Oral Administration of LBKV-3 as Probiotic Enhances Immunoglobulin Level and Faecal Microflora in Malnutrate Children

Abstract

Role of probiotics in regulation of immune system and development in microflora has begun to implicate in humans and animals. Inconsistent data exist regarding the effect of a single probiotic strain in malnutrate children. The aim of this study clinically proven Lactobacillus acidophilus strain LBKV-3 intended as probiotc for human was used to test its effect on modulation of immunoglobulin and composition of faecal microflora. To accomplish this task, 135 malnutrate children were orally administrated with buffalo milk as control, fresh curd as a special module for assessment of stimulatory effects and probiotic acidophilus milk used as a probiotic. During feeding, we evaluate the level of saliva IgA, serum IgG and IgE and faecal microflora. The result of our study demonstrated that the frequency of immunoglobulin and microflora was not affected when children consumed buffalo milk. In presence of fresh curd, the level of IgA, IgG and composition of friendly bacteria slightly increases and proportion of pathogenic bacteria declines. However, probiotic acidophilus milk significantly triggers the level of IgA and IgG as well as population of helpful bacteria rises and concentration of pathogenic bacteria declines in comparison to fresh curd. Irrespective of IgA and IgG, the ratio of IgE reduces in presence of fresh curd and probiotic acidophilus milk. Thus, our study showed that probiotic has positive effects on modulation of immunoglobulin and regulation of gut microflora. To confirm these findings, large-scale experiments involving the use of a large number of humans of different age groups and under different health and nutritional condition are required to be performed. Moreover, a different dose or strain of probiotic also warrants further confirmation.