Validation of an instrument to measure the quality of life in children with oropharyngeal mucositis undergoing cancer treatment

R. Gutiérrez-Vargas, Eduardo Velasco-Rojano, M. Villasís-Keever, J. Portilla-Robertson, Araceli Gutiérrez-Rodelo, Sonny Flores-Navarro, L. Juárez-Villegas, M. Zapata-Tarrés
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引用次数: 1

Abstract

Background Oropharyngeal mucositis (OM) is one of the primary complications arising during oncological treatment, which significantly reduces the patient's quality of life (QoL). The aim of this study was to translate, culturally adapt, and validate the use of a new Spanish version of the Oropharyngeal Mucositis-Specific Quality-of-Life instrument (OMQoL) for pediatric patients. Methods A multicentric, cross-sectional validation study was conducted to translate and adapt OMQoL from English to Spanish for its use by children with OM aged 8-16 years. Reliability was measured using Cronbach's alpha; content and construct validity, in conjunction with exploratory factor analysis. The convergent validity, with the correlations of the scales for OM defined by the WHO, OMAS (Oropharingeal Mucositis Assessment Scale) and the PedsQL-3 cancer module in Spanish. Results One hundred and ninety-three children with mean age of 10.91 ± 2.38 years participated in the study, out of which 101 (52.3%) were females. In this sample, 80 children (41.5%) suffered from acute lymphoblastic leukemia and 111 (57.5%) had grade 2 and 3 OM. The factorial analysis resulted in four dimensions with loads >0.40. Among the 31 items of the OMQoL, six were eliminated. Cronbach alpha of OMQoL-Spanish was 0.954. Spearman´s correlations (r) with the OMS and OMAS scales were significant (with r = -0.720 and r = -0.689; p < 0.01, respectively). Moderate correlation was observed with the PedsQL-3 cancer module (r = 0.426; p < 0.01). Conclusions OMQoL-Spanish demonstrated adequate psychometric properties, resulting in a reliable and valid instrument for measuring QoL in children with MO.
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一种测量接受癌症治疗的口咽黏膜炎儿童生活质量的仪器的验证
口咽粘膜炎(OM)是肿瘤治疗过程中出现的主要并发症之一,严重影响患者的生活质量。本研究的目的是翻译,文化适应,并验证新的西班牙语版本的口咽粘膜炎特异性生活质量仪器(OMQoL)对儿科患者的使用。方法采用多中心横断面验证研究,对8-16岁OM患儿的OMQoL进行英语翻译和西班牙语翻译。信度采用Cronbach’s alpha测量;内容和结构效度,结合探索性因子分析。WHO定义的OM量表、OMAS(口咽粘膜炎评估量表)和西班牙语PedsQL-3癌症模块的相关性的收敛效度。结果共入组儿童193例,平均年龄(10.91±2.38)岁,其中女性101例,占52.3%。在该样本中,80名儿童(41.5%)患有急性淋巴细胞白血病,111名(57.5%)患有2级和3级OM。因子分析结果显示,四个维度的负荷均>0.40。在OMQoL的31个项目中,有6个项目被取消。OMQoL-Spanish的Cronbach alpha为0.954。Spearman’s与OMS和OMAS量表的相关性(r)显著(r = -0.720和r = -0.689;P < 0.01)。与PedsQL-3癌模块有中度相关性(r = 0.426;P < 0.01)。结论omqol -西班牙语具有良好的心理测量特性,是一种可靠、有效的测量MO患儿生活质量的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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