首页 > 最新文献

Journal of Experimental and Integrative Medicine最新文献

英文 中文
A comparative study of polyherbal Unani formulations in gestational Urinary tract infections 复方乌纳尼治疗妊娠期尿路感染的比较研究
Pub Date : 2017-01-01 DOI: 10.5455/JEIM.290117.OR.166
Azra Nishat, Shazadi Sultana, A. Sultana
Introduction: To compare the efficacy of two polyherbal Unani formulations in gestational urinary tract infections (GUTIs). Materials and Methods: A prospective, randomized, comparative trial was conducted at Nizamia Tibbia College. Group A (n = 20) received mucilage of Althaea officinalis L. (5 ml) with 2.5 g powder of Sphaeranthus indicus L., Euphorbia hypericifolia L., Tribulus terrestris L., and Sharbat Anar shireen (Punica granatum) 10 ml, whereas Group B (n = 20) received 2.5 g powder of Citrullus vulgaris seeds L., Cucumis melo L. seed, and S. indicus L. orally twice daily after meals for 3 consecutive months. The primary outcome included cured measured as negative urine culture and alleviation of GUTIs symptoms. The secondary outcomes included the absence of pus cell in urine analysis, Apgar score, prevention of complication of GUTIs, and perinatal outcome. The results were analyzed with chi-square, Fisher exact test and student t-test with alpha 0.05. Results: The cure rate in Groups A and B was similar with 50% response. Both groups were equally effective in relieving the GUTIs symptoms (P < 0.001), Apgar score was >7, good perinatal outcome with no preterm labor, and intrauterine growth retardation. No maternal and fetal adverse effects were noted. Conclusion: Both groups were equally effective for the treatment of GUTIs without any maternal and fetal adverse effects.
前言:比较两种复方乌纳尼治疗妊娠期尿路感染的疗效。材料和方法:在Nizamia Tibbia学院进行了一项前瞻性、随机、比较试验。A组(n = 20)给予药用杜鹃花黏液(5 ml)和黄球、大胡麻、蒺藜、刺蒺藜粉(10 ml), B组(n = 20)给予瓜籽、甜瓜籽、刺蒺藜粉(2.5 g),每日2次,饭后口服,连续3个月。主要结局包括尿培养阴性的治愈和GUTIs症状的缓解。次要结局包括尿分析中脓细胞的缺失、Apgar评分、GUTIs并发症的预防和围产期结局。结果采用卡方检验、Fisher精确检验和学生t检验,alpha 0.05。结果:A组和B组治愈率相近,有效率均为50%。两组在缓解GUTIs症状方面同样有效(P < 0.001), Apgar评分>7,围产期结局良好,无早产,无宫内生长迟缓。没有发现母体和胎儿的不良反应。结论:两组治疗GUTIs的疗效相同,无母婴不良反应。
{"title":"A comparative study of polyherbal Unani formulations in gestational Urinary tract infections","authors":"Azra Nishat, Shazadi Sultana, A. Sultana","doi":"10.5455/JEIM.290117.OR.166","DOIUrl":"https://doi.org/10.5455/JEIM.290117.OR.166","url":null,"abstract":"Introduction: To compare the efficacy of two polyherbal Unani formulations in gestational urinary tract infections (GUTIs). Materials and Methods: A prospective, randomized, comparative trial was conducted at Nizamia Tibbia College. Group A (n = 20) received mucilage of Althaea officinalis L. (5 ml) with 2.5 g powder of Sphaeranthus indicus L., Euphorbia hypericifolia L., Tribulus terrestris L., and Sharbat Anar shireen (Punica granatum) 10 ml, whereas Group B (n = 20) received 2.5 g powder of Citrullus vulgaris seeds L., Cucumis melo L. seed, and S. indicus L. orally twice daily after meals for 3 consecutive months. The primary outcome included cured measured as negative urine culture and alleviation of GUTIs symptoms. The secondary outcomes included the absence of pus cell in urine analysis, Apgar score, prevention of complication of GUTIs, and perinatal outcome. The results were analyzed with chi-square, Fisher exact test and student t-test with alpha 0.05. Results: The cure rate in Groups A and B was similar with 50% response. Both groups were equally effective in relieving the GUTIs symptoms (P < 0.001), Apgar score was >7, good perinatal outcome with no preterm labor, and intrauterine growth retardation. No maternal and fetal adverse effects were noted. Conclusion: Both groups were equally effective for the treatment of GUTIs without any maternal and fetal adverse effects.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"3 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82424042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Isolated plexiform neurofibroma in a patient with Tuberous Sclerosis-a rare association - 结节性硬化症患者的孤立丛状神经纤维瘤-罕见的关联
Pub Date : 2017-01-01 DOI: 10.5455/JEIM.080317.CR.008
Joyeeta Chowdhury, Loknath Ghoshal, Subhomay Neogi
Plexiform neurofibroma is a rare tumour originating in peripheral nerve sheaths. It is mostly associated with Neurofibromatosis type1 and occasionally as an isolated entity. We report a case of isolated plexiform neurofibroma associated with Tuberous sclerosis.
