Jamıl Anwar, A. Dar, Ramna Mumtaz, J. Anzano, Ayesha Mohyuddin
Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain or inflammation due to osteoarthritis or rheumatoid arthritis. Assay of piroxicam in pharmaceutical formulations can be performed by using a number of analytical techniques. This work estimates the drug in commercial samples using a novel method, Computational Image Scanning Densitometry (CISD). Micro-volumes of the aqueous solution of piroxicam were reacted with iron(III) sulfate solution under optimum conditions on a white Teflon well plate to form a pink-colored mononuclear complex. By using a smartphone, the picture of the colored complex in the well plate was taken and transferred to an attached computer. The overall optical density resulting from red, green, and blue (RGB) components from a specific area of the colored image was measured and digitalized with the help of custom-made software. A standard curve was prepared by plotting optical density against piroxicam concentration. The method was simple, fast, adequately precise, and accurate for the assay of the drug in commercial samples. The validity of the new method was checked by comparing the results with those obtained by a standard spectrophotometric method of Piroxicam estimation.
{"title":"Microdetermination of Piroxicam in Pharmaceutical Formulations by Complexation with Fe(III) and Image Scanning Densitometry","authors":"Jamıl Anwar, A. Dar, Ramna Mumtaz, J. Anzano, Ayesha Mohyuddin","doi":"10.18596/jotcsa.1391053","DOIUrl":"https://doi.org/10.18596/jotcsa.1391053","url":null,"abstract":"Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain or inflammation due to osteoarthritis or rheumatoid arthritis. Assay of piroxicam in pharmaceutical formulations can be performed by using a number of analytical techniques. This work estimates the drug in commercial samples using a novel method, Computational Image Scanning Densitometry (CISD). Micro-volumes of the aqueous solution of piroxicam were reacted with iron(III) sulfate solution under optimum conditions on a white Teflon well plate to form a pink-colored mononuclear complex. By using a smartphone, the picture of the colored complex in the well plate was taken and transferred to an attached computer. The overall optical density resulting from red, green, and blue (RGB) components from a specific area of the colored image was measured and digitalized with the help of custom-made software. A standard curve was prepared by plotting optical density against piroxicam concentration. The method was simple, fast, adequately precise, and accurate for the assay of the drug in commercial samples. The validity of the new method was checked by comparing the results with those obtained by a standard spectrophotometric method of Piroxicam estimation.","PeriodicalId":17299,"journal":{"name":"Journal of the Turkish Chemical Society Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141837826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nowadays, with excessive use due to rapid population growth, growing industry, and technological developments, environmental pollution is also increasing and is reaching a point where it threatens the health of humans. The alarming increase in environmental pollution is mostly seen in the form of water pollution. Water pollution has reached levels that threaten human health. There are difficulties in accessing clean water in many parts of the world as a result of restricting the use of natural water resources polluted by both human activities and natural causes. Therefore, intense efforts are made to remove especially heavy metals and other harmful substances that pollute water. Among these toxic heavy metals threatening the health of humans, arsenic is at the top of the list as the most dangerous one. In recent years, many methods and techniques have been developed in addition to classical methods for removing pollutants from water. In this study, conventional methods used in the treatment of arsenic-contaminated waters, the difficulties encountered in the removal process, and the advantages and disadvantages of the methods were critically reviewed in the light of current and past information. In addition, detailed comparative information is given about nano-sized adsorbents, which is an innovative approach used in the adsorption method, one of the arsenic removal methods.
