INDICATORS OF THE RAT CARDIORESPIRATORY SYSTEM UNDER THE ACTION OF ACETYLSALICYLIC ACID AND ITS COMPLEX COMPOUNDS WITH METALS

Abstract

The paper researches the effect of cobalt (АСCo2+) and zinc (АСZn2+), nickel (Ni2+) and manganese (Mn2+) acetylsalicylates in doses of 5 and 10 mg/kg on the characteristics of the rats’ cardiorespiratory system. The study was carried out on the basis of the Center for collective use of scientific equipment «Experimental Physiology and Biophysics» of the Department of Human and Animal Physiology and Biophysics of the V. I. Vernadsky Crimean Federal University. The research of the biological effect of the acetylsalicylic acid, АСCo2+, АСZn2+ , АСNi2+, АСMn2+was carried out during their intraperitoneal injection into rats in doses of 5 mg/kg and 10 mg/kg. Simultaneously the following characteristics of all the groups’ animals were registered: heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP) and diastolic blood pressure (DBP). The pulse pressure (PP) was calculated on the basis of the SBP and DBP indices difference. BP, HR and RR of the rats were registered with the help of the system NIBP200A («BiopacSystems, Inc.», USA). The results of the current research allowed to determine that the coordinating compounds of the acetylsalicylic acid with such metals as Co, Zn, Ni2+, Mn2+ not only have more pronounced biological effect in comparison with the acetylsalicylic acid, but demonstrate new properties; the most effect on the cardiorespiratory system was achieved by АСZn2+. Thus, the results of the current research allow us to claim that the salts of the acetylsalicylates, having the metal-complexing in its molecules’ composition, have more pronounced and qualitatively new properties in comparison with the acetylsalicylic acid precursor’s properties; this makes the further search for biological and pharmaceutical activity of these coordinating compounds more perspective, as well as it makes the technology of complexingan inexpensive and highly efficient approach to the creation of new medicines. The reported study was funded by RFBR, project number 20-33-70142