Bis(pinacoloto)diboran/4-phenyl pyridine system for one-pot photocatalyzed borylation and reduction of aldehyde: synthesis of tavaborole in a flow reactor
Kankanala Naveen Kumar, Mouzma Mhate, Velayutham Ravichandiran, S. Swain
{"title":"Bis(pinacoloto)diboran/4-phenyl pyridine system for one-pot photocatalyzed borylation and reduction of aldehyde: synthesis of tavaborole in a flow reactor","authors":"Kankanala Naveen Kumar, Mouzma Mhate, Velayutham Ravichandiran, S. Swain","doi":"10.1055/a-2169-6200","DOIUrl":null,"url":null,"abstract":"A photocatalyzed one-pot borylation of haloarene and reduction of aldehyde by cocatalysis of bis(pinacoloto)diboran/4-phenyl pyridine is reported. The reaction was carried out in a flow reactor by irradiating the reaction at 410nm, with residence time of 10 min. The method was successfully applied for the synthesis of tavaborole in a single step with 81% yield.","PeriodicalId":49451,"journal":{"name":"Synthesis-Stuttgart","volume":"2 1","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthesis-Stuttgart","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1055/a-2169-6200","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A photocatalyzed one-pot borylation of haloarene and reduction of aldehyde by cocatalysis of bis(pinacoloto)diboran/4-phenyl pyridine is reported. The reaction was carried out in a flow reactor by irradiating the reaction at 410nm, with residence time of 10 min. The method was successfully applied for the synthesis of tavaborole in a single step with 81% yield.
期刊介绍：
SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
