{"title":"PRO-INFLAMMATORY CYTOKINES IL-4 AND IL-13 IN CHILDREN WITH \"SECRETOR\" AND \"NON-SECRETOR\" STATUS OF H ANTIGEN DURING FOOD ALLERGY","authors":"N. Kosyakova, I. Prokhorenko","doi":"10.31618/esu.2413-9335.2021.1.91.1492","DOIUrl":null,"url":null,"abstract":"Analysis of peculiarities of production of inflammatory cytokines IL-4 and IL-13 in children with approved diagnosis \"food allergy\" with \"secretor\" and \"non-secretor\" H-antigen status was carried out. \"Non-secretor\" children were shown to have 1.7 times higher content of a Th2 inflammation marker, IL-4, in blood serum than children with \"secretor\" status. IL-13 content was also elevated, although not so significantly. In children with \"non-secretor\" status, higher level of pro-inflammatory cytokines correlated with more severe progression of allergic inflammation, which makes determination of H antigen in the saliva of children and their mothers a promising non-invasive prognostic marker of progression of allergic inflammation in children with food allergy.","PeriodicalId":11879,"journal":{"name":"EurasianUnionScientists","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"EurasianUnionScientists","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31618/esu.2413-9335.2021.1.91.1492","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Analysis of peculiarities of production of inflammatory cytokines IL-4 and IL-13 in children with approved diagnosis "food allergy" with "secretor" and "non-secretor" H-antigen status was carried out. "Non-secretor" children were shown to have 1.7 times higher content of a Th2 inflammation marker, IL-4, in blood serum than children with "secretor" status. IL-13 content was also elevated, although not so significantly. In children with "non-secretor" status, higher level of pro-inflammatory cytokines correlated with more severe progression of allergic inflammation, which makes determination of H antigen in the saliva of children and their mothers a promising non-invasive prognostic marker of progression of allergic inflammation in children with food allergy.
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