Effect Of Chlordiazepoxide Oral Tablet On Oral Recurrent Bruxism, A Clinical Trial Human Study

Abstract

Background: Oral recurrent bruxism is the most common disease of the oral cavity. The underlying etiology remains unclear, and no curative treatment is available. Chlordiazepoxide is essential and useful as anti-anxiety, sedative, appetite-stimulating and weak analgesic actions substance, which recent evidence indicates its involved in emotional responses. Objectives: The present study aimed to use systemic drug such as Chlordiazepoxide oral tablet (5mg). Illnesses related to the oral bruxism by studying its effects in oral recurrent bruxism, this systemic therapy is not indicated in such situation among other drugs. Methods: In this study patients presented with oral recurrent bruxism were treated with Chlordiazepoxide oral tablet (5mg) administered orally once daily after night meal . The dispersible tablet was administered orally once daily for 10 days, 66 participants, 7 were excluded due to incomplete records (51 males and 8 females aged 45.0±6 years) with oral recurrent bruxism, divided into two groups; group A, 30 patients were randomly assigned to receive Chlordiazepoxide oral tablet (5mg) once per day at night, and group B; 29 patients with oral placebo daily for 10 days. Results: The results showed that administering of Chlordiazepoxide oral tablet (5mg) accelerated the healing process within a short time period (10 days) without complications or disfigurement in all patients. Group A, 24 patients, (the healing rate were 0.79%) of 30 patients were used Chlordiazepoxide oral tablet (5mg) doses administered orally had complete healing of oral recurrent bruxism at period time eight days of enzyme‑linked immunosorbent assay investigation. Also there will be a decline both in salivary cortisol and salivary alpha-amylase (sAA)levels during the time period of the study, compared with group B, only 6 patients (the healing rate were 0.21%) of 29 placebo-randomized patients. Conclusion: In this study showed that, the Chlordiazepoxide oral tablet treatment was effective in healing the oral recurrent bruxism and the end-points of the study were complete healing and absence of any discomfort pain while eating within a short period of treatment.