Nano Based Therapy for Biofilm Management: Mini Review

Abstract

High toxicity, low host tolerance, narrow spectrum of antifungal drugs and increasing incidence of azole-resistance complicates treatment of invasive Candida infections. Due to the emergence of antimicrobial resistance as an increasing threat to global health care, arises the need to develop new, and effective broad spectrum active antifungal agents. Thus understanding and combating drug resistance in Candida albicans is a toughest challenge being faced today and it’s immensely important to develop an alternative coating that can inhibit biofilm formation on medical devices as implants and catheters. Additionally, the fascinating properties of nanomaterials and biocompatibility promises great potential in nanomedical applications, especially in medical microbiology. With appropriate modification of these synthetic materials, several disease infections can be cured and results have shown the use of these nanomaterials as diagnostic and immunotherapauetic agents. Since, antimicrobial resistance is becoming a major apprehension worldwide, nanomedicines offer an intriguing and promising solution for combating these high resistance pathogens by appropriate development of therauptic and novel diagnosis approaches. This mini review presents the current state of art in this emerging field.