Investigation of In Vivo Effects of Trichomonas Vaginalis on Visceral Organs

Akyshbayeva Kulbarshin, S. Elmira, Ramazanova Bakyt, Kushugulova Almagul, Khassenbekova Zhanagul, S. Sergazy, M. Alía
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Abstract

Background: Urogenital trichomoniasis (UGT) is the most common sexually transmitted disease in Kazakhstan. Association of T. vaginalis infection with the development of ascites and multiple visceral abscesses was shown in experiments with intraperitoneal injection of infectious material. The effect of T. vaginalis on visceral organs in natural infection is unknown. Materials and methods: T.vaginalis effect on visceral organs was assessed with the model previously developed by us ("The Method of Urogenital Trichomoniasis Simulation", patent application No. 06 331 dated April 1, 2016). It was ethically carried out on animals with the approval of the KazNMU Ethics Committee (Registration No. 191). The material for histological and cytological studies was prepared in accordance with the conventional methods. Result: The changes was found in all visceral organs, most pronounced in hepatic parenchyma: parenchymal degeneration and necrosis of hepatocytes, significant edema with cellular infiltration in the portal tracts and separation of blood plasma from the formed elements in blood vessels representing changes in rheological properties of blood. Expressed changes were also observed in renal tissues. Less pronounced changes were observed in lung tissues. Conclusions: The results of our study showed high activity of T. vaginalis in visceral organs.
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阴道毛滴虫体内对脏器影响的研究
背景:泌尿生殖道毛滴虫病是哈萨克斯坦最常见的性传播疾病。在腹腔注射感染性物质的实验中,阴道绦虫感染与腹水和多发内脏脓肿的发生有关。自然感染时阴道梭菌对内脏器官的影响尚不清楚。材料和方法:阴道滴虫对内脏器官的影响采用我们先前开发的模型进行评估(“泌尿生殖器滴虫病模拟方法”,专利申请号06331,2016年4月1日)。该实验在动物身上进行,并得到了KazNMU伦理委员会(注册号191)的批准。按照常规方法制备组织学和细胞学研究材料。结果:所有脏器均有改变,以肝实质最明显:肝实质变性和肝细胞坏死,门管区明显水肿伴细胞浸润,血浆与血管内形成元素分离,血液流变学特性发生改变。在肾组织中也观察到表达变化。肺组织的变化不太明显。结论:本研究结果显示阴道梭菌在内脏器官中具有较高的活性。
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