Pub Date : 2023-09-22DOI: 10.24966/srdt-2060/100104
J Lacy Kamm
Our research investigated the interaction of the cell-mediated and innate arms of the immune system with allogeneic Mesenchymal Stromal Cells (MSCs). This study monitored population changes and activation of Equine Leukocyte Antigen (ELA) - mismatched leukocytes in direct co-culture with MSCs. Cytotoxic T cells, helper T cells, regulatory T cells, B cells and neutrophils were identified using flow cytometry
{"title":"Short Review on Immune Response to Allogeneic Equine Mesenchymal Stromal Cells","authors":"J Lacy Kamm","doi":"10.24966/srdt-2060/100104","DOIUrl":"https://doi.org/10.24966/srdt-2060/100104","url":null,"abstract":"Our research investigated the interaction of the cell-mediated and innate arms of the immune system with allogeneic Mesenchymal Stromal Cells (MSCs). This study monitored population changes and activation of Equine Leukocyte Antigen (ELA) - mismatched leukocytes in direct co-culture with MSCs. Cytotoxic T cells, helper T cells, regulatory T cells, B cells and neutrophils were identified using flow cytometry","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-22DOI: 10.24966/srdt-2060/100107
Wuyi Kong, XiuJuan Han, XiaoPing Zhu, Hong Wang
We previously identified three distinct pre-stem cell lineages that further develop into blood CD34-positive stem cells, and mesenchymal stem cells. The pre-CD34-positive stem cells are spore-like, while the pre-mesenchymal stem cells are fusiform-shaped. All of them originate or released from tube-shaped tissue structures, or niches. In the current study, we present two membrane-like pre-stem progenitors
{"title":"Development of Membrane-Like Pre-Stem Cells after Released from Tube-Shaped Niches","authors":"Wuyi Kong, XiuJuan Han, XiaoPing Zhu, Hong Wang","doi":"10.24966/srdt-2060/100107","DOIUrl":"https://doi.org/10.24966/srdt-2060/100107","url":null,"abstract":"We previously identified three distinct pre-stem cell lineages that further develop into blood CD34-positive stem cells, and mesenchymal stem cells. The pre-CD34-positive stem cells are spore-like, while the pre-mesenchymal stem cells are fusiform-shaped. All of them originate or released from tube-shaped tissue structures, or niches. In the current study, we present two membrane-like pre-stem progenitors","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-22DOI: 10.24966/srdt-2060/100106
Mike KS Chan, Michelle BF Wong, Thomas Skutella, Roni Moya, Dmytro Klokol
Thymus plays a crucial role in immune system development and T-cell maturation. With aging, thymus activity declines, which leads to a weakened immune system and an increased risk of infections and cancer. In recent years, thymus extract has gained attention as a potential treatment for cancer and anti-aging. Studies have suggested that thymus extract can stimulate the production of T-cells and enhance immune function, which may lead to improved outcomes in cancer patients
{"title":"Clinical Experience of Thymic Regeneration with Thymus Extracts, Thymic Peptides and Stem Cells in General Medicine, Oncology and Anti-Aging Medicine: A Review","authors":"Mike KS Chan, Michelle BF Wong, Thomas Skutella, Roni Moya, Dmytro Klokol","doi":"10.24966/srdt-2060/100106","DOIUrl":"https://doi.org/10.24966/srdt-2060/100106","url":null,"abstract":"Thymus plays a crucial role in immune system development and T-cell maturation. With aging, thymus activity declines, which leads to a weakened immune system and an increased risk of infections and cancer. In recent years, thymus extract has gained attention as a potential treatment for cancer and anti-aging. Studies have suggested that thymus extract can stimulate the production of T-cells and enhance immune function, which may lead to improved outcomes in cancer patients","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-22DOI: 10.24966/srdt-2060/100105
Sara Steffanoni
Consolidation therapy demonstrated to improve the outcome of naïve patients affected by Primary Central Nervous System Lymphoma (PCNSL). In the past, Whole Brain Radiotherapy (WBRT) represented the standard consolidation approach for PCNSL in response after high dose methotrexate-based induction chemotherapy
{"title":"Autologous stem cell transplantation in Primary Central Nervous System Lymphoma: A Systematic Review","authors":"Sara Steffanoni","doi":"10.24966/srdt-2060/100105","DOIUrl":"https://doi.org/10.24966/srdt-2060/100105","url":null,"abstract":"Consolidation therapy demonstrated to improve the outcome of naïve patients affected by Primary Central Nervous System Lymphoma (PCNSL). In the past, Whole Brain Radiotherapy (WBRT) represented the standard consolidation approach for PCNSL in response after high dose methotrexate-based induction chemotherapy","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.24966/srdt-2060/100086
Yehonatan Zur, Tzila Davidov, L. Baruch, M. Machluf
Aiming to restore the normal function of diseased or injured tissues, regenerative therapy approaches are generally based on the engineering of complex tissue-mimicking grafts, encompassing biomaterial scaffolds, stem cells, or their combinations [1-4]. Due to the major role of stem cells in physiological regenerative mechanisms, regenerative therapies normally rely on either stem cells transplantation or stem cell recruitment from the neighboring tissue into the implanted scaffold
{"title":"Extracellular Matrix Scaffolds - A Tissue-Specific Bioactive Niche for Stem Cells in Regenerative Therapy","authors":"Yehonatan Zur, Tzila Davidov, L. Baruch, M. Machluf","doi":"10.24966/srdt-2060/100086","DOIUrl":"https://doi.org/10.24966/srdt-2060/100086","url":null,"abstract":"Aiming to restore the normal function of diseased or injured tissues, regenerative therapy approaches are generally based on the engineering of complex tissue-mimicking grafts, encompassing biomaterial scaffolds, stem cells, or their combinations [1-4]. Due to the major role of stem cells in physiological regenerative mechanisms, regenerative therapies normally rely on either stem cells transplantation or stem cell recruitment from the neighboring tissue into the implanted scaffold","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73238622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.24966/srdt-2060/100082
J. Baumgartner, Linda S. Baumgartner
Sensorineural Hearing Loss (SNHL) continues to be a significant public health problem with over 270 million affected people worldwide and an incidence that increases with age [1,2]. Some cases of SNHL have a genetic cause, but the majority of SHNL is the result of ototoxic insult [3]
{"title":"Regenerative Therapy for Sensorineural Hearing Loss: Recent Progress and Future Directions","authors":"J. Baumgartner, Linda S. Baumgartner","doi":"10.24966/srdt-2060/100082","DOIUrl":"https://doi.org/10.24966/srdt-2060/100082","url":null,"abstract":"Sensorineural Hearing Loss (SNHL) continues to be a significant public health problem with over 270 million affected people worldwide and an incidence that increases with age [1,2]. Some cases of SNHL have a genetic cause, but the majority of SHNL is the result of ototoxic insult [3]","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"28 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72469812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.24966/srdt-2060/100084
M. Serafini, Sara Di Teodoro, Luisa Romondio, L. Zagaria
The purpose of this clinical case report is to describe a full-arch rehabilitation with one to one endosseous implant restoration. Although the proposed treatment may not be within the financial means of most patients, the aesthetical result is higher because of the close similarity between the final restorations and the natural dentition.
