Antimicrobial susceptibility pattern of pathogens from urinary isolates of diabetic patients in a tertiary care hospital in South Tamil Nadu

Abstract

Since diabetes has several negative effects on the urinary tract and host immune system, urinary tract infections (UTIs) pose a serious health issue for diabetic people. The majority of individuals with defective genitourinary tracts get complicated UTIs. To avoid morbidity and significant life-threatening conditions linked to co-morbid diabetes and UTIs, quick diagnosis and treatment are required. Effective care of these patient groups will be facilitated by knowledge of the many bacterial agents that cause UTI in diabetes patients and non-diabetic patients, as well as their susceptibility profiles.: This cross sectional study, which was conducted in a tertiary care hospital Virudhunagar, South Tamil Nadu, is aimed to compare the prevalence of UTI, the causative bacteria, and their antibiotic susceptibility profiles in diabetic patients (168) and non- diabetics (150). The existence of urinary tract bacterial pathogens was determined by microbiologic analysis of a urine sample that was collected aseptically. The Kirby Bauer technique was used to screen the isolates for drug susceptibility in order to determine their patterns of antibiotic resistance.: Urinary tract bacterial infections were found in 37.5% and 36.6% of samples from diabetes and non-diabetic people, respectively. species, , and () were the organisms present in the urine samples in the following proportions for the diabetic and non-diabetic individuals, respectively: 34.92% and 29.09%, 12.69% and 10.9%, 7.93% and 12, 6.34% and 5.45%, 3.17% and 1.81%, 3.17% and 0, 22.2% and 16.36%, 9.52% and 14.54% and 0 and 9.09%. Nevertheless, the difference in the percentages of isolated bacteria was not statistically significant (-value = 0. 856). The majority of the antibiotics tested on bacteria isolated from diabetic and non-diabetic people were extremely effective, particularly Meropenem, Amikacin, Gentamicin, Piperacillin – tazobactam and Nitrofurantoin for gram negative bacteria and Vancomycin and Amikacin for gram - positive bacteria.: The current study's findings highlight the necessity of doing sensitivity testing before beginning antibiotic therapy for UTI since they might aid in the right selection of antibiotics, ensure that they are used effectively, and thus avoid antibiotic resistance.