{"title":"New Generation Nanoadsorbents and Conventional Techniques for Arsenic Removal from Waters","authors":"Veyis Karakoç, Erol Erçağ","doi":"10.18596/jotcsa.1438869","DOIUrl":"https://doi.org/10.18596/jotcsa.1438869","url":null,"abstract":"Nowadays, with excessive use due to rapid population growth, growing industry, and technological developments, environmental pollution is also increasing and is reaching a point where it threatens the health of humans. The alarming increase in environmental pollution is mostly seen in the form of water pollution. Water pollution has reached levels that threaten human health. There are difficulties in accessing clean water in many parts of the world as a result of restricting the use of natural water resources polluted by both human activities and natural causes. Therefore, intense efforts are made to remove especially heavy metals and other harmful substances that pollute water. Among these toxic heavy metals threatening the health of humans, arsenic is at the top of the list as the most dangerous one. In recent years, many methods and techniques have been developed in addition to classical methods for removing pollutants from water. In this study, conventional methods used in the treatment of arsenic-contaminated waters, the difficulties encountered in the removal process, and the advantages and disadvantages of the methods were critically reviewed in the light of current and past information. In addition, detailed comparative information is given about nano-sized adsorbents, which is an innovative approach used in the adsorption method, one of the arsenic removal methods.","PeriodicalId":17299,"journal":{"name":"Journal of the Turkish Chemical Society Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140398614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: The province of Burdur is at the forefront of the livestock industry, especially with dairy cattle. it is a necessity for Burdur province to use animal manure, convert it into methane gas, and use it as fuel. In this study, a laboratory-scale biodigester was set up to produce biogas from cattle feces taken from Burdur Mehmet Akif Ersoy University Cattle Farm. γ-Fe2O3, meso-Fe2O3, and meso-Co3O4 nanoparticles (NPs) were synthesized and used as catalysts for biogas production. Structural characterizations of catalysts were carried out via FT-IR and XRD techniques. The TEM was used to investigate particle size distributions and morphology. The average particle sizes of the nanoparticles were determined to be in the range of 20-165 nm. The bio-digester was kept at a constant temperature of 35 °C for 20 days. It has been determined that the obtained biogas has a high methane content of 83–86%. The biogas volume was obtained to be 1.360 L/kg for γ-Fe2O3, 1.390 L/kg for meso-Fe2O3, and 625-1.250 L/kg for Co3O4.
{"title":"Enhancing Biogas Production with The Addition of Nano-catalysts","authors":"Fatih Emen, Aslıhan CESUR TURGUT, Şevkinaz Doğan","doi":"10.18596/jotcsa.1368040","DOIUrl":"https://doi.org/10.18596/jotcsa.1368040","url":null,"abstract":": The province of Burdur is at the forefront of the livestock industry, especially with dairy cattle. it is a necessity for Burdur province to use animal manure, convert it into methane gas, and use it as fuel. In this study, a laboratory-scale biodigester was set up to produce biogas from cattle feces taken from Burdur Mehmet Akif Ersoy University Cattle Farm. γ-Fe2O3, meso-Fe2O3, and meso-Co3O4 nanoparticles (NPs) were synthesized and used as catalysts for biogas production. Structural characterizations of catalysts were carried out via FT-IR and XRD techniques. The TEM was used to investigate particle size distributions and morphology. The average particle sizes of the nanoparticles were determined to be in the range of 20-165 nm. The bio-digester was kept at a constant temperature of 35 °C for 20 days. It has been determined that the obtained biogas has a high methane content of 83–86%. The biogas volume was obtained to be 1.360 L/kg for γ-Fe2O3, 1.390 L/kg for meso-Fe2O3, and 625-1.250 L/kg for Co3O4.","PeriodicalId":17299,"journal":{"name":"Journal of the Turkish Chemical Society Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140452453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Umoru, Mohammad Lawal, O. A. Babatunde, Yusuf Sahabi
The degradation of tolonium chloride (TC+) dye by phosphate ion (PO43-) in an aqueous acidic solution was studied using spectrophotometric analysis at 301 K, I= 1.0 M, [TC+]= 1.5 × 10-5 M, [H+]= 1.0×10-3 M, and ʎmax 600 nm. To determine the potency and rate of the reactant species, an aqueous acidic medium was employed. The reaction's direction and tendency were predicted using a thermodynamic analysis at an interval of 5.0 K and a temperature range of 301-321 K. Without the presence of intermediate complex/free atoms formation, a reaction that produced phenyl sulphoxide, phenylamine, and HPO32- as products of the reaction was obtained with a molar ratio of 1:1 for both reactants. First-order tolonium chloride reactivity was found in the reaction and first-order for the phosphate ion, resulting in a second-order reaction overall. The reaction process accelerated as the concentration of hydrochloric acid rose. The response time decreased with an increase in ionic strength concentration and added Ca2+ and Cl- did catalyze the reaction positively. A straight line that went through the origin was produced by plotting 1/ko vs PO43- concentration. The spectroscopic analysis showed no discernible shift from λmax of 600 nm. Additionally, an increase in temperature accelerated the reaction process. The reaction has a negative free energy change, G (-3.13–1.12 KJ/mol) which indicates that it is spontaneous and that the reactants have more free energy than that of the products. While the enthalpy of activation, H is positive and indicates that the reaction was endothermic and followed an associative path, the entropy of activation, S, is also negative (-7.45–1.10 KJ/mol), indicating that the reaction is less disordered. Due to the added ions catalysis and absence of free atoms during the course of the reaction, an outer-sphere mechanism was suggested for the reaction.
