Preliminary toxicity and gastroprotective potential of flavonoid-rich fractions of leaves from Opilia celtidifolia (Guill. & Perr.) Endl. ex Walp (Opiliaceae)

Konaté Kiessoun, D. I. Crepin, Diao Mamounata, Yomalan Kassi, A. Souza, M. Dicko
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Abstract

Objective : In Burkina Faso as in other developing countries, the diarrheal diseases constitute a serious problem of public health. To treat diarrhea, most Burkina Faso people living in the rural areas do rely on medicinal plants. To evaluate the traditional use of Opilia celtidifolia , scientific validation is needed. Methods : The collected plant materials were dried, pulverized, and aqueous acetone extracts were prepared. The serially diluted fractions of the extracts and finally reach the flavonoid-rich fractions which assayed for antibacterial activities against selected enteropathogens by agar well diffusion method, minimum inhibitory concentration and minimal bactericidal concentration respectively. The anti-diarrheal activity was evaluated using castor oil induced diarrhea, magnesium sulphate-induced diarrhea and gastrointestinal transit test examined in animal models respectively. Results : Flavonoid-rich fractions has positive effects in a dose dependent manner against diarrhoea induced by castor oil, magnesium sulphate-induced diarrhea and gastrointestinal transit test examined in animal models. The bioactive fraction also showed good antimicrobial activity against all bacteria strains and compared to the ciprofloxacin. Conclusions : These findings indicate that the flavonoid-rich fraction possesses antidiarrheal property in rats and confirm the ethnomedicinal use of Opilia celtidifolia a valuable natural remedy for the treatment, management and/or control of diarrhea. The results provided some insight into the gastroprotective potential of this plant traditionally used by the people of Burkina Faso to treat diarrhea.
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黄酮类化合物的初步毒性和胃保护作用。&穗青葱)。Endl。原蛇麻(蛇麻科)
目的:与其他发展中国家一样,腹泻病在布基纳法索构成了一个严重的公共卫生问题。为了治疗腹泻,大多数生活在农村地区的布基纳法索人确实依靠药用植物。要评价槐的传统用途,还需要科学的验证。方法:将采集的植物材料进行干燥、粉碎,制备丙酮水提物。通过琼脂孔扩散法、最小抑菌浓度法和最小杀菌浓度法对选定的肠道病原菌进行抑菌活性测定。采用蓖麻油致泻法、硫酸镁致泻法和动物胃肠运输法分别评价其抗泻活性。结果:富黄酮类成分对蓖麻油致腹泻、硫酸镁致腹泻及动物胃肠运输试验均有剂量依赖性的积极作用。与环丙沙星相比,生物活性部分对所有菌株均表现出良好的抑菌活性。结论:这些研究结果表明,黄酮类化合物在大鼠体内具有止泻作用,证实了蛇毛是一种治疗、管理和/或控制腹泻的宝贵天然药物。这些结果为这种植物的胃保护潜力提供了一些见解,这种植物传统上被布基纳法索人民用于治疗腹泻。
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