{"title":"TGF-Beta and CTGF Mediated Signal Transduction Pathway and Fibrosis","authors":"J. Tian, Fang Yang, Huiqin Liu","doi":"10.1109/ICBEB.2012.397","DOIUrl":null,"url":null,"abstract":"Transforming growth factor-beta (TGF-β) is one of the important cell factors which cause the fibrous function, and connective tissue growth factor (CTGF) is considered to be the downstream factor of TGF-β, mediates fibrosis of TGF-β. TGF-β induces the expression of CTGF through multiple signal transduction pathways in promoting fibrosis. This article provides a brief summary of the research progress in this area.","PeriodicalId":6374,"journal":{"name":"2012 International Conference on Biomedical Engineering and Biotechnology","volume":"7 1","pages":"913-916"},"PeriodicalIF":0.0000,"publicationDate":"2012-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2012 International Conference on Biomedical Engineering and Biotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICBEB.2012.397","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Transforming growth factor-beta (TGF-β) is one of the important cell factors which cause the fibrous function, and connective tissue growth factor (CTGF) is considered to be the downstream factor of TGF-β, mediates fibrosis of TGF-β. TGF-β induces the expression of CTGF through multiple signal transduction pathways in promoting fibrosis. This article provides a brief summary of the research progress in this area.
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