Pub Date : 2021-07-29DOI: 10.19080/ctbeb.2019.19.556015
T. Ugorji
Objective: to find out the effect of managerial protocols, age and gender on the prevalence of specific gait patterns among children suffering from cerebral palsy. It is expected that this study will help researchers and clinicians focus their efforts in areas that will enhance the general functioning and the gait efficiency of children suffering from cerebral palsy instead of incorporating excessive treatment options that might have little or no effect on the gait improvement of patients with cerebral palsy.
{"title":"The Effect of Gender, Age and Cerebral Palsy Sub-Type on The Prevalence of Specific Gait Deviations in Cerebral Palsy Children","authors":"T. Ugorji","doi":"10.19080/ctbeb.2019.19.556015","DOIUrl":"https://doi.org/10.19080/ctbeb.2019.19.556015","url":null,"abstract":"Objective: to find out the effect of managerial protocols, age and gender on the prevalence of specific gait patterns among children suffering from cerebral palsy. It is expected that this study will help researchers and clinicians focus their efforts in areas that will enhance the general functioning and the gait efficiency of children suffering from cerebral palsy instead of incorporating excessive treatment options that might have little or no effect on the gait improvement of patients with cerebral palsy.","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89340153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-29DOI: 10.19080/CTBEB.2021.20.556028
A. Hill, Antonio Alexandre Speri Alves, R. Barreto, F. Bressan, M. Miglino, J. M. Garcia
Introduction: Female infertility is a condition that is currently treated through the maximization of existing reserves; a necessity due to the fact that a true reversal of the processes leading to infertility is not yet technologically possible. This experiment examined the ability of mesenchymal stem cells to differentiate into primordial germ cells (PGC) when cultured onto the placental scaffold. Methods: To produce the scaffolds, the cotelydons were collected and decellularized by umbilical vessel SDS perfusion. Adipose derived cells were isolated based on rapid adherence to the plastic. Results: The isolated cells displayed the markers CD90 and 105, while lacked CD34 and CD45. When seeded onto the scaffold, the cells successfully differentiated into PGC like cells, displaying typical PGCs markers, including STELLA, OCT4, DAZL and VASA. Discussion: These materials were chosen for their low cost and wide availability. The data in this study show the promising potential of cell-scaffold complex to support the development of female tissue engineering-based regenerative medicine therapies.
{"title":"Female Bioengineering: Primordial Germ Cell Differentiation of Mesenchymal Stem Cells onto Placental Scaffolds","authors":"A. Hill, Antonio Alexandre Speri Alves, R. Barreto, F. Bressan, M. Miglino, J. M. Garcia","doi":"10.19080/CTBEB.2021.20.556028","DOIUrl":"https://doi.org/10.19080/CTBEB.2021.20.556028","url":null,"abstract":"Introduction: Female infertility is a condition that is currently treated through the maximization of existing reserves; a necessity due to the fact that a true reversal of the processes leading to infertility is not yet technologically possible. This experiment examined the ability of mesenchymal stem cells to differentiate into primordial germ cells (PGC) when cultured onto the placental scaffold. Methods: To produce the scaffolds, the cotelydons were collected and decellularized by umbilical vessel SDS perfusion. Adipose derived cells were isolated based on rapid adherence to the plastic. Results: The isolated cells displayed the markers CD90 and 105, while lacked CD34 and CD45. When seeded onto the scaffold, the cells successfully differentiated into PGC like cells, displaying typical PGCs markers, including STELLA, OCT4, DAZL and VASA. Discussion: These materials were chosen for their low cost and wide availability. The data in this study show the promising potential of cell-scaffold complex to support the development of female tissue engineering-based regenerative medicine therapies.","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76854382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-07DOI: 10.19080/ctbeb.2019.18.555982
A. Belousov
{"title":"Physical Method of Stabilization of Membranes of Preserved RBCs by Means of Nanotechnology","authors":"A. Belousov","doi":"10.19080/ctbeb.2019.18.555982","DOIUrl":"https://doi.org/10.19080/ctbeb.2019.18.555982","url":null,"abstract":"","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74873288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-27DOI: 10.19080/CTBEB.2021.20.556027
Alicia García Falgueras
Polymerase Chain Reaction (PCR) is a molecular technique more suitable for accurate diagnoses because of its specificity in targeting and identifying specific pathogens. PCR technique is reliable to detect the genetic presence of the virus in the host since the very beginning of the infection, no matter how the immune system of the person might react. Moreover, the samples for the test contains the DNA information during quite a long time since the extraction. Programmable thermal operation cycler for controlling heating and cooling is the procedure to denaturation into two single strands, annealing and extension reactions of the DNA. The PCR is certainly having a clinical approach, because do not emphasized on how the immune system of the patient might reacts to the infection, only on whether the specific virus is present or not for the accurate diagnoses and subsequently proceed with an appropriated medical treatment to restore health.