{"title":"Degradation of Tolonium Chloride Dye by Phosphate Ion in Aqueous Acidic Solution: Kinetic Approach","authors":"P. Umoru, Mohammad Lawal, O. A. Babatunde, Yusuf Sahabi","doi":"10.18596/jotcsa.1362644","DOIUrl":"https://doi.org/10.18596/jotcsa.1362644","url":null,"abstract":"The degradation of tolonium chloride (TC+) dye by phosphate ion (PO43-) in an aqueous acidic solution was studied using spectrophotometric analysis at 301 K, I= 1.0 M, [TC+]= 1.5 × 10-5 M, [H+]= 1.0×10-3 M, and ʎmax 600 nm. To determine the potency and rate of the reactant species, an aqueous acidic medium was employed. The reaction's direction and tendency were predicted using a thermodynamic analysis at an interval of 5.0 K and a temperature range of 301-321 K. Without the presence of intermediate complex/free atoms formation, a reaction that produced phenyl sulphoxide, phenylamine, and HPO32- as products of the reaction was obtained with a molar ratio of 1:1 for both reactants. First-order tolonium chloride reactivity was found in the reaction and first-order for the phosphate ion, resulting in a second-order reaction overall. The reaction process accelerated as the concentration of hydrochloric acid rose. The response time decreased with an increase in ionic strength concentration and added Ca2+ and Cl- did catalyze the reaction positively. A straight line that went through the origin was produced by plotting 1/ko vs PO43- concentration. The spectroscopic analysis showed no discernible shift from λmax of 600 nm. Additionally, an increase in temperature accelerated the reaction process. The reaction has a negative free energy change, G (-3.13–1.12 KJ/mol) which indicates that it is spontaneous and that the reactants have more free energy than that of the products. While the enthalpy of activation, H is positive and indicates that the reaction was endothermic and followed an associative path, the entropy of activation, S, is also negative (-7.45–1.10 KJ/mol), indicating that the reaction is less disordered. Due to the added ions catalysis and absence of free atoms during the course of the reaction, an outer-sphere mechanism was suggested for the reaction.","PeriodicalId":17299,"journal":{"name":"Journal of the Turkish Chemical Society Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140457307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study reports the synthesis of copolymers that contain thermally responsive polymers, namely poly(N-isopropylacrylamide) (PNIPAM) and poly(2-ethyl-2-oxazoline) (PEOX), as well as biodegradable side groups that are water-soluble and capable of hydrogen bonding. The assay aims to produce heat-responsive PNIPAM and PEOX polymers with di-carboxylic acid (DCA) controlled structuring of the resulting pH-sensitive nano-structured polymers. These will be used as a template in the synthesis of inorganic materials. The study demonstrated the impact of pH, salt concentration, and temperature on the polymer/DCA. This fragment describes the functional groups of the thermosensitive polymers PNIPAM and PEOX. These polymers have carboxylic acid functional groups at both ends, are water soluble, and are capable of hydrogen bonding. The structure of these polymers can be recognized with small molecules of DCA in an aqueous solution at different pH, salt concentrations, and temperatures with H-bonds. Additionally, these polymers can be used as templates to synthesize hollow silica polymers. The synthesized monomers and polymers were structurally characterized using Fourier transform infrared spectrophotometer (FT-IR). The resulting structured polymers were identified by scanning electron microscopy and atomic force microscopy (SEM, AFM). UV-VIS spectrophotometer and Differential Scanning Calorimetry (DSC) were used to determine the Lower Critical Solution temperature of the polymers.