摘要丛状神经纤维瘤是一种起源于周围神经鞘的罕见肿瘤。它主要与1型神经纤维瘤病有关,偶尔作为一个孤立的实体。我们报告一例孤立的丛状神经纤维瘤合并结节性硬化症。
{"title":"Isolated plexiform neurofibroma in a patient with Tuberous Sclerosis-a rare association -","authors":"Joyeeta Chowdhury, Loknath Ghoshal, Subhomay Neogi","doi":"10.5455/JEIM.080317.CR.008","DOIUrl":"https://doi.org/10.5455/JEIM.080317.CR.008","url":null,"abstract":"Plexiform neurofibroma is a rare tumour originating in peripheral nerve sheaths. It is mostly associated with Neurofibromatosis type1 and occasionally as an isolated entity. We report a case of isolated plexiform neurofibroma associated with Tuberous sclerosis.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"17 1","pages":"11-12"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84384484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation clinical, electrocardiographic and laboratory response of reperfusion therapy in patients with first acute myocardial infarction 评价首次急性心肌梗死患者再灌注治疗的临床、心电图和实验室反应
Pub Date : 2017-01-01 DOI: 10.5455/jeim.130217.or.167
B. Zamani, Manouchehr IranparvarAlamdari, M. Ashrafi
Myocardial infarction (MI) is one of the most common causes of death and disability in various societies, especially in developed countries, and its complications are one of the main health problems in each country, especially in the big cities and among middle-aged and adult people [1,2]. Acute MI (AMI), which is the most common cause of acute attacks, is often caused due to obstructive coronary artery due to a blood clot, severe spasm of the arteries or atherosclerosis in the coronary arteries. In recent decades, despite of improving public health condition in many countries of the world, the incidence of cardiovascular diseases has become the most important health problem [1-3]. Returning of ST-segment is a good predictor of infarct artery patency and preserves myocardial perfusion in heart tissue level [4,5]. The successful resolution in ST-segment is as an electrocardiographic (ECG) signal of myocardial tissue repair which indicates the progression of infarction [6]. If the primary percutaneous coronary intervention (PCI) is not available, one of the initial treatment of AMI is the prescription of thrombolytic medication, which is considered the primary and preferred method of lifesaving [2,3]. Among thrombolytic medications, streptokinase (SK) due to the opening of the blocked artery by thrombosis and reduction of mortality without any potential hemorrhagic complications is more important [7-9]. Quick start of SK and other thrombolytic medications leads to adjacent of ischemic myocardial perfusion to the infarct region. The success of thrombolysis in clot lysis and creating second reperfusion in saving myocardial ischemic and in preserving of myocardial function plays a key role [8]. The effect of thrombolytic medications in creating myocardial perfusion can be measured by several factors, and angiography is considered as a delayed and invasive method in approaching the patients who received thrombolytic medications.
