N- and / or O- Alkylation of Quinazolinone Derivatives

Abstract

Here we report on a strategy based on the capabilities of 2D NMR spectroscopy, which focuses on determining the exact structures of promising HDAC / VEGF-2 inhibitors and intermediate N- or O-alkylated building blocks for their construction. Due to which, in contrast to the erroneous conclusions of other studies, it has been unequivocally established that quinazolin-4-ones with alkyl halides under the classical conditions of two-phase catalysis: the solid phase (alkali metal carbonates) and liquid (aprotic solvents) are subjected to alkylation in the 3-N-position.