{"title":"Preparation of Poly (N-Isopropylacrylamide) -Poly (2-Ethyl-2-Oxazoline) and Their Self-Assembly Properties with Dicarboxylic Acid","authors":"Perihan YİLMAZ ERDOGAN, F. Bilge Emre, T. Seçkin","doi":"10.18596/jotcsa.1150117","DOIUrl":"https://doi.org/10.18596/jotcsa.1150117","url":null,"abstract":"This study reports the synthesis of copolymers that contain thermally responsive polymers, namely poly(N-isopropylacrylamide) (PNIPAM) and poly(2-ethyl-2-oxazoline) (PEOX), as well as biodegradable side groups that are water-soluble and capable of hydrogen bonding. The assay aims to produce heat-responsive PNIPAM and PEOX polymers with di-carboxylic acid (DCA) controlled structuring of the resulting pH-sensitive nano-structured polymers. These will be used as a template in the synthesis of inorganic materials. The study demonstrated the impact of pH, salt concentration, and temperature on the polymer/DCA. This fragment describes the functional groups of the thermosensitive polymers PNIPAM and PEOX. These polymers have carboxylic acid functional groups at both ends, are water soluble, and are capable of hydrogen bonding. The structure of these polymers can be recognized with small molecules of DCA in an aqueous solution at different pH, salt concentrations, and temperatures with H-bonds. Additionally, these polymers can be used as templates to synthesize hollow silica polymers. The synthesized monomers and polymers were structurally characterized using Fourier transform infrared spectrophotometer (FT-IR). The resulting structured polymers were identified by scanning electron microscopy and atomic force microscopy (SEM, AFM). UV-VIS spectrophotometer and Differential Scanning Calorimetry (DSC) were used to determine the Lower Critical Solution temperature of the polymers.","PeriodicalId":17299,"journal":{"name":"Journal of the Turkish Chemical Society Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140461739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this study was to investigate the rapid, simple, and inexpensive biosynthesis and characterization of gold nanoparticles (AuNPs) an extract from leaves of Morus alba L. The generated gold nanoparticles were characterized by UV-Vis spectroscopy, TEM, FT-IR and zeta-sizer. For the biogenesis of gold nanoparticles, Morus alba L. (Mulberry) leaves and HAuCl4.3H2O solution were utilized as the starting ingredients. Fresh leaves of Morus alba L. were collected from Turkey (Trabzon). 100 mL of distilled water was mixed with 10 g of dried material for 120 minutes. The mixture was then extracted using a laboratory microwave for 4 minutes at 600 W. For the biosynthesis of AuNPs, different amounts 100 ml of (0.5 mM, 1 mM) aqueous HAuCl4.3H2O solution of leaf extract (0.5 and 1 mL) were mixed with HAuCl4. 3H2O solution, and then the mixture was placed in a household microwave at 90 W for 1 to 30 minutes. UV-vis spectroscopy, TEM, FT-IR and zeta-sizer were performed to characterize the produced gold nanoparticles. UV-Vis absorption spectra was measured using a Shimadzu UV-1240 UV-Vis spectrophotometer with a wave length range of 300 to 800 nm. The development of AuNPs was indicated by the mixture's purple-red colour. From the results of zetasizer study, the average particle size of the AuNPs was 78.95±0.57 nm, the zeta potential was 12.9±0.808 mV, and the polydispersity index was 0.321±0.004. When the AuNP solutions were kept in the refrigerator, their UV-Vis absorption spectra rarely changed and remained stable for around 2 to 2.5 months.
{"title":"Biogenic Synthesis and Characterization of Gold Nanoparticles from Morus alba L. Leaves by Microwave Extraction Method","authors":"Gönül Serdar","doi":"10.18596/jotcsa.1372302","DOIUrl":"https://doi.org/10.18596/jotcsa.1372302","url":null,"abstract":"The aim of this study was to investigate the rapid, simple, and inexpensive biosynthesis and characterization of gold nanoparticles (AuNPs) an extract from leaves of Morus alba L. The generated gold nanoparticles were characterized by UV-Vis spectroscopy, TEM, FT-IR and zeta-sizer. For the biogenesis of gold nanoparticles, Morus alba L. (Mulberry) leaves and HAuCl4.3H2O solution were utilized as the starting ingredients. Fresh leaves of Morus alba L. were collected from Turkey (Trabzon). 100 mL of distilled water was mixed with 10 g of dried material for 120 minutes. The mixture was then extracted using a laboratory microwave for 4 minutes at 600 W. For the biosynthesis of AuNPs, different amounts 100 ml of (0.5 mM, 1 mM) aqueous HAuCl4.3H2O solution of leaf extract (0.5 and 1 mL) were mixed with HAuCl4. 3H2O solution, and then the mixture was placed in a household microwave at 90 W for 1 to 30 minutes. UV-vis spectroscopy, TEM, FT-IR and zeta-sizer were performed to characterize the produced gold nanoparticles. UV-Vis absorption spectra was measured using a Shimadzu UV-1240 UV-Vis spectrophotometer with a wave length range of 300 to 800 nm. The development of AuNPs was indicated by the mixture's purple-red colour. From the results of zetasizer study, the average particle size of the AuNPs was 78.95±0.57 nm, the zeta potential was 12.9±0.808 mV, and the polydispersity index was 0.321±0.004. When the AuNP solutions were kept in the refrigerator, their UV-Vis absorption spectra rarely changed and remained stable for around 2 to 2.5 months.","PeriodicalId":17299,"journal":{"name":"Journal of the Turkish Chemical Society Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nemadectin, a macrocyclic lactone of the milbemycin class, is a fermentation by-product of the bacteria Streptomyces cyanogriseus subsp. non-Cyanogenus. Moxidectin is a semi-synthetic derivative of nemadectin. River blindness, also known as onchocerciasis, is treated with moxidectin in patients 12 years of age and older. This condition is brought on by the parasitic worm Onchocerca volvulus and is subjected to intense itching, skin conditions that are disfiguring, and impaired vision brought on by the larvae of the worm. Some of the most common internal and exterior parasites are killed by moxidectin by selectively binding to their glutamate-gated chloride ion channels. In this review article, various pieces of equipment, such as a UV spectrometer, HPLC, LC-MS, and UPLC-MS, are used to determine moxidectin as well as its related compounds. The QuEChERS method was also used in the sample preparation according to the literature survey. The report also offers an overview of the pharmacodynamics, pharmacokinetics, and medication interactions of moxidectin.