{"title":"Polymerase Chain Reaction (PCR) and How Temperature Modifies Nucleotide Pairings","authors":"Alicia García Falgueras","doi":"10.19080/CTBEB.2021.20.556027","DOIUrl":"https://doi.org/10.19080/CTBEB.2021.20.556027","url":null,"abstract":"Polymerase Chain Reaction (PCR) is a molecular technique more suitable for accurate diagnoses because of its specificity in targeting and identifying specific pathogens. PCR technique is reliable to detect the genetic presence of the virus in the host since the very beginning of the infection, no matter how the immune system of the person might react. Moreover, the samples for the test contains the DNA information during quite a long time since the extraction. Programmable thermal operation cycler for controlling heating and cooling is the procedure to denaturation into two single strands, annealing and extension reactions of the DNA. The PCR is certainly having a clinical approach, because do not emphasized on how the immune system of the patient might reacts to the infection, only on whether the specific virus is present or not for the accurate diagnoses and subsequently proceed with an appropriated medical treatment to restore health.","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"211 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74967818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.19080/ctbeb.2021.20.556026
S. Jana
{"title":"Influence of Consciousness Energy Healing Treatment on the Isotopic Abundance Ratio of Sulfamethoxazole Using LC-MS and GC-MS Spectrometry","authors":"S. Jana","doi":"10.19080/ctbeb.2021.20.556026","DOIUrl":"https://doi.org/10.19080/ctbeb.2021.20.556026","url":null,"abstract":"","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76896327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-28DOI: 10.19080/ctbeb.2020.19.556025
A. Rima
{"title":"Toward a Noninvasive Measurement Method of CO2 Arterial Pressure","authors":"A. Rima","doi":"10.19080/ctbeb.2020.19.556025","DOIUrl":"https://doi.org/10.19080/ctbeb.2020.19.556025","url":null,"abstract":"","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86467294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-29DOI: 10.19080/ctbeb.2020.19.556024
S. Badalyan, S. Rapior
Macrofungi (mushrooms) have widely been appreciated all over the world for their nutritional values and medicinal properties. They have been used in traditional medicine for more than 3000 years for prevention and treatment of different diseases. Modern scientific research shows that macrofungi are producers of a broad spectrum of high- and low-molecular-weight bioactive compounds, i.e., alkaloids, polysaccharides, proteins, phenolics, terpenoids, polyketides, cyclic peptides, lectins and ribosome-inactivating proteins. They have various therapeutic effects as antidiabetic, anti-inflammatory, antimicrobial, antioxidant, antitumor, antiviral, cardioprotective, hepatoprotective, hypocholesterolemic, hypotensive, immunomodulatory, neuroprotective and regenerative, and possess promising pharmacological potential. Development of fungal biotechnological cultivation industry will support production of macrofungi-derived biotech products, healthy food and mycopharmaceuticals pharmaceuticals. Further advances in fungal biology and biotechnology, genomics and proteomics will assist biomedical research and application of macrofungi.
{"title":"Perspectives of Biomedical Application of Macrofungi","authors":"S. Badalyan, S. Rapior","doi":"10.19080/ctbeb.2020.19.556024","DOIUrl":"https://doi.org/10.19080/ctbeb.2020.19.556024","url":null,"abstract":"Macrofungi (mushrooms) have widely been appreciated all over the world for their nutritional values and medicinal properties. They have \u0000been used in traditional medicine for more than 3000 years for prevention and treatment of different diseases. Modern scientific research shows \u0000that macrofungi are producers of a broad spectrum of high- and low-molecular-weight bioactive compounds, i.e., alkaloids, polysaccharides, \u0000proteins, phenolics, terpenoids, polyketides, cyclic peptides, lectins and ribosome-inactivating proteins. They have various therapeutic effects \u0000as antidiabetic, anti-inflammatory, antimicrobial, antioxidant, antitumor, antiviral, cardioprotective, hepatoprotective, hypocholesterolemic, \u0000hypotensive, immunomodulatory, neuroprotective and regenerative, and possess promising pharmacological potential. Development of fungal \u0000biotechnological cultivation industry will support production of macrofungi-derived biotech products, healthy food and mycopharmaceuticals \u0000pharmaceuticals. Further advances in fungal biology and biotechnology, genomics and proteomics will assist biomedical research and application \u0000of macrofungi.","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84530641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-08DOI: 10.19080/ctbeb.2020.19.556022
F. Pittella, Gualberto Acm Valle Abcs, Gualberto Acm
After twenty years of short interfering RNA (siRNA) research, RNA interference (RNAi)-based medicines are emerging as a novel class of drugs since the recent approval of Onpattro® and Givlaari® by the Food and Drug Administration (FDA). RNAi is a post-transcriptional gene regulatory process in which one of its molecular effectors is a silencing inducer: the siRNA. Since the description of this pathway, several research groups are searching for therapeutic applications of siRNA against diseases with overexpressed genes. Many challenges came across and strategies to improve siRNA stability and delivery were developed. Nevertheless, higher efficacy, safety and successful delivery are still some of the challenges to be overcome. In this mini review, we are presenting some of the biological barriers for effective siRNA delivery as well as an update of the current progress in RNAi-based medicines in phase III clinical trials.
