CORR Insights®: Is Delayed Time to Surgery Associated with Increased Short-term Complications in Patients with Pathologic Hip Fractures?

M. Ghert
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Abstract

Because so many patients with cancer now are living longer as a result of targeted systemic therapies [4], skeletal metastases [7] and the pathological fractures they cause—especially to the hip—should force us to focus on how to improve the care of patients with this problem. In the current study, Varady and colleagues [18] do exactly this; they found that taking the time to medically prepare such complex patients for surgery does not compromise their postoperative outcomes in terms of surgical complications and perioperative mortality. This may be different than what we (think we) know about patients with osteoporotic hip fractures; studies suggest that delayed surgery in those patients is associated with a greater risk of complications and death [11], but whether that delay causes the excess complications remains controversial. However, what is most striking is that Varady and colleagues [18] have shown that the presence of disseminated disease is associated with increased morbidity and mortality. In other words, patients with disseminated disease are high-risk surgical fixation patients and prophylactic fixation is likely to be safer for them. Although one can say this is intuitive, it does bring to light the imperative of identifying patients at risk for fracture, as surgery is safer for those undergoing prophylactic fixation compared to undergoing fixation after a fracture has occurred [15]. Based on this, healthcare systems can introduce policies that prioritize patients with cancer and disseminated disease into screening programs to identify fractures before they occur.
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CORR Insights®:延迟手术时间与病理性髋部骨折患者短期并发症增加有关吗?
由于现在有如此多的癌症患者由于靶向全身治疗而延长了寿命[4],骨骼转移[7]及其引起的病理性骨折-特别是髋关节-应该迫使我们关注如何改善对患有这一问题的患者的护理。在目前的研究中,Varady及其同事[18]正是这样做的;他们发现,从手术并发症和围手术期死亡率方面来看,花时间为如此复杂的患者做手术的医学准备并不会影响他们的术后结果。这可能与我们(自认为)对骨质疏松性髋部骨折患者的了解不同;研究表明,这些患者的延迟手术与更大的并发症和死亡风险相关[11],但延迟是否导致了过多的并发症仍存在争议。然而,最引人注目的是Varady和他的同事[18]表明,播散性疾病的存在与发病率和死亡率的增加有关。换句话说,弥散性疾病患者是手术固定的高危患者,预防性固定可能对他们更安全。虽然可以说这是直观的,但它确实揭示了识别有骨折风险的患者的必要性,因为对于那些进行预防性固定的患者来说,手术比在骨折发生后进行固定更安全[15]。基于此,医疗保健系统可以引入政策,将患有癌症和播散性疾病的患者优先纳入筛查计划,以便在骨折发生之前识别骨折。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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