Correlation between Human Serum Immunoglobulin A and Complement Component receptor 1 (C5aR1) to Chronic Obstructive Pulmonary, Asthma and Tonsillitis Diseases

Haneen S. Albachary, S. Raisan, Ziyad Malgooth
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Abstract

Aim of the study: assess the level of immunoglobulin A, IgA, Complement protein C5a in Chronic Obstructive Pulmonary COPD, Asthmatic, and Tonsillitis patients.                       Material and methods: 98 samples were collected from patients aged (5 years old to older than 45 years) of different sexes, as well as samples, collected from 10 healthy people as control group in an immunological study. Serum concentration was done according to human IgA Bioassay Technology Laboratory Enzyme-Linked Immunosorbent Assay (ELISA) - Kits Cat.No E0189Hu and Complement Component C5a R1 Enzyme-Linked Immunosorbent Assay (ELISA) Kit   Cat. No. E6576Hu.                                                    Results: of the current study showed that the concentration of antibody A (IgA >20ng/ml) was higher in males by (62.5%) compared to females  and that the highest concentration was found in the age group greater than 45 by (31.8%) ) with a significant difference between the remaining age groups at the level of probability (p >  0.05) and  concentration of antibody A (IgA >20ng/ml) was high in all patients, and asthma constituted the highest percentage of increase in antibody A concentration by (32.65%) compared to the control samples with the presence of Significant difference at the level of probability (p > 0.05). the study also showed that Complement Component C5a R1 was high in all disease cases, and the increase was equal in percentage (6.8%) for the distribution of concentrations on patient samples with a significant difference between healthy and sick patients at the level of probability (p > 0.05) and it was high in males only with a percentage of (23.8 and that). The highest concentration was found in the two age groups (5-14and44-35) with a percentage of (6.8%) with no significant difference between the remaining age groups at the level of probability (p > 0.05). CONCLUSION:Asthma patients affected by the immune changes accompanying the disease compared to patients with Tonsillitis and COPD. High level of antibody concentration ,C5 in all diseased conditions, most affected by Asthmatic patients.
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人血清免疫球蛋白A和补体成分受体1 (C5aR1)与慢性阻塞性肺、哮喘和扁桃体炎疾病的相关性
研究目的:评估慢性阻塞性肺疾病(COPD)、哮喘和扁桃体炎患者的免疫球蛋白A、IgA、补体蛋白C5a水平。材料与方法:从不同性别(5岁至45岁以上)的患者中收集98份样本,并在免疫学研究中收集10名健康人作为对照组的样本。血清浓度按人IgA生物测定技术实验室酶联免疫吸附试验(ELISA) - kit Cat测定。No E0189Hu和补体组分C5a R1酶联免疫吸附测定(ELISA)试剂盒不。E6576Hu .                                                   结果:本研究结果显示,抗体A (IgA >0 ng/ml)浓度在男性中比女性高(62.5%),在大于45岁年龄组中浓度最高(31.8%),其余年龄组之间在概率水平上有显著差异(p > 0.05),抗体A (IgA >0 ng/ml)浓度在所有患者中均较高。与对照组相比,哮喘组抗体A浓度升高的比例最高(32.65%),在概率水平上存在显著性差异(p < 0.05)。本研究还表明,补体组分C5a R1在所有疾病病例中均较高,其在患者样本上的浓度分布增加的百分比相等(6.8%),在健康患者和患病患者之间的概率水平上有显著差异(p > 0.05),仅在男性中较高,百分比为(23.8%)。5-14岁和44-35岁年龄组的浓度最高,为6.8%,其余年龄组在概率水平上差异无统计学意义(p < 0.05)。结论:与扁桃体炎和慢性阻塞性肺病患者相比,哮喘患者伴发免疫改变。高水平的抗体浓度,C5在所有疾病,最受影响的哮喘患者。
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