心肌梗死(MI)是各个社会,尤其是发达国家最常见的死亡和残疾原因之一,其并发症是每个国家,尤其是大城市和中年人和成年人的主要健康问题之一[1,2]。急性心肌梗死(AMI)是急性发作最常见的原因,通常是由于血凝块、动脉严重痉挛或冠状动脉粥样硬化导致冠状动脉梗阻性。近几十年来,尽管世界上许多国家的公共卫生状况有所改善,但心血管疾病的发病率已成为最重要的健康问题[1-3]。st段返回是梗死动脉通畅的良好预测指标,并能在心脏组织水平上保持心肌灌注[4,5]。st段的成功分解作为心肌组织修复的心电图信号,提示梗死的进展[6]。如果没有经皮冠状动脉介入治疗(PCI), AMI的初始治疗方法之一是开溶栓药物,这被认为是主要和首选的救命方法[2,3]。在溶栓药物中,链激酶(SK)由于血栓形成而使阻塞的动脉打开,降低死亡率而没有任何潜在的出血并发症是更重要的[7-9]。SK等溶栓药物的快速启动导致缺血心肌灌注与梗死区相邻。溶栓成功进行凝块溶解和二次再灌注对挽救心肌缺血和保存心肌功能具有关键作用[8]。溶栓药物对心肌灌注的影响可以通过几个因素来衡量,血管造影被认为是一种延迟和侵入性的方法来接近接受溶栓药物治疗的患者。
{"title":"Evaluation clinical, electrocardiographic and laboratory response of reperfusion therapy in patients with first acute myocardial infarction","authors":"B. Zamani, Manouchehr IranparvarAlamdari, M. Ashrafi","doi":"10.5455/jeim.130217.or.167","DOIUrl":"https://doi.org/10.5455/jeim.130217.or.167","url":null,"abstract":"Myocardial infarction (MI) is one of the most common causes of death and disability in various societies, especially in developed countries, and its complications are one of the main health problems in each country, especially in the big cities and among middle-aged and adult people [1,2]. Acute MI (AMI), which is the most common cause of acute attacks, is often caused due to obstructive coronary artery due to a blood clot, severe spasm of the arteries or atherosclerosis in the coronary arteries. In recent decades, despite of improving public health condition in many countries of the world, the incidence of cardiovascular diseases has become the most important health problem [1-3]. Returning of ST-segment is a good predictor of infarct artery patency and preserves myocardial perfusion in heart tissue level [4,5]. The successful resolution in ST-segment is as an electrocardiographic (ECG) signal of myocardial tissue repair which indicates the progression of infarction [6]. If the primary percutaneous coronary intervention (PCI) is not available, one of the initial treatment of AMI is the prescription of thrombolytic medication, which is considered the primary and preferred method of lifesaving [2,3]. Among thrombolytic medications, streptokinase (SK) due to the opening of the blocked artery by thrombosis and reduction of mortality without any potential hemorrhagic complications is more important [7-9]. Quick start of SK and other thrombolytic medications leads to adjacent of ischemic myocardial perfusion to the infarct region. The success of thrombolysis in clot lysis and creating second reperfusion in saving myocardial ischemic and in preserving of myocardial function plays a key role [8]. The effect of thrombolytic medications in creating myocardial perfusion can be measured by several factors, and angiography is considered as a delayed and invasive method in approaching the patients who received thrombolytic medications.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"31 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89978249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro anthelmintic activity of aqueous extract of Crassocephalum crepidioides (Benth.) S. Moore on Haemonchus contortus. 粗头草水提物体外驱虫活性的研究S.摩尔论弯曲血蜱。
Pub Date : 2016-08-04 DOI: 10.5455/JEIM.061215.OR.144
C. Z. Bogning, Abiodoun Pascal Oloulade, G. G. Alowanou, E. L. Nguemfo, A. Azébazé, A. Dongmo, S. Hounzangbé-Adoté