{"title":"A Review on Different Analytical Techniques for Quantification of Moxidectin","authors":"Aarti Kommu, Raja Sundararajan","doi":"10.18596/jotcsa.1257065","DOIUrl":"https://doi.org/10.18596/jotcsa.1257065","url":null,"abstract":"Nemadectin, a macrocyclic lactone of the milbemycin class, is a fermentation by-product of the bacteria Streptomyces cyanogriseus subsp. non-Cyanogenus. Moxidectin is a semi-synthetic derivative of nemadectin. River blindness, also known as onchocerciasis, is treated with moxidectin in patients 12 years of age and older. This condition is brought on by the parasitic worm Onchocerca volvulus and is subjected to intense itching, skin conditions that are disfiguring, and impaired vision brought on by the larvae of the worm.\u0000Some of the most common internal and exterior parasites are killed by moxidectin by selectively binding to their glutamate-gated chloride ion channels. In this review article, various pieces of equipment, such as a UV spectrometer, HPLC, LC-MS, and UPLC-MS, are used to determine moxidectin as well as its related compounds. The QuEChERS method was also used in the sample preparation according to the literature survey. The report also offers an overview of the pharmacodynamics, pharmacokinetics, and medication interactions of moxidectin.","PeriodicalId":17299,"journal":{"name":"Journal of the Turkish Chemical Society Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
De novo drug design has been studied utilizing the organic chemical structures of Salmon Calcitonin 9 - 19 and Peptide Nucleic Acid (PNA) to suppress Coronavirus Ribonucleic Acid (RNA)-Glycoprotein complex. PNA has a polyamide backbone and Thymine pendant groups to selectively bind and inhibit Adenine domains of the RNA-Glycoprotein complex. While doing so, molecular docking and molecular dynamics studies revealed that there is great inhibition docking energy (-12.1 kcal/mol) with significantly good inhibition constant (124.1 µM) values confirming the efficient nucleotide-specific silencing of Coronavirus RNA-Glycoprotein complex.
{"title":"De novo Drug Design to Suppress Coronavirus RNA-Glycoprotein via PNA-Calcitonin","authors":"Soykan Agar, B. Akkurt, Levent Alparslan","doi":"10.18596/jotcsa.1406290","DOIUrl":"https://doi.org/10.18596/jotcsa.1406290","url":null,"abstract":"De novo drug design has been studied utilizing the organic chemical structures of Salmon Calcitonin 9 - 19 and Peptide Nucleic Acid (PNA) to suppress Coronavirus Ribonucleic Acid (RNA)-Glycoprotein complex. PNA has a polyamide backbone and Thymine pendant groups to selectively bind and inhibit Adenine domains of the RNA-Glycoprotein complex. While doing so, molecular docking and molecular dynamics studies revealed that there is great inhibition docking energy (-12.1 kcal/mol) with significantly good inhibition constant (124.1 µM) values confirming the efficient nucleotide-specific silencing of Coronavirus RNA-Glycoprotein complex.","PeriodicalId":17299,"journal":{"name":"Journal of the Turkish Chemical Society Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The main target of the present paper is to investigate the effect of different acidic aqueous media(DAAM) on the synthesis of cadmium telluride thin films(CdTeTFm). The synthesis of CdTeTFm was carried out by the electrochemical deposition method(EDM) in DAAM. The chronoamperometry method of electrodeposition(ED) was used for the production of CdTeTFm. Furthermore, the electrochemical behaviors of the solutions were studied using cyclic voltammetry. The experiments were carried out with 3 electrodes (a working electrode (WE), a reference electrode(CE), and a counter electrode(RE)) using the electrochemical cell potentiostatic method. The experimental conditions of the acidic aqueous CdTe solution have been determined to be pH 3.56-3.57, the temperature of the solution is 85°C, the concentration of CdTe 2.45x10-1 M, and the reaction time is 25 minutes. The physical properties of CdTeTFm were determined by XRD, SEM/EDX, FT-IR, and UV-VIS analysis methods. According to the results of the analysis, it was observed that acidic aqueous media have an important role in the synthesis of CdTeTFm. The bandgap ranges and Cd/Te ratios of the synthesized thin films were obtained as 1.42, 1.48, 1.50, 1.58 eV, 0.65, 0.587, 0.79 and 0.738, respectively.
