Pub Date : 2015-07-31DOI: 10.2174/1874848101508010001
Chunsriimyatav Ganbaatar, M. Gruner, Dumaa Mishig, Regdel Duger, Arndt W. Schmidt, H. Knölker
We describe the isolation, identification, and structural elucidation of natural products from the Mongolian me- dicinal plant Polygonatum odoratum (Mill.) Druce. Six flavonoid glycosides, isorhamnetin-3-O-rutinoside (narcissoside, narcissin) (1), kaempferol-3-O-rutinoside (nicotiflorin) (2), quercetin-3-O-rutinoside (rutin) (3), apigenin-6-C-� -D- glucoside (isovitexin) (4), apigenin-6-C-(2�� -O-� -D-xylopyranosyl-� -D-glucopyranoside) (desmodin) (5), and isovitexin-7- O-� -D-glucoside (saponarin) (6), were isolated from the aerial parts of Polygonatum odoratum (Mill.) Druce. The struc- tures of 1-6 have been confirmed by UV, IR, MS, and NMR ( 1 H, 13 C, COSY, HSQC, HMBC, NOESY, and ROESY) data. Graphical Abstract:
本文报道了蒙古药用植物黄精(Polygonatum odoratum)的分离、鉴定和结构分析。Druce。从黄精的地上部分中分离得到异鼠李苷-3-O-芦丁苷(水仙苷，水仙素)(1)、山奈酚-3-O-芦丁苷(烟花苷)(2)、槲皮素-3-O-芦丁苷(芦丁)(3)、芹菜素-6- c -(异牡荆素)(4)、芹菜素-6- c -(2 -O- - d -木吡喃甲酰基- - d -葡萄糖苷)(去皮苷)(5)和异牡荆素-7- O- - d -葡萄糖苷(皂苷)(6)6个类黄酮苷。Druce。通过紫外、红外、质谱和核磁共振(1h、13c、COSY、HSQC、HMBC、NOESY和ROESY)数据证实了1-6的结构。图形化的简介:
{"title":"Flavonoid Glycosides from the Aerial Parts of Polygonatum odoratum(Mill.) Druce Growing in Mongolia","authors":"Chunsriimyatav Ganbaatar, M. Gruner, Dumaa Mishig, Regdel Duger, Arndt W. Schmidt, H. Knölker","doi":"10.2174/1874848101508010001","DOIUrl":"https://doi.org/10.2174/1874848101508010001","url":null,"abstract":"We describe the isolation, identification, and structural elucidation of natural products from the Mongolian me- dicinal plant Polygonatum odoratum (Mill.) Druce. Six flavonoid glycosides, isorhamnetin-3-O-rutinoside (narcissoside, narcissin) (1), kaempferol-3-O-rutinoside (nicotiflorin) (2), quercetin-3-O-rutinoside (rutin) (3), apigenin-6-C-� -D- glucoside (isovitexin) (4), apigenin-6-C-(2�� -O-� -D-xylopyranosyl-� -D-glucopyranoside) (desmodin) (5), and isovitexin-7- O-� -D-glucoside (saponarin) (6), were isolated from the aerial parts of Polygonatum odoratum (Mill.) Druce. The struc- tures of 1-6 have been confirmed by UV, IR, MS, and NMR ( 1 H, 13 C, COSY, HSQC, HMBC, NOESY, and ROESY) data. Graphical Abstract:","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75610954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-09DOI: 10.2174/1874848101407010001
G. Brahmachari
The present resume covers an up-to-date literature on Limnophila species. The botanical classification, ethno- pharmacology, and chemical constituents of Limnophila plants, as well as the biological activities and pharmacological applications of both distinct phytochemicals and medicinally active plant materials (formulations, extracts, etc.) are dis- cussed in detail.
