The role of Exenatide-GlP-1 receptor agonist- in the prevention and treatment of ovariectomy-induced osteoporosis in wistar rats: دور الأكسيناتيد-ناهض مستقبل الببتيد الشبيه بالغلوكاغون1- في العلاج والوقاية من هشاشة العظام المستحدثة باستئصال المبايض عند إناث جرذان ويستر

Journal of natural sciences, life and applied sciences Pub Date : 2022-03-27 DOI:10.26389/ajsrp.j070921

Loujain Ghassan Sallat, Marwan Abdo Khattab, Mahmoud Kasem Loujain Ghassan Sallat, Marwan Abdo Khattab, Mahmo

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Abstract

The present study aimed to investigate the protective and therapeutic effect of Exenatide on osteoporosis induced by ovariectomy in female Wister rats. The results of this study showed that administration of Exenatide at a dose of 10 mg/kg daily for 4 months led to a reduction in osteoporosis symptoms in ovariectomized rats, which was manifested by changes in serum levels of bone metabolism markers (a significant increase in the serum concentration of calcium, phosphorous, accompanied by a significant decrease in the potency of alkaline phosphatase), and a significant improvement in the tissue structure of the femur, in comparison with the members of the ovariectomized group. We conclude from this study the effectiveness of Exenatide in reducing the adverse effects of ovarian hormone deficiency on both bone structure and function in female Wister rats.

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在通过切除雌性大鼠的卵巢而诱发的骨质疏松症的治疗和预防方面，预防方面，俄罗斯联邦——在预防和控制类似青霉素的青霉素的未来方面发挥的作用作用——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————

本研究旨在探讨艾塞那肽对雌性Wister大鼠卵巢切除所致骨质疏松症的保护和治疗作用。本研究结果显示，以每日10mg /kg剂量给予艾塞那肽4个月后，去卵巢大鼠骨质疏松症症状减轻，表现为血清骨代谢标志物水平的改变(血清钙、磷浓度显著升高，同时碱性磷酸酶效力显著降低)，股骨组织结构明显改善。与去卵巢组相比。本研究结果表明艾塞那肽能有效降低卵巢激素缺乏对雌性Wister大鼠骨骼结构和功能的不良影响。

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Journal of natural sciences, life and applied sciences

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