{"title":"Upper Full Rehabilitation with One to One Immediate Loading Implants: A Case Report","authors":"M. Serafini, Sara Di Teodoro, Luisa Romondio, L. Zagaria","doi":"10.24966/srdt-2060/100084","DOIUrl":"https://doi.org/10.24966/srdt-2060/100084","url":null,"abstract":"The purpose of this clinical case report is to describe a full-arch rehabilitation with one to one endosseous implant restoration. Although the proposed treatment may not be within the financial means of most patients, the aesthetical result is higher because of the close similarity between the final restorations and the natural dentition.","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73839362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.24966/srdt-2060/100080
Castro A. Gonzalez
Alzheimer’s disease is the most prevalent neurodegenerative disorder in the elderly population. The patients suffer cerebral atrophyas a consequence of extensive neuronal loss, especially in areas that play a role in memory and cognition. Cell therapies approaches have emerged as promising treatments to regenerate the brain tissue of the patients
{"title":"Introducing New Neurons in the Alzheimer’s Disease Brain","authors":"Castro A. Gonzalez","doi":"10.24966/srdt-2060/100080","DOIUrl":"https://doi.org/10.24966/srdt-2060/100080","url":null,"abstract":"Alzheimer’s disease is the most prevalent neurodegenerative disorder in the elderly population. The patients suffer cerebral atrophyas a consequence of extensive neuronal loss, especially in areas that play a role in memory and cognition. Cell therapies approaches have emerged as promising treatments to regenerate the brain tissue of the patients","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75618201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.24966/srdt-2060/100088
Sophia Shaka, Nicolas Carpo, Victoria Tran, Carlos Cepeda, A. Espinosa‐Jeffrey
There are two approaches used to study the effects of microgravity on cells -- using simulated microgravity on Earth (sim-µG) or sending cells to space (SPC-µG). We have recently reported that human neural stem cells (NSCs) proliferated seven-times more while in space than Ground Control (GC) NSCs on Earth. Here, using time-lapse microscopy, we determined that in both sim-µG and SPC-µG there are two cell subpopulations distinguished by differences in somatic diameter
{"title":"Microgravity Significantly Influences Neural Stem Cells Size and Numbers: Implications for Long-term Space Missions","authors":"Sophia Shaka, Nicolas Carpo, Victoria Tran, Carlos Cepeda, A. Espinosa‐Jeffrey","doi":"10.24966/srdt-2060/100088","DOIUrl":"https://doi.org/10.24966/srdt-2060/100088","url":null,"abstract":"There are two approaches used to study the effects of microgravity on cells -- using simulated microgravity on Earth (sim-µG) or sending cells to space (SPC-µG). We have recently reported that human neural stem cells (NSCs) proliferated seven-times more while in space than Ground Control (GC) NSCs on Earth. Here, using time-lapse microscopy, we determined that in both sim-µG and SPC-µG there are two cell subpopulations distinguished by differences in somatic diameter","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85947052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.24966/srdt-2060/100083
M. Domaniža, A. Trbolová, M. Hluchý, D. Čížková
Osteoarthritis (OA) is Degenerative Joint Disease (DJD) associated with pain, inflammation and cartilage degradation resulting in lameness. This state is irreversible and actual conventional therapies are not able to provide regeneration of damaged tissue. Current therapies, mainly NSAIDs, have many adverse effects and are not able to stop degenerative process
{"title":"Mesenchymal Stem Cell-Based Treatment of Osteoarthritis in Dogs - A Review","authors":"M. Domaniža, A. Trbolová, M. Hluchý, D. Čížková","doi":"10.24966/srdt-2060/100083","DOIUrl":"https://doi.org/10.24966/srdt-2060/100083","url":null,"abstract":"Osteoarthritis (OA) is Degenerative Joint Disease (DJD) associated with pain, inflammation and cartilage degradation resulting in lameness. This state is irreversible and actual conventional therapies are not able to provide regeneration of damaged tissue. Current therapies, mainly NSAIDs, have many adverse effects and are not able to stop degenerative process","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75213941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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