{"title":"Limnophila (Scrophulariaceae): Chemical and Pharmaceutical Aspects - An Update","authors":"G. Brahmachari","doi":"10.2174/1874848101407010001","DOIUrl":"https://doi.org/10.2174/1874848101407010001","url":null,"abstract":"The present resume covers an up-to-date literature on Limnophila species. The botanical classification, ethno- pharmacology, and chemical constituents of Limnophila plants, as well as the biological activities and pharmacological applications of both distinct phytochemicals and medicinally active plant materials (formulations, extracts, etc.) are dis- cussed in detail.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"22 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2015-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73706128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-11-01DOI: 10.2174/1874848101306010012
U. Kazmaier, Angelika Ullrich, J. Hoffmann
Tubulysins, linear tetrapeptides produced by several strains of myxobacteria, show an extremely high toxicity towards a wide range of cancer cell lines, with IC50 values in the nano or even picomolar range. Therefore, tubulysins and their derivatives might be suitable candidates for the development of antitumor drugs. Several synthetic approaches for tubulysins and derivates have been developed, which will be discussed in the review.
{"title":"Synthetic Approaches Towards Tubulysins and Derivatives Thereof","authors":"U. Kazmaier, Angelika Ullrich, J. Hoffmann","doi":"10.2174/1874848101306010012","DOIUrl":"https://doi.org/10.2174/1874848101306010012","url":null,"abstract":"Tubulysins, linear tetrapeptides produced by several strains of myxobacteria, show an extremely high toxicity towards a wide range of cancer cell lines, with IC50 values in the nano or even picomolar range. Therefore, tubulysins and their derivatives might be suitable candidates for the development of antitumor drugs. Several synthetic approaches for tubulysins and derivates have been developed, which will be discussed in the review.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"40 1","pages":"12-30"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79295654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-05-17DOI: 10.2174/1874848101306010005
S. Pacifico, B. D’Abrosca, M. Scognamiglio, M. Gallicchio, Silvia Galasso, P. Monaco, A. Fiorentino
The polyphenolic composition and antioxidant properties of the methanol leaf extract of Vitis × labruscana cv. 'Isabella' has been performed by means of different spectrophotometric antioxidant methods. Intracellular ROS produc- tion was measured by cell fluorescence after loading with 2',7'-H2DCF-DA. The extract promising efficacy has laid the basis to its phytochemical characterization. Three hydroxycinnamoyl tartaric acids (1-3), isoquercitrin 4, and five flavonol glycuronides (5-9) were isolated from Vitis × labruscana cv. 'Isabella' leaves. Chemical structures were elucidated on the basis of their spectroscopic features. Metabolites 6, 7, and 9, characterized by glucuronic or galacturonic acid methyl es- ter, are described from the genus Vitis for the first time. The metabolites isolated as major constituents were investigated for their DPPH radical scavenging capacity.
{"title":"Antioxidant Polyphenolic Constituents of Vitis × Labruscana cv. 'Isabella' Leaves","authors":"S. Pacifico, B. D’Abrosca, M. Scognamiglio, M. Gallicchio, Silvia Galasso, P. Monaco, A. Fiorentino","doi":"10.2174/1874848101306010005","DOIUrl":"https://doi.org/10.2174/1874848101306010005","url":null,"abstract":"The polyphenolic composition and antioxidant properties of the methanol leaf extract of Vitis × labruscana cv. 'Isabella' has been performed by means of different spectrophotometric antioxidant methods. Intracellular ROS produc- tion was measured by cell fluorescence after loading with 2',7'-H2DCF-DA. The extract promising efficacy has laid the basis to its phytochemical characterization. Three hydroxycinnamoyl tartaric acids (1-3), isoquercitrin 4, and five flavonol glycuronides (5-9) were isolated from Vitis × labruscana cv. 'Isabella' leaves. Chemical structures were elucidated on the basis of their spectroscopic features. Metabolites 6, 7, and 9, characterized by glucuronic or galacturonic acid methyl es- ter, are described from the genus Vitis for the first time. The metabolites isolated as major constituents were investigated for their DPPH radical scavenging capacity.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"6 1","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2013-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82180285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-04-05DOI: 10.2174/1874848101306010001
Binbing Ling, Qiulin Dong, Wanpeng Sun, D. Michel, R. Jiao, R. Sammynaiken, Yijiang Zhou, Jian Yang
Hedyotis diffusa has been used to treat cancers in traditional Chinese medicine for many years. Recently, sev- eral anthraquinone compounds were extracted from Hedyotis diffusa and identified as its anticancer ingredients. These compounds are able to induce apoptosis in several types of cancer cells. In this study, we showed that the anticancer activ- ity of Hedyotis diffusa was highly selective, possessing high cytotoxicity towards human breast cancer MCF7 cells but almost no cytotoxicity against the mammary epithelial MCF12A cells. The Hedyotis diffusa water extract also elevated the energy metabolism in both MCF12A and MCF7 cells; but the ATP/ADP ratio was still maintained at about 1.0 in the MCF12A cells to avoid either apoptosis or uncontrolled proliferation. In addition, Sheshecaojing, a health product of He- dyotis diffusa marketed in China, gave a dose-dependent cytotoxic response against the MCF7 cells.