{"title":"Investigation of the Effects of Different H2SO4, HCI, HNO3 and HCIO4 Liquid Acid Media on the Synthesis of CdTe Semiconductor Thin Films for Solar Cells","authors":"Ayça KIYAK YILDIRIM, Veli Şimşek","doi":"10.18596/jotcsa.1285341","DOIUrl":"https://doi.org/10.18596/jotcsa.1285341","url":null,"abstract":"The main target of the present paper is to investigate the effect of different acidic aqueous media(DAAM) on the synthesis of cadmium telluride thin films(CdTeTFm). The synthesis of CdTeTFm was carried out by the electrochemical deposition method(EDM) in DAAM. The chronoamperometry method of electrodeposition(ED) was used for the production of CdTeTFm. Furthermore, the electrochemical behaviors of the solutions were studied using cyclic voltammetry. The experiments were carried out with 3 electrodes (a working electrode (WE), a reference electrode(CE), and a counter electrode(RE)) using the electrochemical cell potentiostatic method. The experimental conditions of the acidic aqueous CdTe solution have been determined to be pH 3.56-3.57, the temperature of the solution is 85°C, the concentration of CdTe 2.45x10-1 M, and the reaction time is 25 minutes. The physical properties of CdTeTFm were determined by XRD, SEM/EDX, FT-IR, and UV-VIS analysis methods. According to the results of the analysis, it was observed that acidic aqueous media have an important role in the synthesis of CdTeTFm. The bandgap ranges and Cd/Te ratios of the synthesized thin films were obtained as 1.42, 1.48, 1.50, 1.58 eV, 0.65, 0.587, 0.79 and 0.738, respectively.","PeriodicalId":17299,"journal":{"name":"Journal of the Turkish Chemical Society Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140497312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A de novo designed biomolecule called INASHD was utilized through computer-aided drug design techniques to specifically target β2-spectrin, effectively suppressing and preventing NASH disease. Advanced computational software tools concerning the technologies of molecular docking and molecular dynamics (MD), were employed to showcase the drug's remarkable ability to efficiently suppress and control the α-helical topology of β2-spectrin. This protein is a vital component within the disease pathway. We successfully devised an effective design suppressing β2-spectrin, exhibiting an inhibition score surpassing any other molecule documented in scientific literature. With robust support from validated computational software, this bioorganic structure holds significant value and can be applied for a patent due to its innovative design. It shows promising potential for delivering positive outcomes in various stages, including in vitro, in vivo, ex vivo, and human phase studies.
{"title":"New Drug Design to Suppress Nonalcoholic Steatohepatitis","authors":"Soykan Agar, B. Akkurt, E. Ulukaya","doi":"10.18596/jotcsa.1395403","DOIUrl":"https://doi.org/10.18596/jotcsa.1395403","url":null,"abstract":"A de novo designed biomolecule called INASHD was utilized through computer-aided drug design techniques to specifically target β2-spectrin, effectively suppressing and preventing NASH disease. Advanced computational software tools concerning the technologies of molecular docking and molecular dynamics (MD), were employed to showcase the drug's remarkable ability to efficiently suppress and control the α-helical topology of β2-spectrin. This protein is a vital component within the disease pathway. We successfully devised an effective design suppressing β2-spectrin, exhibiting an inhibition score surpassing any other molecule documented in scientific literature. With robust support from validated computational software, this bioorganic structure holds significant value and can be applied for a patent due to its innovative design. It shows promising potential for delivering positive outcomes in various stages, including in vitro, in vivo, ex vivo, and human phase studies.","PeriodicalId":17299,"journal":{"name":"Journal of the Turkish Chemical Society Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140498588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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