Objectives: Gastrointestinal parasites are recognized as major constraint to livestock production throughout the tropics. The use of plants and plant extracts remain the most serious alternative to modern anthelmintic drugs. This study evaluates the in vitro anthelmintic activity of aqueous leaves extract of Crassocephalum crepidioides against Haemonchus contortus. Methods: Aqueous extract at concentrations of 75 to 2400 µg/ml was tested in vitro on three development stages of H. contortus using egg hatch assay (EHA), larval migration inhibition assay (LMIA) and adult worms motility inhibition assay (AMIA). Results: EHA showed significant reduction (P < 0.05) on H. contortus egg hatch. The inhibition of egg hatching was concentration dependent with the greatest inhibition (50.52%) at the highest concentration (2400 µg/ml) of the extract. Thiabendazole used as positive control showed significant inhibition (P < 0.001) with rate of 76.68 % at the highest concentration (500µg/ml). On LMIA the extract significantly (P < 0.05) inhibited larval migration of L3 in a concentration dependent manner compared to Phosphate Buffered Saline, but less than levamisole (P < 0.001). The highest inhibition rate was 35.30 % at the concentration of 1200 µg/ml. The addition of polyvinylpolyrrolidone to the aqueous extract slightly reduces (4.9%) the inhibition of the effect induced by the extract on larval migration. Effect of extract on AMIA was concentration-dependent with significant increase (P < 0.05) in percentage of inhibition after 12 h. Levamisole (500 µg/ml) kills 100% worms after 18 h post-exposure but by this time the plant exhibited only 16.67% inhibition at the highest concentration (2400 µg/ml). Conclusion: These finding indicate that C. crepidioides leaves have anthelmintic properties against H. contortus. This activity may be due to secondary metabolites such as saponins, flavonoids and tannins present in the extract. Further studies are needed to evaluate deeply the anthelmintic potential of this plant.
目的:胃肠道寄生虫被认为是整个热带地区牲畜生产的主要制约因素。使用植物和植物提取物仍然是现代驱虫药最严重的替代品。本研究评价了白草叶水提物对弯血螨的体外驱虫活性。方法:采用卵孵化法(EHA)、幼虫迁移抑制法(LMIA)和成虫运动抑制法(AMIA),对75 ~ 2400µg/ml的水提物在3个发育阶段进行体外实验。结果:EHA水平显著降低(P < 0.05)。对虫卵孵化的抑制呈浓度依赖性,在最高浓度(2400µg/ml)时,对虫卵孵化的抑制作用最大,为50.52%。以噻苯达唑为阳性对照,在最高浓度(500µg/ml)下,抑制率为76.68% (P < 0.001)。与磷酸盐缓冲盐水相比,LMIA提取物显著(P < 0.05)抑制L3幼虫的迁移,且呈浓度依赖性,但低于左旋咪唑(P < 0.001)。当浓度为1200µg/ml时,抑制率最高,为35.30%。在水提液中加入聚乙烯聚咯烷酮后,对幼虫迁移的抑制作用略有降低(4.9%)。提取物对AMIA的抑制作用呈浓度依赖性,12 h后抑制率显著增加(P < 0.05)。左旋咪唑(500µg/ml)在18 h后杀死100%的蠕虫,但此时最高浓度(2400µg/ml)的抑制率仅为16.67%。结论:这些结果表明,蛇皮草叶片具有驱虫作用。这种活性可能是由于次生代谢物,如皂苷,黄酮类化合物和单宁存在于提取物。需要进一步的研究来深入评价该植物的驱虫潜力。
{"title":"In vitro anthelmintic activity of aqueous extract of Crassocephalum crepidioides (Benth.) S. Moore on Haemonchus contortus.","authors":"C. Z. Bogning, Abiodoun Pascal Oloulade, G. G. Alowanou, E. L. Nguemfo, A. Azébazé, A. Dongmo, S. Hounzangbé-Adoté","doi":"10.5455/JEIM.061215.OR.144","DOIUrl":"https://doi.org/10.5455/JEIM.061215.OR.144","url":null,"abstract":"Objectives: Gastrointestinal parasites are recognized as major constraint to livestock production throughout the tropics. The use of plants and plant extracts remain the most serious alternative to modern anthelmintic drugs. This study evaluates the in vitro anthelmintic activity of aqueous leaves extract of Crassocephalum crepidioides against Haemonchus contortus. \u0000Methods: Aqueous extract at concentrations of 75 to 2400 µg/ml was tested in vitro on three development stages of H. contortus using egg hatch assay (EHA), larval migration inhibition assay (LMIA) and adult worms motility inhibition assay (AMIA). \u0000Results: EHA showed significant reduction (P < 0.05) on H. contortus egg hatch. The inhibition of egg hatching was concentration dependent with the greatest inhibition (50.52%) at the highest concentration (2400 µg/ml) of the extract. Thiabendazole used as positive control showed significant inhibition (P < 0.001) with rate of 76.68 % at the highest concentration (500µg/ml). On LMIA the extract significantly (P < 0.05) inhibited larval migration of L3 in a concentration dependent manner compared to Phosphate Buffered Saline, but less than levamisole (P < 0.001). The highest inhibition rate was 35.30 % at the concentration of 1200 µg/ml. The addition of polyvinylpolyrrolidone to the aqueous extract slightly reduces (4.9%) the inhibition of the effect induced by the extract on larval migration. Effect of extract on AMIA was concentration-dependent with significant increase (P < 0.05) in percentage of inhibition after 12 h. Levamisole (500 µg/ml) kills 100% worms after 18 h post-exposure but by this time the plant exhibited only 16.67% inhibition at the highest concentration (2400 µg/ml). \u0000Conclusion: These finding indicate that C. crepidioides leaves have anthelmintic properties against H. contortus. This activity may be due to secondary metabolites such as saponins, flavonoids and tannins present in the extract. Further studies are needed to evaluate deeply the anthelmintic potential of this plant.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"6 1","pages":"31-37"},"PeriodicalIF":0.0,"publicationDate":"2016-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80185681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
(D-Ser2)Oxm[Lys38-γ-glu-PAL] improves hippocampal gene expression and cognition in a mouse model of type 1 diabetes - (D-Ser2)Oxm[Lys38-γ-glu- pal]改善1型糖尿病小鼠模型海马基因表达和认知
Pub Date : 2016-03-31 DOI: 10.5455/JEIM.050216.BR.027
N. Pathak, N. Irwin, V. Pathak, V. Gault, P. Flatt
Objective: Oxyntomodulin (Oxm) is a gastrointestinal hormone with recently noted therapeutic potential for type 1 diabetes mellitus (T1DM). The present study examined the effects of a stable Oxm analogue on anxiety, exploratory behavior, cognitive function, hippocampal gene expression and metabolic control in a mouse model of T1DM. Materials and Methods: Effects of twice daily administration of the stable Oxm analogue, (D-Ser2)Oxm[Lys38-γ-glu-PAL], was assessed in insulin-deficient streptozotocin (STZ)-induced T1DM mice. Results: Induction of diabetes by STZ injection significantly (P < 0.05) impaired learning and memory compared to normal control mice. However, (D-Ser2)Oxm[Lys38-γ-glu-PAL] treatment completely reversed this detrimental effect. Anxiety levels and exploratory behavior were not significantly different between all groups of mice. Hippocampal gene expression of MASH1, SYP and mTOR were reduced (P < 0.01 to P < 0.001) in T1DM mice, but significantly (P < 0.05 to P < 0.001) enhanced by twice daily (D-Ser2)Oxm[Lys38-γ-glu-PAL] intervention. Moreover, expression of SYP, mTOR and IRS-1 were significantly elevated (P < 0.05 to P < 0.001) in (D-Ser2)Oxm[Lys38-γ-glu-PAL] mice compared to both STZ and lean controls. These effects were accompanied by improved (P < 0.001) glucose tolerance and insulin sensitivity compared to STZ controls. Conclusion: The data highlight the potential of (D-Ser2)Oxm[Lys38-γ-glu-PAL] for the treatment of T1DM, and reveal the ability of this Oxm analogue to restore the deficits of learning and memory observed in STZ-induced T1DM.