{"title":"Evaluating the Anticancer Activity of Hedyotis diffusa Water Extract Against Human Breast Cancer MCF7 Cells","authors":"Binbing Ling, Qiulin Dong, Wanpeng Sun, D. Michel, R. Jiao, R. Sammynaiken, Yijiang Zhou, Jian Yang","doi":"10.2174/1874848101306010001","DOIUrl":"https://doi.org/10.2174/1874848101306010001","url":null,"abstract":"Hedyotis diffusa has been used to treat cancers in traditional Chinese medicine for many years. Recently, sev- eral anthraquinone compounds were extracted from Hedyotis diffusa and identified as its anticancer ingredients. These compounds are able to induce apoptosis in several types of cancer cells. In this study, we showed that the anticancer activ- ity of Hedyotis diffusa was highly selective, possessing high cytotoxicity towards human breast cancer MCF7 cells but almost no cytotoxicity against the mammary epithelial MCF12A cells. The Hedyotis diffusa water extract also elevated the energy metabolism in both MCF12A and MCF7 cells; but the ATP/ADP ratio was still maintained at about 1.0 in the MCF12A cells to avoid either apoptosis or uncontrolled proliferation. In addition, Sheshecaojing, a health product of He- dyotis diffusa marketed in China, gave a dose-dependent cytotoxic response against the MCF7 cells.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"03 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88904002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-11-16DOI: 10.2174/1874848101205010013
J. J. D. Adams, S. Tran, Vincent Wong, P. Fontaine, J. Petrosyan
Salvia columbariae extracts were examined for the presence of salvianolic acids by HPLC-MS and NMR. A new salvianolic acid, β-sitosterol lithospermic acid, was found.
{"title":"β-Sitosterol Lithospermate from Salvia Columbariae","authors":"J. J. D. Adams, S. Tran, Vincent Wong, P. Fontaine, J. Petrosyan","doi":"10.2174/1874848101205010013","DOIUrl":"https://doi.org/10.2174/1874848101205010013","url":null,"abstract":"Salvia columbariae extracts were examined for the presence of salvianolic acids by HPLC-MS and NMR. A new salvianolic acid, β-sitosterol lithospermic acid, was found.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"49 1","pages":"13-15"},"PeriodicalIF":0.0,"publicationDate":"2012-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88007508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-07-20DOI: 10.2174/1874848101205010007
R. Rumampuk, E. Pongoh, Ponis Tarigan, A. Herlt, L. Mander
The 1 H and 13 C NMR spectra of camelliagenin A and A1-barrigenol from the seeds of Barringtonia asiatica were completely assigned for the first time by one- and two-dimensional homo- and heteronuclear studies ( 1 H, 13 C, DQCOSY, TOCSY, HMQC, HMBC) at 600 and 150.89 MHz. The article reports standard data that may be important for potential authors needing such information.
