Ting Cong, Arielle J. Hall, Zhimeng Jia, A. Christiano, H. Elsevier, Zoe B. Cheung, Davis S. Wellman, David A. Forsh, J. Lane
{"title":"Conceptualizing Biological Aging and Frailty in Orthopaedics","authors":"Ting Cong, Arielle J. Hall, Zhimeng Jia, A. Christiano, H. Elsevier, Zoe B. Cheung, Davis S. Wellman, David A. Forsh, J. Lane","doi":"10.2106/JBJS.21.01053","DOIUrl":null,"url":null,"abstract":"➤ Biological aging can best be conceptualized clinically as a combination of 3 components: frailty, comorbidity, and disability.➤ Despite advancements in the understanding of senescence, chronological age remains the best estimate of biological age. However, a useful exercise for practitioners is to look beyond chronological age in clinical and surgical decision-making.➤ A chronologically aging person does not age biologically at the same rate.➤ The best way to understand frailty is to consider it as a physical phenotype.➤ Physical optimization should parallel medical optimization before elective surgery.➤ The poorer the host (both in terms of bone quality and propensity for healing), the more robust the implant construct must be to minimize reliance on host biology.","PeriodicalId":22579,"journal":{"name":"The Journal of Bone and Joint Surgery","volume":"54 1","pages":"1212 - 1222"},"PeriodicalIF":0.0000,"publicationDate":"2022-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Bone and Joint Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2106/JBJS.21.01053","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
➤ Biological aging can best be conceptualized clinically as a combination of 3 components: frailty, comorbidity, and disability.➤ Despite advancements in the understanding of senescence, chronological age remains the best estimate of biological age. However, a useful exercise for practitioners is to look beyond chronological age in clinical and surgical decision-making.➤ A chronologically aging person does not age biologically at the same rate.➤ The best way to understand frailty is to consider it as a physical phenotype.➤ Physical optimization should parallel medical optimization before elective surgery.➤ The poorer the host (both in terms of bone quality and propensity for healing), the more robust the implant construct must be to minimize reliance on host biology.
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