目的:氧合调节素(Oxm)是一种胃肠道激素,近年来被认为具有治疗1型糖尿病(T1DM)的潜力。本研究研究了一种稳定的Oxm类似物对T1DM小鼠模型的焦虑、探索行为、认知功能、海马基因表达和代谢控制的影响。材料与方法:观察稳定的Oxm类似物(D-Ser2)Oxm[Lys38-γ-glu-PAL]每日两次给药对胰岛素缺乏型链脲佐菌素(STZ)诱导的T1DM小鼠的影响。结果:与正常对照组相比,STZ注射液诱导的糖尿病小鼠学习记忆功能明显受损(P < 0.05)。然而,(D-Ser2)Oxm[Lys38-γ- glul - pal]处理完全逆转了这种有害作用。各组小鼠的焦虑水平和探索行为无显著差异。T1DM小鼠海马MASH1、SYP、mTOR基因表达降低(P < 0.01 ~ P < 0.001),但每日2次(D-Ser2)Oxm[Lys38-γ- glul - pal]干预显著提高(P < 0.05 ~ P < 0.001)。此外,与STZ和瘦对照组相比,(D-Ser2)Oxm[Lys38-γ-glu-PAL]小鼠中SYP、mTOR和IRS-1的表达显著升高(P < 0.05 ~ P < 0.001)。与STZ对照组相比,这些效果伴随着葡萄糖耐量和胰岛素敏感性的改善(P < 0.001)。结论:这些数据突出了(D-Ser2)Oxm[Lys38-γ-glu-PAL]治疗T1DM的潜力,并揭示了这种Oxm类似物能够恢复stz诱导的T1DM的学习和记忆缺陷。
{"title":"(D-Ser2)Oxm[Lys38-γ-glu-PAL] improves hippocampal gene expression and cognition in a mouse model of type 1 diabetes -","authors":"N. Pathak, N. Irwin, V. Pathak, V. Gault, P. Flatt","doi":"10.5455/JEIM.050216.BR.027","DOIUrl":"https://doi.org/10.5455/JEIM.050216.BR.027","url":null,"abstract":"Objective: Oxyntomodulin (Oxm) is a gastrointestinal hormone with recently noted therapeutic potential for type 1 diabetes mellitus (T1DM). The present study examined the effects of a stable Oxm analogue on anxiety, exploratory behavior, cognitive function, hippocampal gene expression and metabolic control in a mouse model of T1DM. Materials and Methods: Effects of twice daily administration of the stable Oxm analogue, (D-Ser2)Oxm[Lys38-γ-glu-PAL], was assessed in insulin-deficient streptozotocin (STZ)-induced T1DM mice. Results: Induction of diabetes by STZ injection significantly (P < 0.05) impaired learning and memory compared to normal control mice. However, (D-Ser2)Oxm[Lys38-γ-glu-PAL] treatment completely reversed this detrimental effect. Anxiety levels and exploratory behavior were not significantly different between all groups of mice. Hippocampal gene expression of MASH1, SYP and mTOR were reduced (P < 0.01 to P < 0.001) in T1DM mice, but significantly (P < 0.05 to P < 0.001) enhanced by twice daily (D-Ser2)Oxm[Lys38-γ-glu-PAL] intervention. Moreover, expression of SYP, mTOR and IRS-1 were significantly elevated (P < 0.05 to P < 0.001) in (D-Ser2)Oxm[Lys38-γ-glu-PAL] mice compared to both STZ and lean controls. These effects were accompanied by improved (P < 0.001) glucose tolerance and insulin sensitivity compared to STZ controls. Conclusion: The data highlight the potential of (D-Ser2)Oxm[Lys38-γ-glu-PAL] for the treatment of T1DM, and reveal the ability of this Oxm analogue to restore the deficits of learning and memory observed in STZ-induced T1DM.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"27 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84630935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Review on Phyto-Pharmacological Potentials of Juniperus recurva - 刺柏植物药理潜力研究进展
Pub Date : 2016-01-01 DOI: 10.5455/JEIM.260416.RW.015
A. Rashid, Raja A. H. Kuchay
Juniperus recurva is a small tree or spreading shrub distributed from Afghanistan eastward through the Himalayas to southwest China. It is predominant in woodlands of the wetter areas of Himalayas (altitude of 1800 m to 3900 m), with moist and well-drained soils. It holds great potential as a medicinal plant. It has been traditionally used as anti-rheumatic, antiseptic, antispasmodic, antitoxic, aphrodisiac, astringent, carminative, rubificant and stomachic. However, very few authentic pharmacological studies on medicinal benefits of this plant have been conducted thus far. In a first of its kind, we review this plant for its chemical constituents, pharmacological activity and medicinal benefits. Keeping in view its success record as a traditional medicine to cure different ailments, it would be of interest to look for various bioactive natural products that might have therapeutic potential.