利用1 H、13 C、DQCOSY、TOCSY、HMQC、HMBC在600和150.89 MHz下的一维和二维同质核和异核研究，首次对亚洲巴灵顿种子中茶茶花素A和A1-barrigenol的1 H和13 C NMR谱进行了完整的鉴定。本文报告的标准数据对于需要此类信息的潜在作者可能很重要。
{"title":"Complete Assignment of the 1H and 13C NMR Spectra of the Camelliagenin A and A1-Barrigenol from the seed of Barringtonia asiatica","authors":"R. Rumampuk, E. Pongoh, Ponis Tarigan, A. Herlt, L. Mander","doi":"10.2174/1874848101205010007","DOIUrl":"https://doi.org/10.2174/1874848101205010007","url":null,"abstract":"The 1 H and 13 C NMR spectra of camelliagenin A and A1-barrigenol from the seeds of Barringtonia asiatica were completely assigned for the first time by one- and two-dimensional homo- and heteronuclear studies ( 1 H, 13 C, DQCOSY, TOCSY, HMQC, HMBC) at 600 and 150.89 MHz. The article reports standard data that may be important for potential authors needing such information.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"36 1","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2012-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74725874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-05-28DOI: 10.2174/1874848101205010001
E. Borkowski, M. A. Álvarez, F. Suvire, R. Enriz
The experimental 13 C chemical shifts of five different series of organic compounds are compared with pre- dicted 13 C NMR chemical shifts obtained via empirically scaled GIAO shieldings. Our results indicate that the inclusion of a scaling factor allow to obtain an excellent correlation between δcalc and δexp. Although the inclusion of asymmetry im- proves this correlation, such enhancement was not observed for all the 54 tested compounds. We found RMS, a parameter related with the structural feature of the whole molecule, which could indicate the benefits of including asymmetry in these calculations.
{"title":"Correlation Between Experimental and DFT/GIAO Computed 13C NMR Chemical Shifts of Organic Compounds. Effects of Asymmetry","authors":"E. Borkowski, M. A. Álvarez, F. Suvire, R. Enriz","doi":"10.2174/1874848101205010001","DOIUrl":"https://doi.org/10.2174/1874848101205010001","url":null,"abstract":"The experimental 13 C chemical shifts of five different series of organic compounds are compared with pre- dicted 13 C NMR chemical shifts obtained via empirically scaled GIAO shieldings. Our results indicate that the inclusion of a scaling factor allow to obtain an excellent correlation between δcalc and δexp. Although the inclusion of asymmetry im- proves this correlation, such enhancement was not observed for all the 54 tested compounds. We found RMS, a parameter related with the structural feature of the whole molecule, which could indicate the benefits of including asymmetry in these calculations.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"52 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2012-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87223670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-02-07DOI: 10.2174/1874848101104010008
Emmanuel S. Akinboye, O. Bakare
Emetine is a natural product alkaloid from ipecac species. It is one of the main active ingredients in ipecac syrup used as emetic, and has been used extensively in phytomedicine as an antiparasitic drug. It inhibits both ribosomal and mitochondrial protein synthesis and interferes with the synthesis and activities of DNA and RNA. For this reason, it has been a vital tool to pharmacologists and has demonstrated many biological properties, such as antiviral, anticancer, antiparasitic and contraceptive activities. Also, it has been reported to cause the up-regulation and down-regulation of a number of genes. Some synthetic analogs with interesting biological activities have been prepared. This article reviews the biological activities of emetine and some emetine derived molecules.
