{"title":"Anti-Tumor Activity of Oleanolic, Ursolic and Glycyrrhetinic Acid","authors":"Ju Feng, Wei Chen, Yu Zhao, Xiu-lian Ju","doi":"10.2174/1874848100902010048","DOIUrl":null,"url":null,"abstract":"Over last few years, there has been great interest on the anti-tumor properties of the triterpenoids, oleanolic, ur- solic and glycyrrhetinic acid in presence of many plants such as Olea europeae L., Actostaphylos uva-ursi and Glycyr- rhiza uralensis. The three acids and their derivatives show potential anti-tumor promoting and cytotoxic activities, inhibit- ing proliferation, inducing apotosis and preventing invasion, which suggested that they could be developed as anti-cancer and cancer chemopreventive agents. The mechanisms of the anti-tumor effects by triterpenoids need further investigation. A brief review is attempted here for their anti-tumor activities and chemical modification research.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2009-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"36","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Natural Products Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874848100902010048","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 36
Abstract
Over last few years, there has been great interest on the anti-tumor properties of the triterpenoids, oleanolic, ur- solic and glycyrrhetinic acid in presence of many plants such as Olea europeae L., Actostaphylos uva-ursi and Glycyr- rhiza uralensis. The three acids and their derivatives show potential anti-tumor promoting and cytotoxic activities, inhibit- ing proliferation, inducing apotosis and preventing invasion, which suggested that they could be developed as anti-cancer and cancer chemopreventive agents. The mechanisms of the anti-tumor effects by triterpenoids need further investigation. A brief review is attempted here for their anti-tumor activities and chemical modification research.