The Tgf-β1 Over Expression has Major Impact on Multilineage Differentiation of Mesenchymal Stromal Cells

Abstract

with a superior capacity for self-renewal, and are capable of differentiating into adipocytes, osteoblasts, chondrocytes [1,2]. In these days, MSCs have been broadly used in regenerative medicine [3]. Dental Pulp-derived Mesenchymal Stem Cells (DPSCs) have become a popular research topic in that they are similar too the rmesenchymal stem cells, easy to obtain and are used in regenerative medicine and tissue engineering [4]. In vitro and in vivo studies have been previously performed to understand the biology of DPSCs. The differentiation of mesenchymal stem cells usually involves the use of signaling factors as recombinant proteins or gene therapy that an functionally activate genes [5]. Transforming Growth Factor Beta 1 (TGF-β1) activates mainly SMAD transcription factors with complex cellular responses [6]. The superior proliferative ability and regenerative potential are primary phenotypes of MSCs [7].