{"title":"Biological Activities of Emetine","authors":"Emmanuel S. Akinboye, O. Bakare","doi":"10.2174/1874848101104010008","DOIUrl":"https://doi.org/10.2174/1874848101104010008","url":null,"abstract":"Emetine is a natural product alkaloid from ipecac species. It is one of the main active ingredients in ipecac syrup used as emetic, and has been used extensively in phytomedicine as an antiparasitic drug. It inhibits both ribosomal and mitochondrial protein synthesis and interferes with the synthesis and activities of DNA and RNA. For this reason, it has been a vital tool to pharmacologists and has demonstrated many biological properties, such as antiviral, anticancer, antiparasitic and contraceptive activities. Also, it has been reported to cause the up-regulation and down-regulation of a number of genes. Some synthetic analogs with interesting biological activities have been prepared. This article reviews the biological activities of emetine and some emetine derived molecules.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"58 1","pages":"8-15"},"PeriodicalIF":0.0,"publicationDate":"2011-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84049881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-02-04DOI: 10.2174/1874848101104010001
Samira Boutaleb-Charki, M. Sánchez-Moreno, Jesús Díaz, M. Rosales, Óscar Huertas, R. Gutiérrez-Sánchez, C. Marín
This study investigates the in vitro activity of a number of flavonoids (kaempferol, quercetin, trifolin, and ace- tyl hyperoside) and their acetylated products: kaempferol acetate, quercetin acetate, trifolin acetate, and acetyl hyperoside acetate) isolated from the aerial parts of plant Consolida oliveriana against epimastigote, amastigote and metacyclic forms of T. cruzi, their cytotoxic against a host Vero-cell line and analyse the possible mechanism by which these molecules act. Acetylated compounds were potent T. cruzi epimastigote growth inhibitors with activity levels similar to those of benzni- dazole, used as the reference drug. These compounds, at the dosage IC25, decreased the ability of metacyclic forms to in- vade mammalian cells, their intracellular replications and transformation in trypomastigotes, with no toxicity to the host cells. The cells treated presented severe damage in their ultrastructure: intense vacuolization, and appearance of lysosomes as well as other residual bodies. The mitochondrial section appeared larger in size, with a swollen matrix. In addition, these compounds changed the excretion of end metabolites, primarily affecting acetate and succinate excretion, possibly by directly influencing certain enzymes or their synthesis. The potent tripanocidal activities of the flavons described here represent an exciting advance in the search for new antiprotozoal agents.
{"title":"Activity and Mode of Action of Flavonoids Compounds Against Intracellular and Extracellular Forms of Trypanosoma cruzi","authors":"Samira Boutaleb-Charki, M. Sánchez-Moreno, Jesús Díaz, M. Rosales, Óscar Huertas, R. Gutiérrez-Sánchez, C. Marín","doi":"10.2174/1874848101104010001","DOIUrl":"https://doi.org/10.2174/1874848101104010001","url":null,"abstract":"This study investigates the in vitro activity of a number of flavonoids (kaempferol, quercetin, trifolin, and ace- tyl hyperoside) and their acetylated products: kaempferol acetate, quercetin acetate, trifolin acetate, and acetyl hyperoside acetate) isolated from the aerial parts of plant Consolida oliveriana against epimastigote, amastigote and metacyclic forms of T. cruzi, their cytotoxic against a host Vero-cell line and analyse the possible mechanism by which these molecules act. Acetylated compounds were potent T. cruzi epimastigote growth inhibitors with activity levels similar to those of benzni- dazole, used as the reference drug. These compounds, at the dosage IC25, decreased the ability of metacyclic forms to in- vade mammalian cells, their intracellular replications and transformation in trypomastigotes, with no toxicity to the host cells. The cells treated presented severe damage in their ultrastructure: intense vacuolization, and appearance of lysosomes as well as other residual bodies. The mitochondrial section appeared larger in size, with a swollen matrix. In addition, these compounds changed the excretion of end metabolites, primarily affecting acetate and succinate excretion, possibly by directly influencing certain enzymes or their synthesis. The potent tripanocidal activities of the flavons described here represent an exciting advance in the search for new antiprotozoal agents.","PeriodicalId":22871,"journal":{"name":"The Open Natural Products Journal","volume":"17 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2011-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80979338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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