刺柏(Juniperus recurva)是一种小型乔木或蔓生灌木,分布于阿富汗,东经喜马拉雅山至中国西南部。它主要生长在喜马拉雅山湿润地区(海拔1800米至3900米)的林地,土壤湿润,排水良好。它作为一种药用植物具有很大的潜力。传统上被用作抗风湿、防腐、解痉、抗毒、催情、收敛、驱风、润湿和健胃。然而,迄今为止,对这种植物的药用价值进行的真正的药理学研究很少。本文首次对该植物的化学成分、药理活性和药用价值进行了综述。考虑到它作为一种治疗各种疾病的传统药物的成功记录,寻找可能具有治疗潜力的各种生物活性天然产品将是令人感兴趣的。
{"title":"A Review on Phyto-Pharmacological Potentials of Juniperus recurva -","authors":"A. Rashid, Raja A. H. Kuchay","doi":"10.5455/JEIM.260416.RW.015","DOIUrl":"https://doi.org/10.5455/JEIM.260416.RW.015","url":null,"abstract":"Juniperus recurva is a small tree or spreading shrub distributed from Afghanistan eastward through the Himalayas to southwest China. It is predominant in woodlands of the wetter areas of Himalayas (altitude of 1800 m to 3900 m), with moist and well-drained soils. It holds great potential as a medicinal plant. It has been traditionally used as anti-rheumatic, antiseptic, antispasmodic, antitoxic, aphrodisiac, astringent, carminative, rubificant and stomachic. However, very few authentic pharmacological studies on medicinal benefits of this plant have been conducted thus far. In a first of its kind, we review this plant for its chemical constituents, pharmacological activity and medicinal benefits. Keeping in view its success record as a traditional medicine to cure different ailments, it would be of interest to look for various bioactive natural products that might have therapeutic potential.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"61 1","pages":"93-97"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82111632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Nephroprotective activity of Homalium Letestui stem extract against paracetamol induced kidney injury 苦参茎提取物对扑热息痛所致肾损伤的保护作用
Pub Date : 2016-01-01 DOI: 10.5455/JEIM.250216.OR.147
J. Okokon, J. Simeon, E. Umoh
{"title":"Nephroprotective activity of Homalium Letestui stem extract against paracetamol induced kidney injury","authors":"J. Okokon, J. Simeon, E. Umoh","doi":"10.5455/JEIM.250216.OR.147","DOIUrl":"https://doi.org/10.5455/JEIM.250216.OR.147","url":null,"abstract":"","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"111 1","pages":"38-43"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76309330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Antioxidant Aerva lanata Extract Supresses Proliferation and Induce Mitochondria Mediated Apoptosis in Human Hepatocelluar carcinoma cell line 抗氧化水芹提取物抑制人肝癌细胞增殖并诱导线粒体介导的细胞凋亡
Pub Date : 2016-01-01 DOI: 10.5455/JEIM.270616.OR.153
N. Govindan
{"title":"Antioxidant Aerva lanata Extract Supresses Proliferation and Induce Mitochondria Mediated Apoptosis in Human Hepatocelluar carcinoma cell line","authors":"N. Govindan","doi":"10.5455/JEIM.270616.OR.153","DOIUrl":"https://doi.org/10.5455/JEIM.270616.OR.153","url":null,"abstract":"","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"16 1","pages":"71-81"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79789003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Membrane Lipid Peroxidation and Redox Status in Erythrocytes of Sickle Cell Anaemia Patients Incubated in Leaf Extract of Gongronema latifolium 镰状细胞性贫血患者红细胞膜脂过氧化和氧化还原状态的研究
Pub Date : 2016-01-01 DOI: 10.5455/JEIM.210616.OR.151
PAUL CHIDOKA CHIKEZIE
{"title":"Membrane Lipid Peroxidation and Redox Status in Erythrocytes of Sickle Cell Anaemia Patients Incubated in Leaf Extract of Gongronema latifolium","authors":"PAUL CHIDOKA CHIKEZIE","doi":"10.5455/JEIM.210616.OR.151","DOIUrl":"https://doi.org/10.5455/JEIM.210616.OR.151","url":null,"abstract":"","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"42 1","pages":"57-65"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88822849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Evaluation of lactogenic activity of Triumfetta rhomboidea L. root: Validating its traditional usage - 三叶草根的产乳活性评价:对其传统用途的验证
