{"title":"Free boundary problems for Stokes flow, with applications to the growth of biological tissues","authors":"John King, C. Venkataraman","doi":"10.4171/ifb/459","DOIUrl":null,"url":null,"abstract":"We formulate, analyse and numerically simulate what are arguably the two simplest Stokes-flow free boundary problems relevant to tissue growth, extending the classical Stokes free boundary problem by incorporating (i) a volumetric source (the nutrient-rich case) and (ii) a volumetric sink, a surface source and surface compression (the nutrient-poor case). Both two- and three-dimensional cases are considered. A number of phenomena are identified and characterised thereby, most notably a buckling-associated instability in case (ii).","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2021-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.4171/ifb/459","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
We formulate, analyse and numerically simulate what are arguably the two simplest Stokes-flow free boundary problems relevant to tissue growth, extending the classical Stokes free boundary problem by incorporating (i) a volumetric source (the nutrient-rich case) and (ii) a volumetric sink, a surface source and surface compression (the nutrient-poor case). Both two- and three-dimensional cases are considered. A number of phenomena are identified and characterised thereby, most notably a buckling-associated instability in case (ii).
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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