Estimation of the number of RSV-associated hospitalisations in adults in the European Union

R. Osei-Yeboah, P. Spreeuwenberg, M. Del Riccio, T. Fischer, Amanda Marie Egeskov-Cavling, H. Bøås, M. van Boven, Xin Wang, Toni O Lehtonen, M. Bangert, H. Campbell, J. Paget
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引用次数: 4

Abstract

Background: Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in older adults that can result in hospitalisations and death. Estimating RSV-associated hospitalisation is critical for planning RSV-related healthcare needs for the ageing population across Europe. Methods: We gathered national RSV-associated hospitalisation estimates from the REspiratory Syncytial virus Consortium in EUrope (RESCEU) for adults in Denmark, England, Finland, Norway, Netherlands, and Scotland from 2006 to 2017. We extrapolated these estimates to 28 EU countries using nearest-neighbour matching, multiple imputations, and two sets of 10 indicators. Results: On average, 158 229 (95%CI: 140 865, 175 592) RSV-associated hospitalisations occur annually among adults in the EU (above 18 years); 92% of these hospitalisations occur in adults over 65 years. Among 75-84 years old, the annual average is estimated at 74 519 (95%CI: 69 923, 79 115) at a rate of 2.24 (95%CI: 2.10, 2.38) per 1000 adults. Among adults aged 85 years and above, the annual average is estimated at 37 904 (95%CI: 32 444, 43 363) at a rate of 2.99 (95%CI: 2.56, 3.42). Conclusion: Our estimates of RSV-associated hospitalisations in older adults are the first analysis integrating available data to provide estimates of the disease burden in this population across the EU. Importantly, for a condition which was considered in the past to be primarily a disease of young children, the average annual hospitalisation estimate in adults was lower but of a similar magnitude to the estimate in young children aged 0-4 years: 158 229 (95%CI: 140 865, 175 592) versus 245 244 (95%CI: 224 688, 265 799).
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欧盟成人rsv相关住院人数的估计
背景:呼吸道合胞病毒(RSV)是老年人下呼吸道感染的主要原因,可导致住院和死亡。估计与rsv相关的住院对于规划整个欧洲老龄化人口与rsv相关的医疗保健需求至关重要。方法:我们从欧洲呼吸道合胞病毒联盟(RESCEU)收集了2006年至2017年丹麦、英格兰、芬兰、挪威、荷兰和苏格兰成年人与rsv相关的全国住院估计数据。我们使用最近邻匹配、多重估算和两组10个指标,将这些估计外推到28个欧盟国家。结果:欧盟成年人(18岁以上)平均每年发生158229例(95%CI: 140 865, 175 592)与rsv相关的住院;92%的住院患者为65岁以上的成年人。在75-84岁的人群中,年平均估计为74 519例(95%CI: 69 923, 79 115),每1000名成年人中有2.24例(95%CI: 2.10, 2.38)。在85岁及以上的成年人中,年平均估计为37 904例(95%CI: 32 444, 43 363),发病率为2.99例(95%CI: 2.56, 3.42)。结论:我们对老年人rsv相关住院的估计是第一个整合现有数据的分析,提供了整个欧盟老年人疾病负担的估计。重要的是,对于过去被认为主要是幼儿疾病的疾病,成人的平均年住院估计较低,但与0-4岁幼儿的估计相似:158 229 (95%CI: 140 865, 175 592)对245 244 (95%CI: 224 688, 265 799)。
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