The Biological Potential and Synthetic Diversity of 1,3,4-Oxadiazole Multiplexed with Various Heterocyclic Compounds

R. K, Deevan Paul Amarnath, Hariraj Narayanan, Adhya Das
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Abstract

Countless bioactive compounds are having the oxadiazole nucleus showing clinical and biological applications. Oxadiazole is a heterocyclic compound of the azole family that has gained increasing attention due to its wide therapeutic potential. Many significant synthetic medicinal compounds have the oxadiazole scaffold, which provided a good treatment idea and binds with high affinity to a variety of receptors to aid in the development of novel beneficial derivatives. Numerous researchers have worked to create novel oxadiazole compounds and evaluate them for how they affect inflammation, tumor, epilepsy, microbial infections, and analgesic properties. The present review article summarizes some of the oxadiazole derivatives synthesized and their biological activities and can be a useful guide for researchers working on this scaffold.
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1,3,4-恶二唑与各种杂环化合物复合的生物学潜力和合成多样性
无数具有恶二唑核的生物活性化合物显示出临床和生物学上的应用。恶二唑是一种杂环化合物,由于其广泛的治疗潜力而受到越来越多的关注。许多重要的合成药物化合物都含有恶二唑支架,它提供了一个很好的治疗思路,并且与多种受体具有高亲和力结合,有助于开发新的有益衍生物。许多研究人员致力于创造新的恶二唑化合物,并评估它们如何影响炎症、肿瘤、癫痫、微生物感染和镇痛特性。本文综述了一些恶二唑类衍生物的合成及其生物活性,以期对该支架的研究有一定的指导意义。
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