Pub Date : 2016-01-01 DOI: 10.5455/JEIM.160216.OR.146
H. Sahoo, P. Mandal, R. Sagar, S. Bhattamisra
ABSTRACT Objectives: The aim of the study was to investigate the lactogenic activity of aqueous extract of Triumfetta rhomboidea L. on nursing rats. Materials and methods: Rats (200-250 g) with suckling pups were selected and were divided into five groups (n=6). Group I treated as control; Group II treated as standard (Domperidone) and Group III, IV and V were orally administered with aqueous extract of T. rhomboidea roots (ATRR) at 125, 250 and 500 mg/kg body wt. respectively and continued for l4th day of parturition. Milk yield, the weight of pups and mother were measured daily. On 15th day, the total protein/carbohydrate contents (mammary tissue) and serum prolactin/cortisol level were measured and compared with control. Results: Oral administration of ATRR increases the milk yield, body weight of pups as well as mother rat, glycogen and protein content of mammary gland tissue, as well as serum prolactin and cortisol, level as compared to the control animals. In addition, the lactogenic effect of ATRR was followed dose dependent manner as compared to standard. Conclusion: The present study reveals that the ATRR possesses significant lactogenic activity by enhancing milk production and prolactin concentration in nursing rats.
【摘要】目的:研究三棱草水提物对哺乳大鼠的生乳活性。材料与方法:选取哺乳期大鼠(200 ~ 250 g),随机分为5组(n=6)。第一组为对照组;第二组为标准组(多潘立酮),第三组、第四组和第五组分别以125、250和500 mg/kg体重口服菱形根水提物(ATRR),持续至分娩第14天。每天测量产奶量、幼崽和母鼠体重。第15天,测定各组乳腺组织总蛋白/碳水化合物含量和血清泌乳素/皮质醇水平,并与对照组进行比较。结果:与对照组动物相比,口服ATRR可提高产奶量、幼崽和母鼠体重、乳腺组织糖原和蛋白质含量以及血清催乳素和皮质醇水平。此外,与标准对照,ATRR的产乳作用呈剂量依赖性。结论:ATRR通过提高哺乳大鼠的泌乳量和催乳素浓度,具有显著的产乳活性。
{"title":"Evaluation of lactogenic activity of Triumfetta rhomboidea L. root: Validating its traditional usage -","authors":"H. Sahoo, P. Mandal, R. Sagar, S. Bhattamisra","doi":"10.5455/JEIM.160216.OR.146","DOIUrl":"https://doi.org/10.5455/JEIM.160216.OR.146","url":null,"abstract":"ABSTRACT Objectives: The aim of the study was to investigate the lactogenic activity of aqueous extract of Triumfetta rhomboidea L. on nursing rats. Materials and methods: Rats (200-250 g) with suckling pups were selected and were divided into five groups (n=6). Group I treated as control; Group II treated as standard (Domperidone) and Group III, IV and V were orally administered with aqueous extract of T. rhomboidea roots (ATRR) at 125, 250 and 500 mg/kg body wt. respectively and continued for l4th day of parturition. Milk yield, the weight of pups and mother were measured daily. On 15th day, the total protein/carbohydrate contents (mammary tissue) and serum prolactin/cortisol level were measured and compared with control. Results: Oral administration of ATRR increases the milk yield, body weight of pups as well as mother rat, glycogen and protein content of mammary gland tissue, as well as serum prolactin and cortisol, level as compared to the control animals. In addition, the lactogenic effect of ATRR was followed dose dependent manner as compared to standard. Conclusion: The present study reveals that the ATRR possesses significant lactogenic activity by enhancing milk production and prolactin concentration in nursing rats.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"1 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90429280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
期刊
Journal of Experimental and Integrative Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1