Median Lethal Dose (Ld50) Of Electric Current

S. Saganuwan
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Abstract

Electrical related deaths are more frequent among school age children as a result of high voltage and lightning strike [1]. Lightening, a transfer of an electrical charge, which results in discharge of static electricity, kills about 1000 people in the US every year [2]. Lightening causes muscular spasm, neurosis, thrombosis, damage of blood vessels, unconsciousness, cardiac arrest, hypoxia, respiratory arrest and death [3]. The types of lightning strikes are intracloud, cloud to ground and ground to cloud [4]. The most important resistor to the flow of current from lightening electricity is skin [5]. Estimated are 50,000 thunderstorms, 8 million lightning flashes [6], with mortality rate of 30% [7] and survival rate of 70% [8], affecting more people of less than 40years of age [9]. The effect depends on the intensity of current, voltage, body exposure among others [10]. A voltage of 30V can cause ventricular fibrillation. Electric shock is a sudden violent response to electric current, which may lead to death (electrocution). Let go phenomenon for high voltage (7600V) could be tolerated for 100 milliseconds or less [11]. Lightning has been considered by some ethnic groups as myth, miracle and mirage [12], which is cruelty to animals, and may be caused by witches [13]. In view of traditional beliefs and toxicity effects associated with lightning and electric current, there is need for acute toxicity study of electric current, with a view to determining the resistance threshold of lightning and electric current in humans and animals.
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电流中位致死剂量(Ld50)
由于高压和雷击,电气相关死亡在学龄儿童中更为常见[1]。闪电是一种电荷转移导致静电放电的现象,在美国每年约有1000人死于闪电[2]。闪电会导致肌肉痉挛、神经衰弱、血栓形成、血管损伤、意识丧失、心脏骤停、缺氧、呼吸停止和死亡[3]。雷击的类型有云内雷击、云对地雷击和地对云雷击[4]。对雷电电流流动最重要的电阻是皮肤[5]。估计每年有5万次雷暴,800万次闪电[6],死亡率为30%[7],存活率为70%[8],影响人群多为40岁以下[9]。这种效应取决于电流、电压、人体暴露等因素的强度[10]。30V的电压可引起心室颤动。触电是对电流的突然剧烈反应,可能导致死亡(触电)。高压(7600V)下的放空现象可容忍100毫秒或更短[11]。闪电被一些民族认为是神话、奇迹和海市蜃楼[12],对动物是残忍的,可能是女巫造成的[13]。鉴于传统观念和雷电与电流的毒性作用,有必要对电流进行急性毒性研究,以确定人类和动物对雷电和电流的电阻阈值。
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