{"title":"Short Interfering RNA (siRNA) based Medicines and the Future of RNAi Therapy: A Mini Review","authors":"F. Pittella, Gualberto Acm Valle Abcs, Gualberto Acm","doi":"10.19080/ctbeb.2020.19.556022","DOIUrl":"https://doi.org/10.19080/ctbeb.2020.19.556022","url":null,"abstract":"After twenty years of short interfering RNA (siRNA) research, RNA interference (RNAi)-based medicines are emerging as a novel class of drugs since the recent approval of Onpattro® and Givlaari® by the Food and Drug Administration (FDA). RNAi is a post-transcriptional gene regulatory process in which one of its molecular effectors is a silencing inducer: the siRNA. Since the description of this pathway, several research groups are searching for therapeutic applications of siRNA against diseases with overexpressed genes. Many challenges came across and strategies to improve siRNA stability and delivery were developed. Nevertheless, higher efficacy, safety and successful delivery are still some of the challenges to be overcome. In this mini review, we are presenting some of the biological barriers for effective siRNA delivery as well as an update of the current progress in RNAi-based medicines in phase III clinical trials.","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91075681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-28DOI: 10.19080/ctbeb.2019.19.556021
A. Koolmees
Patients with dementia often suffer from behavioral changes. A common behavioral change is acute physical aggressive behavior which is the most distressing change. This can lead to harm, which is especially problematic in nursing homes. Despite the serious safety concerns, antipsychotics are often prescribed to combat this problem. This article is aimed to review the evidence of the efficacy of utilizing antipsychotics in acutely treating physical aggressive behavior in patients with dementia in nursing homes. Therefore, a systematic literature search was performed. The results included a meta-analysis confirmed statistically significant reduction in physical aggression when risperidone was compared to placebo. On the other hand, a randomized controlled trial showed no change in physical aggressive behavior between quetiapine and placebo. More research is needed to fully investigate the benefits on physical aggressive behavior and safety concerns of all the antipsychotics in patients with dementia in nursing homes. .
{"title":"The Efficacy of Antipsychotics in the treatment of Physical Aggressive behavior in Patients with Dementia in Nursing Homes","authors":"A. Koolmees","doi":"10.19080/ctbeb.2019.19.556021","DOIUrl":"https://doi.org/10.19080/ctbeb.2019.19.556021","url":null,"abstract":"Patients with dementia often suffer from behavioral changes. A common behavioral change is acute physical aggressive behavior which is the most distressing change. This can lead to harm, which is especially problematic in nursing homes. Despite the serious safety concerns, antipsychotics are often prescribed to combat this problem. This article is aimed to review the evidence of the efficacy of utilizing antipsychotics in acutely treating physical aggressive behavior in patients with dementia in nursing homes. Therefore, a systematic literature search was performed. The results included a meta-analysis confirmed statistically significant reduction in physical aggression when risperidone was compared to placebo. On the other hand, a randomized controlled trial showed no change in physical aggressive behavior between quetiapine and placebo. More research is needed to fully investigate the benefits on physical aggressive behavior and safety concerns of all the antipsychotics in patients with dementia in nursing homes. .","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86611882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-27DOI: 10.19080/ctbeb.2019.19.556020
Liang-deng Zhang
Optical tweezers is a tool based on strongly focused laser beam trapping force. The of a laser beam originates from the gradient of electric field containing in the focused laser beam. Laser tweezers has been used increasingly as a unique technique for optical trapping, manipulation, and characterizations of biological cells and dielectric micro- and nano-scale particles. It can also be used to make quantitative measurements of living cells.
{"title":"Optical Tweezers and Their Applications in Biomedical Engineering","authors":"Liang-deng Zhang","doi":"10.19080/ctbeb.2019.19.556020","DOIUrl":"https://doi.org/10.19080/ctbeb.2019.19.556020","url":null,"abstract":"Optical tweezers is a tool based on strongly focused laser beam trapping force. The of a laser beam originates from the gradient of electric field containing in the focused laser beam. Laser tweezers has been used increasingly as a unique technique for optical trapping, manipulation, and characterizations of biological cells and dielectric micro- and nano-scale particles. It can also be used to make quantitative measurements of living cells.","PeriodicalId":11007,"journal":{"name":"Current Trends in Biomedical Engineering & Biosciences","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90268689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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