Quantitative Phytochemical Screening and In-vitro Antioxidant Activities of Jatropha gossypifolia L. Leaf Extracts Aiming Antimicrobial and Therapeutical Applications

Honoré Dezoumbe Donhai, Bayoï James Ronald, Darmand Roger Djoulde, Etoa François Xavier
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Abstract

Total phenolic (polyphenols, flavonoids, and condensed tannins) contents and antioxidant property (DPPH, ABTS, FRAP) were evaluated in hexane (HE), acetone (AC), ethanol (ET), 70% (v/v) ethanol/water (EW), and powder extracts of Jatropha gossypifolia leaves using spectrophotometric methods. The lowest and highest contents of polyphenols (10.27 ± 0.36 and 21.23 ± 0.95 mg GAE/g), flavonoids (4.83 ±0.42 and 12.53 ±0.58 mg QE/g), and condensed tannins (3.03 ± 0.18 and 7.13 ± 0.12 mg CE/g) were recorded in powder and EW, respectively. EW exhibited the highest scavenging activities displayed by the lowest IC50 values (0.23±0.01 mg/mL DPPH and 0.2±0.03 mg/mL ABTS). Moreover, it recorded the highest reducing power (92.85±1.25 mg AAE/g), followed by HE (72.73±1.99 mg AAE/g) and AC (41.84±0.47 mg AAE/g). Relevant correlations were found between the polyphenols, flavonoids, condensed tannins and reducing antioxidant power (r = 0.986, p < 0.01; r = 0.958, p < 0.01; r =0.950, p < 0.05; respectively). Based on their phytochemical and antioxidant properties, PCA classified the five extracts into three distinct clusters. The results of this study indicate that EW contains powerful bioactive molecules with noteworthy antiradical and electron donating properties. Therefore, it may be a promising candidate in the search for natural compounds with therapeutic and food/crop preservative applications.
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麻疯树叶提取物的体外抗氧化活性及其抗菌和治疗应用研究
采用分光光度法测定了麻桐叶的己烷(HE)、丙酮(AC)、乙醇(ET)、70% (v/v)乙醇/水(EW)和粉末提取物中总酚(多酚、类黄酮和缩合单宁)含量和抗氧化性能(DPPH、ABTS、FRAP)。黄酮类化合物(4.83±0.42和12.53±0.58 mg QE/g)和缩合单宁(3.03±0.18和7.13±0.12 mg CE/g)含量最低,分别为10.27±0.36和21.23±0.95 mg GAE/g。EW的IC50值最低(DPPH为0.23±0.01 mg/mL, ABTS为0.2±0.03 mg/mL),清除活性最高。其还原力最高(92.85±1.25 mg AAE/g),其次为HE(72.73±1.99 mg AAE/g)和AC(41.84±0.47 mg AAE/g)。多酚类、黄酮类、缩合单宁与还原性抗氧化能力呈显著相关(r = 0.986, p < 0.01;R = 0.958, p < 0.01;R =0.950, p < 0.05;分别)。根据其植物化学和抗氧化特性,PCA将五种提取物分为三个不同的簇。本研究结果表明,EW含有强大的生物活性分子,具有显著的抗自由基和供电子特性。因此,在寻找具有治疗和食品/作物防腐剂应用的天然化合物方面,它可能是一个有希望的候选者。
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来源期刊
CiteScore
1.00
自引率
12.50%
发文量
1
审稿时长
52 weeks
期刊介绍: Indian Journal of Natural Products and Resources (IJNPR), a quarterly journal, is dedicated to the exploration of topics that confront both educators, frontline workers in the fields, entrepreneurs and ultimate users of the value added products and their resources pertaining to both plants and animals. It publishes original research papers, reviews and short communications. The scope of the journal is multidisciplinary especially of applied nature. Papers on plant cultivation, fishery, apiary, poultry, dairy, disease and pest control measures, postharvest technology/practices, value added products and utilization of plants and animals in broader sense (including ethnobotany and pharmacology) are considered for publication.
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