Successfully healthy baby delivery from human refrozen blastocyst embryos by vitrification

Tomomi Takahashi, Y. Araki
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引用次数: 11

Abstract

To demonstrate delivery by using re-vitrified blastocysts derived from supernumerary embryos in the event of an unsuccessful pregnancy attempt. Nine early stage cleaved embryos were frozen by vitrification, and subsequently thawed. Four of the nine embryos developed to the blastocyst stage. Two of the four blastocysts were transferred, and two supernumerary good embryos remained unexpectedly, and they were refrozen by vitrification under consent. Subsequently, one of the re-vitrified embryos developed to 38 weeks and was delivered by cesarean section (a health female; 46, XX). The transfer of re-vitrified supernumerary blastocysts resulted in a successful pregnancy and delivery outcome. This study suggests that re-vitrification is one rescue procedure which allows the re-use of supernumerary embryos in patients who failed to have a pregnancy after frozen embryo transfer.
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通过玻璃化技术成功地将人类再冷冻囊胚移植至健康婴儿
在妊娠尝试失败的情况下,通过使用来自多余胚胎的再玻璃化囊胚来证明分娩。9个早期裂解胚胎通过玻璃化冷冻,随后解冻。9个胚胎中有4个发育到了囊胚期。四个囊胚中的两个被移植,意外地留下了两个多余的好胚胎,在征得同意的情况下,它们被玻璃化冷冻。随后,其中一个重新玻璃化的胚胎发育到38周,并通过剖宫产分娩(一名健康女性;重新玻璃化的多余囊胚移植导致了成功的妊娠和分娩结果。这项研究表明,重新玻璃化是一种抢救程序,允许在冷冻胚胎移植后未能怀孕的患者重复使用多余胚胎。
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