Type 2 diabetes mellitus and severe periodontal disease in an adult population; effect of a new local delivery approach

Mahmoud Helmy Belal, Abdulaziz Yassin
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Abstract

Objective: The aim of this study is to clarify association between diabetes mellitus and periodontitis, and assess the effect of metronidazole and chlorhexidine mixture as a local delivery. Methods: Sixty patients constituted three groups: (I) type 2 diabetes with advanced periodontitis; (II) diabetes mellitus without periodontitis; and (III) periodontitis without diabetes. Clinical attachment loss (CAL) and bleeding index (BI) were recorded. Periodontitis received first non-surgical therapy, and then metronidazole and chlorhexidine gel. Diabetics undertook blood analysis for diabetic factors. Results: Statistical differences were noticed between groups I and II at all periods (three and six month) except few sites, and between groups I and III at all sites of CAL and most sites of BI. Group I had the worst measurements at baseline and 3 month which reversed with less measurements at 6 month (following therapy) by demonstrating significant intergroup positive changes, without significance prior to therapy. No significant differences were noticed within groups I and III for CAL prior to therapy except few sites, but were present at 6 month at all sites in group III and except two sites in group I. For BI, no differences were noticed except three sites. Conclusion: The present study suggested evidence on improvement of periodontal parameters following treatment with the local mixture of metronidazole and chlorhexidine gel.
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成人2型糖尿病和严重牙周病的研究一种新的本地交付方式的效果
目的:探讨糖尿病与牙周炎的关系,评价甲硝唑和氯己定合剂局部给药的效果。方法:60例患者分为3组:(1)2型糖尿病合并晚期牙周炎;(二)糖尿病伴牙周炎者;(三)无糖尿病的牙周炎。记录临床附着丧失(CAL)和出血指数(BI)。牙周炎先予非手术治疗,后予甲硝唑和氯己定凝胶治疗。糖尿病患者对糖尿病因素进行血液分析。结果:除少数部位外,I组和II组在所有时期(3个月和6个月)均有统计学差异,I组和III组在CAL的所有部位和BI的大部分部位均有统计学差异。第一组在基线和3个月时测量值最差,在治疗后6个月测量值减少,显示出显著的组间阳性变化,治疗前无显著性变化。在治疗前,除了少数几个部位外,I组和III组之间的CAL没有显著差异,但在6个月时,除了I组的两个部位外,III组的所有部位都存在差异。对于BI,除了三个部位外,没有注意到差异。结论:甲硝唑与氯己定凝胶局部混合治疗可改善牙周参数。
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