Evaluation of Analgesic and Antipyretic Activity of Tridax Procumbens Leaves Extract

Abstract

A B S T R A C T This study was designed to evaluate the analgesic and antipyretic activity of leaves extract of Tridax procumbens Linn. (ethanolic and ethyl acetate). Analgesic activity was investigated against Acetic acid and sodium chloride induced Writhing test in rats. TPEE at 300mg/kg (P.O.) shows better analgesic activity than TPEAE while both extracts at 200mg/kg (P.O.) have very low analgesic activity. Ethanolic and Ethyl acetate extracts of Tridax procumbens were evaluated for antipyretic activity using hyperpyrexia induced in rabbits by Typhoid-Paratyphoid A, B vaccine. Like Paracetamol 100 mg/kg (I.V.) Tridax procumbens showed significant reduction in elevated body temperature at 300 mg/kg (P.O.) .The analgesic and antipyretic activity of Tridax procumbens leaves could be at least in part due to the presence of flavonoids and other polyphenols in the extracts.