE, Uludag D, Polat DC (2019). Investigation of Antioxidant and Cytotoxic Activities of Opuntia ficus-indica (L.) Mill. Fruit extract. Istanbul J Pharm 10.26650/IstanbulJPharm.2019.19035.
{"title":"Investigation of Antioxidant and Cytotoxic Activities of Opuntia ficus-indica (L.) Mill. Fruit extract","authors":"M. E. Okur, N. Karakaş, A. Karadaǧ, Damla Uludağ, D. Polat","doi":"10.26650/istanbuljpharm.2019.19035","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.19035","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19035 Opuntia ficus-indica fruits are claimed to possess several health-beneficial properties. This study was carried out to determine the phytochemicals as well as to compare antioxidant activity and cell viability of the methanol extract of OFI-fruits. Antioxidant activity was evaluated by various in vitro tests such as DPPH, ABTS. Furthermore LC-MS and HPLC analysis were performed. The activity of the OFI-fruit extract on viability of U87-MG (glioblastoma multiform), HT-29 (colon cancer) and human primary fibroblast cells has been investigated by determining viable cells on a luciferase based system (Cell TiterGlo; Promega;USA). The results showed that OFI-fruits were source of antioxidant compounds. Moreover, the extract was found to have rich phenolic-flavonoid contents. Quercetin was found in the extract according to LC-MS and HPLC studies. The remarkable increased cell death in the HT-29 and U87 cell lines was detected in a concentration-dependent manner (1-10mg/ml). Among these cell lines, HT-29 responded to OFI-fruit treatment more sensitively to even the lowest dose (1mg/ml). The results of this study showed the OFI-fruit has significant antioxidant capacity and leads to strong cytotoxic activity on various cancer cells. Therefore, it can be suggested that OFI-fruits may have chemo-preventive potential and can be studied further to clarify cytotoxic abilities. You may cite this article as : Okur ME, Karakas N, Karadag AE, Uludag D, Polat DC (2019). Investigation of Antioxidant and Cytotoxic Activities of Opuntia ficus-indica (L.) Mill. Fruit extract. Istanbul J Pharm 10.26650/IstanbulJPharm.2019.19035.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90538827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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