Effectiveness of Vitamin C Consumption In Pregnancy On Dexamethasone Induced Low Birth Weight.

Ls Ojular, A. Olatinwo, O. Adegoke
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Abstract

Synthet ic glucocor t icoids, including Dexamethasone have been shown to induce Intra Uterine Growth Retardat ion (IUGR) when administered in the last trimester of pregnancy. This study was designed to investigate the effect of Vitamin C on Dexamethasone induced low birth weight an experimental model using theAlbino rats. Pregnant Sprague Dawley rats were divided into four groups of six rats each; group A- vehicle only, group B- Vitamin C treated (100mg/kg maternal body weight), group C-Dexamethasone treated (bolus dose of 100 micro grams of Dexamethasone/kg maternal body weight on day 13 followed by a daily dose of 200 micro grams/kg maternal body weight from day 14 till delivery) and group D -Dexamethasone and Vitamin C treated (100mg/kg maternal body weight of Vitamin C from day 7 of pregnancy to term; and on day 13 of pregnancy, were injected with a bolus dose of 100 micro grams/kg maternal body weight of Dexamethasone and subsequently a daily dose of 200 micro grams/kg maternal body weight until term). The weight and size of the litters along with the gestation period and weight gain during the period of study were recorded. T h e r e s u l t s s h owe d t h a t t h o u g h Dexamethasone caused low birth weight, Vitamin C had no significant (p>0.05) effect on dexamethasone induced low birth weight, litter size or gestation period. It was hereby concluded that this was probably due to the inability of Vitamin C to influence the mechanisms by which dexamethasone induces low birth weight.
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妊娠期维生素C摄入对地塞米松所致低出生体重的影响。
合成糖皮质激素,包括地塞米松,已被证明可诱导子宫内生长迟缓(IUGR),当使用在妊娠的最后三个月。本研究旨在探讨维生素C对地塞米松诱导的白化病大鼠低出生体重的影响。将怀孕的Sprague Dawley大鼠分为四组,每组6只;A组-纯车辆组,B组-维生素C组(100mg/kg产妇体重),C组-地塞米松组(第13天给药100微克地塞米松/kg产妇体重,从第14天到分娩,每天给药200微克/kg产妇体重),D组-地塞米松和维生素C组(从妊娠第7天至足月,100mg/kg产妇体重的维生素C);在妊娠第13天,注射100微克/千克母体体重的地塞米松,随后每日注射200微克/千克母体体重的地塞米松,直至足月。记录研究期间窝鼠的体重、大小、妊娠期及增重情况。而维生素C对地塞米松所致低出生体重、产仔数和妊娠期的影响均不显著(p>0.05)。由此得出结论,这可能是由于维生素C无法影响地塞米松诱导低出生体重的机制。
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