The trans-Sialidase from Trypanosoma cruzi a Putative Target for Trypanocidal Agents

Abstract

Trypanosomatid protozoa are parasites of considerable medical and economical importance because they are the causative agents of chronic human and livestock diseases endemic in developing countries. Trypanosoma cruzi is the causative agent of Chagasdisease, present in most of Latin America. The biology of this parasite presents some unusual features, one of which is the mechanism employed for the addition of sialic acid units to its own glycoproteins, the mucin- like molecules, or to exogenous glycoconjugates. This is mediated by a transglycosylase for sialic acid known as trans- sialidase and located on the external surface of the parasite, rather than by an intracellular CMP-sialic acid-dependent sia- lyltransferase. The Trypanosoma cruzi trans-sialidase is thought to play an important role in the pathogenesis of Chagas' disease, and it represents a potential therapeutic target.