Synthesis of Novel Symmetrical and Unsymmetrical o-Phthalic Acid Diamides

P. Kumar, Y. D. Reddy, C. V. Reddy, B. Devi, P. Dubey
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引用次数: 1

Abstract

Phthalic anhydride was treated with secondary amines in acetic acid yielding 2-(diethyl (or) 4-alkylpiperazine or morpholine-1-carbonyl) benzoic acids. The latter were reacted, again, with secondary amines and arylamines by using the coupling reagent HATU and Et3N as a base in DMF giving the novel symmetrical o-phthalic acid diamides , unsymmetrical o-phthalic acid diamides , and primary amidic-secondary amidic containing unsymmetrical o-phthalic acid diamides , respectively.
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新型对称和不对称邻苯二甲酸二胺的合成
邻苯二酸酐在乙酸中与仲胺反应,得到2-(二乙基(或)4-烷基哌嗪或1-羰基)苯甲酸。在DMF中,以偶联剂HATU和Et3N为碱,再次与仲胺和芳胺反应,分别得到新型对称邻苯二甲酸二胺、不对称邻苯二甲酸二胺和含不对称邻苯二甲酸二胺的伯胺-仲酰胺。
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