Synthesis, characterization and biological evaluation of Schiff’s bases derivatives as potent antibacterial agents

Pharmaceutical and Biological Evaluations Pub Date : 2017-10-02 DOI:10.26510/2394-0859.pbe.2017.34

V. Parcha, Ankith Kumar, B. Mahajan, J. Kaur

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引用次数: 2

Abstract

Objective : To design, synthesize and screen biologically newer Substituted Schiff bases by condensing substituted acid hydrazides with various benzaldehydes and explore their antimicrobial potential. Methods : Present study synthesis of various derivatives of Schiffs bases was carried out by: firstly converting substituted acids to acid hydrazides and then to Schiff's bases after condensation with substituted benzaldehyde. Synthesized compounds were characterised on the basis of spectral studies (like UV, IR, and NMR). All the synthesized derivatives were screened further for their antibacterial effect against Salmonella typhimurium, Shigella sonnei, Staphylococcus aureus& Bacillus cereus. Results : From this study it could be observed that schiff’s bases 2-[( aminophenylhydrazinyldene o,m,dinitrobenzoyl] aniline (H) and compound 2-[( aminophenylzinyldene) p amino benzoyl] aniline (I) showed very good zone of inhibition against almost all strains tested for. Conclusions : So further attempts could be made to extend the series and explore their antibacterial potential to achieve hopeful goal.

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席夫碱衍生物高效抗菌的合成、表征及生物学评价

目的:通过与各种苯甲醛缩合取代酸肼设计、合成和筛选生物学上较新的取代希夫碱，并探索其抗菌潜力。方法:本研究采用先将取代酸转化为酸酰肼，再与取代苯甲醛缩合为席夫碱的方法合成各种席夫碱衍生物。合成的化合物在光谱研究(如紫外、红外和核磁共振)的基础上进行了表征。进一步筛选合成的衍生物对鼠伤寒沙门菌、索尼氏志贺氏菌、金黄色葡萄球菌和蜡样芽孢杆菌的抑菌效果。结果:希夫碱2-[(氨基苯基肼基)o,m，二硝基苯甲酰]苯胺(H)和化合物2-[(氨基苯基肼基)对氨基苯甲酰]苯胺(I)对几乎所有被试菌株都有很好的抑制区。结论:可以进一步尝试扩展该系列，探索其抗菌潜力，以达到预期的目的。

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Pharmaceutical and Biological Evaluations

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